Cytotoxicity of gemcitabine-loaded-microemulsions in breast and colon cancer cells

Tropical Journal of Pharmaceutical Research

Volumn 13, Issue 2, 2014, Pages 217-224

  Alkhatib, Mayson H ^a   Alkhayyal, Norah S ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Apoptosis; HCT116 colon cancer cells; Hemolysis; MCF 7 breast cancer cells; Microemulsion; Sulphorhodamine B assay

Indexed keywords

GEMCITABINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROEMULSION; MICROSCOPY;

EID: 84896701127     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v13i2.8     Document Type: Article

References (20)

1. Thurston, DE. Chemistry and Pharmacology of Anticancer Drugs, CRC Press, Taylor and Francis Group, LLC; Boca Raton, FL; 2007; p 312.
2. Arias JL, Reddy H, Couvreur P. Superior preclinical efficacy of gemcitabine developed as chitosan nanoparticulate system, Biomacromolecules 2011; 12: 97-104.
3. Vandana M, Sahoo, SK. Long circulation and cytotoxicity of PEGylated gemcitabine and its potential for the treatment of pancreatic cancer, Biomaterials 2010; 31(35): 9340-9356.
4. Hodge LS, Taub ME, Tracy TS. Effect of its deaminated metabolite, 2′, m2′-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells, Biochem Pharmacol 2011; 81(7): 950-956.
5. Reddy LH, Couvreur P. Novel approaches to deliver gemcitabine to cancers, Curr Pharm 2008; 14: 1124-1137.
6. Celano M, Calvagno MG, Bulotta S, Paolino D, Arturi F, Rotiroti D, Filetti S, Fresta M, Russo D. Cytotoxic effects of Gemcitabine-loaded liposomes in human anaplastic thyroid carcinoma cells, BMC Cancer 2004; 4: 63-67.
7. Patra CR, Bhattacharya R, Wang E, Katarya A, Lau JS, Dutta S, Muders M, Wang S, Buhrow SA, Safgren SL, et al. Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent, Cancer Res 2008; 68(6): 1970-1978.
8. Arsawang U, Saengsawang O, Rungrotmongkol T, Sornmee P, Wittayanarakul K, Remsungnen T, Hannongbua S. How do carbon nanotubes serve as carriers for gemcitabine transport in a drug delivery system? J. Mol Graphics Modell 2011; 29: 591-596.
9. Denlinger CE, Rundall BK, Keller MD, Jones DR. Proteasome Inhibition Sensitizes Non-Small-Cell Lung Cancer to Gemcitabine-Induced Apoptosis, Ann Thorac Surg 2011; 78: 1207-1214.
10. Clegg A, Scott DA, Sidhu M, Hewitson P, Waugh N. A rapid and systematic review of the clinical effectiveness and costeffectiveness of paclitaxel, docetaxel, gemcitabine and vinorelbine in non-small- cell lung cancer, Health Technol Assess 2001; 5(32): 1-110.
11. Tsai YH, Hsieh YH, Huang YB, Chang JS, Huang CT, Wu PC. Microemulsions for Intravesical Delivery of Gemcitabine, Chem Pharm Bull 2010; 58(11): 1461-1465.
12. Alkhatib M, Albishi H, Mahassni S. Impact of Nanoparticles on Cancer Therapy. Trop J Pharm Res 2012; 11(6): 1001-1011.
13. Bulmus V, Woodward M, Lin L, Murthy N, Stayton P, Hoffman, A. A New pH-responsive and Glutathione-reactive, Endosomal Membrane-disruptive Polymeric Carrier for Cntracellular Delivery of Biomolecular Drugs, J Control Release 2003; 93: 105-120.
14. Alkhatib M., Albishi H. In vitro evaluation of antitumor activity of doxorubicin-loaded nanoemulsion in MCF-7 human breast cancer cells. J Nanopart Res 2013; 15: 1489-1503.
15. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren J., Bokesch H, Kenney S, Boyd MR. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990; 82: 1107-1112.
16. Von Der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, Bodrogi I, Albers P, Knuth A, Lippert CM, et al. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 2000; 18 (17): 3068.
17. Singh R, Mehra NK, Jain V, Jain NK. Gemcitabine-loaded smart carbon nanotubes for effective targeting to cancer cells. J. Drug Target 2013; 21(6): 581-92.
18. Wilk K, Zielinska K, Jarzycka A, Pietkiewicz. Human Erythrocyte Hemolysis Induced by Bioinspired Sugar Surfactants. Prog Coll Pol Sci 2011; 138: 189-192.
19. Li Y, Le Maux S, Xiao H, McClements DJ. Emulsion based delivery systems for tributyrin, a potential colon cancer preventative agent. J Agric Food Chem 2009; 57 (19): 9243-9249.
20. Yang D, Yang F, Hu J, Long J, Wang C, Fu D, Ni Q. Hydrophilic multi-walled carbon nanotubes decorated with magnetite nanoparticles as lymphatic targeted drug delivery vehicles, Chem Commun 2009; 29: 4447-4449.