Iron deficiency in patients with idiopathic pulmonary arterial hypertension

Heart Lung and Circulation

Volumn 23, Issue 3, 2014, Pages 287-292

  Van Empel, Vanessa P M ^a,b   Lee, Joy ^b   Williams, Trevor J ^b   Kaye, David M ^a,b,c  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Anaemia; Exercise capacity; Haemodynamics; Iron deficiency; Pulmonary arterial hypertension

Indexed keywords

ADULT; ANEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXERCISE TOLERANCE; FEMALE; FUNCTIONAL STATUS; HEART INDEX; HEART RIGHT VENTRICLE FUNCTION; HUMAN; IRON DEFICIENCY; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; NEW YORK HEART ASSOCIATION CLASS; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

ANAEMIA; EXERCISE CAPACITY; HAEMODYNAMICS; IRON DEFICIENCY; PULMONARY ARTERIAL HYPERTENSION;

ADULT; AGED; FEMALE; HUMANS; HYPERTENSION, PULMONARY; IRON; MALE; MIDDLE AGED; PULMONARY ARTERY;

EID: 84896703814     PISSN: 14439506     EISSN: 14442892     Source Type: Journal    
DOI: 10.1016/j.hlc.2013.08.007     Document Type: Article

References (14)

1. Galie N., Hoeper M.M., Humbert M., Torbicki A., Vachiery J.L., Barbera J.A., et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 2009, 30:2493-2537.
2. Rhodes C.J., Howard L.S., Busbridge M., Ashby D., Kondili E., Gibbs J.S., et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights. J Am Coll Cardiol 2011, 58:300-309.
3. Ruiter G., Lankhorst S., Boonstra A., Postmus P.E., Zweegman S., Westerhof N., et al. Iron deficiency is common in idiopathic pulmonary arterial hypertension. Eur Respir J 2011, 37:1386-1391.
4. Smith T.G., Talbot N.P., Privat C., Rivera-Ch M., Nickol A.H., Ratcliffe P.J., et al. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA 2009, 302:1444-1450.
5. Maeder M.T., Khammy O., dos Remedios C., Kaye D.M. Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. J Am Coll Cardiol 2011, 58:474-480.
6. Gonzalez-Costello J., Comin-Colet J. Iron deficiency and anaemia in heart failure: understanding the FAIR-HF trial. Eur J Heart Fail 2010, 12:1159-1162.
7. Maurer M.S., Teruya S., Chakraborty B., Helmke S., Mancini D. Treating Anemia in Older Adults with Heart Failure with a Preserved Ejection Fraction (HFPEF) with epoetin alfa: single blind randomized clinical trial of safety and efficacy. Circ Heart Fail 2013, 6:254-263.
8. Thomas C., Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem 2002, 48:1066-1076.
9. Lang R.M., Bierig M., Devereux R.B., Flachskampf F.A., Foster E., Pellikka P.A., et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005, 18:1440-1463.
10. Nagueh S.F., Appleton C.P., Gillebert T.C., Marino P.N., Oh J.K., Smiseth O.A., et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 2009, 10:165-193.
11. Rhodes C.J., Wharton J., Howard L., Gibbs J.S., Vonk-Noordegraaf A., Wilkins M.R. Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target. Eur Respir J 2011, 38:1453-1460.
12. Cook J.D., Dassenko S., Skikne B.S. Serum transferrin receptor as an index of iron absorption. Br J Haematol 1990, 75:603-609.
13. Westenbrink B.D., Visser F.W., Voors A.A., Smilde T.D., Lipsic E., Navis G., et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well. Eur Heart J 2007, 28:166-171.
14. Anker S.vH.S. Anaemia in chronic heart failure 2009, International Medical Publishers, Bremen.