Full recovery after severe serotonin syndrome, severe rhabdomyolysis, multi-organ failure and disseminated intravascular coagulopathy from MDMA

Heart and Lung: Journal of Acute and Critical Care

Volumn 43, Issue 2, 2014, Pages 117-119

  Davies, O ^a   Batajoo Shrestha, B ^a   Sosa Popoteur, J ^a   Olibrice, M ^a  

^a HARLEM HOSPITAL CENTER   (United States)

Author keywords

Ecstasy; Hyperthermia; MDMA; Serotonin; Toxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; BICARBONATE; ETOMIDATE; MIDAZOLAM; PROPOFOL; ROCURONIUM;

ADULT; ARTICLE; ASIAN AMERICAN; ASSISTED VENTILATION; BODY TEMPERATURE; CASE REPORT; CLINICAL EXAMINATION; CONVALESCENCE; DELIRIUM; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; GLASGOW COMA SCALE; HEMODIALYSIS; HUMAN; INGESTION; LABORATORY TEST; MALE; METABOLIC ACIDOSIS; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROGNOSIS; RHABDOMYOLYSIS; RIGIDITY; SEROTONIN SYNDROME; SURVIVOR; TACHYCARDIA; YOUNG ADULT;

ECSTASY; HYPERTHERMIA; MDMA; SEROTONIN; TOXICITY;

DISSEMINATED INTRAVASCULAR COAGULATION; HALLUCINOGENS; HUMANS; MALE; MULTIPLE ORGAN FAILURE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RENAL DIALYSIS; RHABDOMYOLYSIS; SEROTONIN SYNDROME; YOUNG ADULT;

EID: 84896694593     PISSN: 01479563     EISSN: 15273288     Source Type: Journal    
DOI: 10.1016/j.hrtlng.2013.11.009     Document Type: Article

References (12)

1. Drug Facts 2012, U.S. Department of Health and Human Services. National Institute on Drug Abuse, MDMA ("ecstasy"), Accessed 18.01.13. http://www.drugabuse.gov/sites/default/files/mdma_0.pdf.
2. Hall A.P., Henry J.A. Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. Br J Anaesth 2006, 96(6):678-685.
3. Bodner R.A., Lynch T., lewis L., et al. Serotonin syndrome. Neurology 1995, 45:219-223.
4. Mallick A., Bodenham A.R. MDMA induced hyperthermia: a survivor with aninitial body temperature of 42.9 degrees C. JAccid Emerg Med 1997, 14(5):336-338.
5. Boyer E.W., Shannon M. The serotonin syndrome. NEngl J Med 2005, 352:1112-1120.
6. Dunkley E.J., Isbister G.K., Sibbritt D., et al. The Hunter serotonin toxicity criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM 2003, 96:635.
7. Nadkarni G.N., Hoskote S.S., Piotrkowski J., Annapureddy N. Case report: serotonin syndrome, disseminated intravascular coagulation, and hepatitis after single ingestion of MDMA in an Asian woman. Am J Ther 2012, Jun 16, [Epub ahead of print].
8. Dvir Y., Smallwood P. Serotonin syndrome a complex but easily avoidable condition. Gen Hosp Psychiatry 2008, 30:284-287.
9. Aitchison K.J., Tsapakis E.M., Huezo-Diaz P., Kerwin R.W., Forsling M.L., Wolff K. Ecstasy (MDMA)-induced hyponatremia is associated with genetic variants in CYP2D6 and COMT. JPsychopharmacol 2012, 26(3):408-418.
10. Gillman P.K. The serotonin syndrome and its treatment. JPsychopharmacol 1999, 13:100-109.
11. Carrasco G., Cabre L., Sobrepere G., et al. Synergistic sedation with propofol and midazolam in intensive care patients after coronary artery bypass grafting. Crit Care Med 1998, 26(5):844-851.
12. Graudins A., Stearman A., Chan B. Treatment of the serotonin syndrome with cyproheptadine. JEmerg Med 1998, 16:615.