Decreased IL-10 expression in stefin B-deficient macrophages is regulated by the MAP kinase and STAT-3 signaling pathways

FEBS Letters

Volumn 588, Issue 5, 2014, Pages 720-726

  Maher, Katarina ^a   Završnik, Janja ^a   Jerič Kokelj, Barbara ^a   Vasiljeva, Olga ^a   Turk, Boris ^a,b,c   Kopitar Jerala, Nataša ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins (CIPKeBiP)   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Cystatin; Interleukin 10; Lipopolysaccharide; Macrophage; MAP kinase; Nitric oxide

Indexed keywords

CYSTATIN B; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

CYSTATIN; INTERLEUKIN-10; LIPOPOLYSACCHARIDE; MACROPHAGE; MAP-KINASE; NITRIC OXIDE;

ANIMALS; CELLS, CULTURED; CYSTATIN B; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERFERON-GAMMA; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE, KNOCKOUT; NITRIC OXIDE; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 84896703954     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.01.015     Document Type: Article

References (38)

1. V. Turk, V. Stoka, and D. Turk Cystatins: biochemical and structural properties, and medical relevance Front. Biosci. 13 2008 5406 5420
2. N. Kopitar-Jerala The role of cystatins in cells of the immune system FEBS Lett. 580 2006 6295 6301
3. S. Ceru et al. Stefin B interacts with histones and cathepsin L in the nucleus J. Biol. Chem. 285 2010 10078 10086
4. M.D. Lalioti, H.S. Scott, C. Buresi, C. Rossier, A. Bottani, M.A. Morris, A. Malafosse, and S.E. Antonarakis Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy Nature 386 1997 847 851
5. L.A. Pennacchio et al. Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) Science 271 1996 1731 1734
6. L.A. Pennacchio, D.M. Bouley, K.M. Higgins, M.P. Scott, J.L. Noebels, and R.M. Myers Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice Nat. Genet. 20 1998 251 258
7. M.K. Lehtinen et al. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1 J. Neurosci. 29 2009 5910 5915
8. N. Kopitar-Jerala, A. Schweiger, R.M. Myers, V. Turk, and B. Turk Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins FEBS Lett. 579 2005 2149 2155
9. L. Verdot, G. Lalmanach, V. Vercruysse, J. Hoebeke, F. Gauthier, and B. Vray Chicken cystatin stimulates nitric oxide release from interferon-γ- activated mouse peritoneal macrophages via cytokine synthesis Eur. J. Biochem. 266 1999 1111 1117
10. S. Hartmann, A. Schönemeyer, B. Sonnenburg, B. Vray, and R. Lucius Cystatins of filarial nematodes up-regulate the nitric oxide production of interferon-γ-activated murine macrophages Parasite Immunol. 24 2002 253 262
11. D.F. Fiorentino, A. Zlotnik, T.R. Mosmann, M. Howard, and A. O'Garra IL-10 inhibits cytokine production by activated macrophages J. Immunol. 147 1991 3815 3822
12. R. Kühn, J. Löhler, D. Rennick, K. Rajewsky, and W. Müller Interleukin-10-deficient mice develop chronic enterocolitis Cell 75 1993 263 274
13. E.-O. Glocker et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor N. Engl. J. Med. 361 2009 2033 2045
14. L. Siewe, M. Bollati-Fogolin, C. Wickenhauser, T. Krieg, W. Müller, and A. Roers Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA Eur. J. Immunol. 36 2006 3248 3255
15. R. de Waal Malefyt, J. Abrams, B. Bennett, C.G. Figdor, and J.E. de Vries Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes J. Exp. Med. 174 1991 1209 1220
16. M. Saraiva, and A. O'Garra The regulation of IL-10 production by immune cells Nat. Rev. Immunol. 10 2010 170 181
17. M. Lucas, X. Zhang, V. Prasanna, and D.M. Mosser ERK activation following macrophage Fc[gamma]R ligation leads to chromatin modifications at the IL-10 locus J. Immunol. 175 2005 469 477
18. X. Zhang, J.P. Edwards, and D.M. Mosser Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription J. Immunol. 177 2006 1282 1288
19. W. Ma The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages J. Biol. Chem. 276 2001 13664 13674
20. N. Kopitar-Jerala, T. Bevec, D. Barlic-Maganja, F. Gubensek, and V. Turk Anti-cathepsin L monoclonal antibodies that distinguish cathepsin L from cathepsin V Biol. Chem. 382 2001 867 870
21. Weischenfeldt, J. and Porse, B. (2008). Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protoc.1.
22. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138
23. S.I. Hashimoto, T. Suzuki, H.Y. Dong, N. Yamazaki, and K. Matsushima Serial analysis of gene expression in human monocytes and macrophages Blood 94 1999 837 844
24. R. Rinne, P. Saukko, M. Jarvinen, and A.E. Lehesjoki Reduced cystatin B activity correlates with enhanced cathepsin activity in progressive myoclonus epilepsy Ann. Med. 34 2002 380 385
25. R. Di Giaimo, M. Riccio, S. Santi, C. Galeotti, D.C. Ambrosetti, and M. Melli New insights into the molecular basis of progressive myoclonus epilepsy: a multiprotein complex with cystatin B Hum. Mol. Genet. 11 2002 2941 2950
26. D.J. Stuehr, and M.A. Marletta Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma J. Immunol. 139 1987 518 525
27. C. Klotz et al. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages PLoS Pathog. 7 2011 1001248
28. K.H. Frendeus, H. Wallin, S. Janciauskiene, and M. Abrahamson Macrophage responses to interferon-gamma are dependent on cystatin C levels Int. J. Biochem. Cell Biol. 41 2009 2262 2269
29. M. Tone, M.J. Powell, Y. Tone, S.A. Thompson, and H. Waldmann IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3 J. Immunol. 165 2000 286 291
30. H.D. Brightbill, S.E. Plevy, R.L. Modlin, and S.T. Smale A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages J. Immunol. 164 2000 1940 1951
31. H. Chanteux, A.C. Guisset, C. Pilette, and Y. Sibille LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms Respir. Res. 8 2007 71
32. T. Suzuki et al. Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE Blood 96 2000 2584 2591
33. C. Schnoeller et al. A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages J. Immunol. 180 2008 4265 4272
34. C. Luciano-Montalvo, and L.M. Melendez Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages Placenta 30 2009 464 467
35. L. Rivera-Rivera, J. Perez-Laspiur, K. Colon, and L.M. Melendez Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs J. Neurovirol. 18 2012 20 29
36. K. Lieuallen, L.A. Pennacchio, M. Park, R.M. Myers, and G.G. Lennon Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes Hum. Mol. Genet. 10 2001 1867 1871
37. C. Zocchia, G. Spiga, S.J. Rabin, M. Grekova, J. Richert, O. Chernyshev, C. Colton, and I. Mocchetti Biological activity of interleukin-10 in the central nervous system Neurochem. Int. 30 1997 433 439
38. A. Bachis, A.M. Colangelo, S. Vicini, P.P. Doe, M.A. De Bernardi, G. Brooker, and I. Mocchetti Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity J. Neurosci. 21 2001 3104 3112