Serotonin syndrome: a complex but easily avoidable condition

General Hospital Psychiatry

Volumn 30, Issue 3, 2008, Pages 284-287

  Dvir, Yael ^a   Smallwood, Patrick ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Antidepressants; Atypical antipsychotics; Drug interactions; Opiates; Serotonin syndrome

Indexed keywords

DIAZEPAM; FLUOXETINE; METOPROLOL; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; OLANZAPINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; TRAMADOL; VENLAFAXINE;

ADULT; AGITATION; ANXIETY; ARTICLE; CASE REPORT; CLONUS; CONFUSION; DEPRESSION; DIAPHORESIS; DRUG WITHDRAWAL; FEMALE; FEVER; HUMAN; HYPERREFLEXIA; MYOCLONUS; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; OPIATE ADDICTION; SEROTONIN SYNDROME; SYMPTOMATOLOGY; TACHYCARDIA; TACHYPNEA; TREMOR;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIPSYCHOTIC AGENTS; ANXIETY DISORDERS; BENZODIAZEPINES; BUPROPION; CYCLOHEXANOLS; DELAYED-ACTION PREPARATIONS; DEPRESSIVE DISORDER; DRUG THERAPY, COMBINATION; FEMALE; FLUOXETINE; HUMANS; METHADONE; MIDDLE AGED; OPIOID-RELATED DISORDERS; SEROTONIN SYNDROME; SEROTONIN UPTAKE INHIBITORS; SUBSTANCE ABUSE, INTRAVENOUS;

EID: 42149181114     PISSN: 01638343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2007.09.007     Document Type: Article

References (17)

1. Boyer E.W., and Shannon M. The serotonin syndrome. N Engl J Med 352 (2005) 1112-1120
2. Birmes P., Coppin D., Schmitt L., and Lauque D. Serotonin syndrome: a brief review. Can Med Assoc J 168 (2003) 1439-1442
3. Vaswani M., FarzanaKadar L., and Subramanyam R. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 85-102
4. Stahl S. Mechanism of action of serotonin selective reuptake inhibitors: serotonin receptors and pathways mediate therapeutic effects and side effects. J Affect Disord 51 (1998) 215-235
5. Houlihan D. Serotonin syndrome resulting from coadministration of tramodol, venlafaxine, and mirtazapine. Ann Pharmacother 38 (2004) 411-413
6. Fox M.A., Jensen C.L., and Gallagher P.S. Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. Neuropharmacology 53 (2007) 643-656
7. Gutierrez M.A., Stimmel G.L., and Aiso J.Y. Venlafaxine: a 2003 update. Clin Ther 25 (2003) 2138-2154
8. Pan J.J., and Winston W.S. Serotonin syndrome induced by low-dose venlafaxine. Ann Pharmacother 37 (2003) 209-211
9. Dougherty J.A., Young H., and Shafi T. Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine. Ann Pharmacother 36 (2002) 1647-1648
10. Duggal H.S., and Fetchko J. Serotonin syndrome and atypical antipsychotics. Am J Psychiatry 159 4 (2002) 672-673
11. Gillman P.K. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. Br J Anaesth 95 (2005) 434-441
12. Toombs J.D., and Kral L.A. Methadone treatment for pain states. Am Fam Physician 71 7 (2005) 1353-1358
13. Bowdle T.A. Adverse effects of opioid agonists and agonist-antagonists in anaesthesia. Drug Saf 19 3 (1998) 173-189
14. Bowers M.B., and Kleber H.D. Methadone increases mouse brain 5-hydroxyindoleacetic acid. Nature 229 (1971) 134-135
15. Codd E.E., Shank R.P., Schupsky J.J., and Raffa R.B. Serotonin and norepinephrine uptake inhibition activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther 274 3 (1995) 1263-1270
16. Tissot T.A. Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use. Anesthesiology #32;98 (2003) 1511-1512
17. Morales N., and Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics 46 3 (2005) 274-275