Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction

Journal of Physiology

Volumn 592, Issue 5, 2014, Pages 1061-1075

  Umbrello, Michele ^a,b   Dyson, Alex ^a   Pinto, Bernardo Bollen ^a   Fernandez, Bernadette O ^c   Simon, Verena ^a,d   Feelisch, Martin ^c   Singer, Mervyn ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; HEMOGLOBIN; MITOCHONDRIAL ENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; OXYGEN; SODIUM NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD LEVEL; BREATHING PATTERN; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME SYNTHESIS; ERYTHROCYTE; HEART OUTPUT; HYPOXEMIA; HYPOXIA; IN VIVO STUDY; MALE; METABOLITE; NITRITE BLOOD LEVEL; NITROSATION; NITROSYLATION; NONHUMAN; OXIDATION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SYSTEMIC DISEASE; VASODILATATION; WISTAR RAT;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; AORTA; BLOOD FLOW VELOCITY; BLOOD PRESSURE; FREE RADICALS; HEMOGLOBINS; MALE; NITRIC OXIDE; NITRITES; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION; RATS, WISTAR; VASODILATION;

EID: 84896701723     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.255687     Document Type: Article

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