Using 15N-ammonium to characterise and map potassium binding sites in proteins by NMR spectroscopy

ChemBioChem

Volumn 15, Issue 4, 2014, Pages 543-548

  Werbeck, Nicolas D ^a   Kirkpatrick, John ^a   Reinstein, Jochen ^b   Hansen, D Flemming ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

ammonium; enzyme catalysis; HDAC; Hsp70; NMR spectroscopy; potassium binding

Indexed keywords

HISTONE DEACETYLASE 8; NITROGEN 15; POTASSIUM; AMMONIA; AMMONIUM DERIVATIVE; HDAC8 PROTEIN, HUMAN; HEAT SHOCK PROTEIN 70; HISTONE DEACETYLASE; NITROGEN; RECOMBINANT PROTEIN; REPRESSOR PROTEIN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STABILITY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; MOLECULAR PROBE; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; BIOSYNTHESIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME CATALYSIS; GENETICS; HDAC; HSP70; HUMAN; METABOLISM; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM BINDING; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

AMMONIUM; ENZYME CATALYSIS; HDAC; HSP70; NMR SPECTROSCOPY; POTASSIUM BINDING;

AMMONIUM COMPOUNDS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HISTONE DEACETYLASES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; NITROGEN ISOTOPES; POTASSIUM; PROTEIN BINDING; RECOMBINANT PROTEINS; REPRESSOR PROTEINS;

EID: 84896698339     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300700     Document Type: Article

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