Can computed tomography help us identify asthmatic phenotypes?

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 3, 2014, Pages 739-740

  Sheshadri, Ajay ^a   Hoffman, Eric A ^b   Castro, Mario ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

asthma; biomarker; Endotype; phenotype

Indexed keywords

BIOLOGICAL MARKER;

AIRWAY REMODELING; ASTHMA; COMPUTER ASSISTED TOMOGRAPHY; EDITORIAL; FUNCTIONAL RESIDUAL CAPACITY; HEALTH CARE COST; HUMAN; IMAGE ANALYSIS; LUNG FUNCTION; PHENOTYPE; PRIORITY JOURNAL; TOTAL LUNG CAPACITY;

ASTHMA; BIOMARKER; ENDOTYPE; PHENOTYPE;

AIRWAY REMODELING; ASTHMA; FEMALE; HUMANS; MALE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84896703405     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.12.1036     Document Type: Editorial

References (14)

1. S.B. Barnett, and T.A. Nurmagambetov Costs of asthma in the United States: 2002-2007 J Allergy Clin Immunol 127 2011 145 152
2. G.P. Anderson Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease Lancet 372 2008 1107 1119
3. W.C. Moore, D.A. Meyers, S.E. Wenzel, W.G. Teague, H. Li, and X. Li et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program Am J Respir Crit Care Med 181 2010 315 323
4. P. Haldar, I.D. Pavord, D.E. Shaw, M.A. Berry, M. Thomas, and C.E. Brightling et al. Cluster analysis and clinical asthma phenotypes Am J Respir Crit Care Med 178 2008 218 224
5. A.M. Fitzpatrick, W.G. Teague, D.A. Meyers, S.P. Peters, X. Li, and H. Li et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute's Severe Asthma Research Program J Allergy Clin Immunol 127 2011 382 389 e1-13
6. M. Castro, S. Fain, E. Hoffman, D. Gierada, S. Erzurum, and S. Wenzel et al. Lung imaging in asthmatic patients: the picture is clearer J Allergy Clin Immunol 107 2011 65 70
7. R.S. Aysola, E.A. Hoffman, D. Gierada, S. Wenzel, J. Cook-Granroth, and J. Tarsi et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology Chest 134 2008 1183 1191
8. A. Niimi, H. Matsumoto, R. Amitani, Y. Nakano, M. Mishima, and M. Minakuchi et al. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices Am J Respir Crit Care Med 162 2000 1518 1523
9. K. Kasahara, K. Shiba, T. Ozawa, K. Okuda, and M. Adachi Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma Thorax 57 2002 242 246
10. A. Busacker, J.D. Newell Jr., T. Keefe, E.A. Hoffman, J.C. Granroth, and M. Castro et al. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis Chest 135 2009 48 56
11. S.W. Park, J.S. Park, S.H. Jeong, Y.N. Lee, Y. Hwangbo, and J.S. Park et al. Air trapping is a major determinant of persistent airway obstruction in asthmatics Respir Med 106 2012 786 793
12. S.R. Boser, H. Park, S.F. Perry, M.G. Menache, and F.H. Green Fractal geometry of airway remodeling in human asthma Am J Respir Crit Care Med 172 2005 817 823
13. S. Gupta, R. Hartley, U.T. Khan, A. Singapuri, B. Hargadon, and W. Monteiro et al. Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients J Allergy Clin Immunol 133 2014 729 738
14. P. Grenier, I. Mourey-Gerosa, K. Benali, M.W. Brauner, A.N. Leung, and S. Lenoir et al. Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability Eur Radiol 6 1996 199 206