Ins and outs of T-channel structure function

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 4, 2014, Pages 627-633

  Perez Reyes, Edward ^a   Lee, Jung Ha ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Sogang University   (South Korea)

Author keywords

Copper; Epilepsy; Neurophysiology; Nickel; T type calcium channel; Zinc

Indexed keywords

CALCIUM CHANNEL T TYPE; CALCIUM ION; HISTIDINE; TRANSCRIPTION FACTOR; VOLTAGE GATED CALCIUM CHANNEL;

BINDING AFFINITY; BINDING SITE; DEPOLARIZATION; ELECTRIC POTENTIAL; GENERALIZED EPILEPSY; HIPPOCAMPAL NEURONAL CULTURE; HUMAN; METAL BINDING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVIEW; SEIZURE SUSCEPTIBILITY; ANIMAL; CHANNEL GATING; CHEMISTRY; GENETIC VARIABILITY; MUTATION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE;

ANIMALS; BINDING SITES; CALCIUM CHANNELS, T-TYPE; GENETIC VARIATION; HUMANS; ION CHANNEL GATING; MUTATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84896548739     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1419-5     Document Type: Review

References (61)

1. Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (2004) Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science 303(5655):197-202. doi:10.1126/science. 1089845 (Pubitemid 38057563)
2. 2+ channels. FEBS Lett 579(18):3907 -3912. doi:10.1016/j.febslet. 2005.06.008
3. 2+ channels. J Biol Chem 283(13):8136-8144. doi:10.1074/jbc. M708761200
4. + channel gating. JMol Biol 381(3):569-580. doi:10.1016/j.jmb.2008.06.010
5. Baumgart JP, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E (2008) I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS ONE 3: e2976. doi:10.1371/journal. pone.0002976
6. Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T (1996) Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J 15(21):5789-5795 (Pubitemid 26375500)
7. 2+ channels. Physiol Rev 90(4):1461-1506. doi:10.1152/physrev.00057. 2009
8. Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F (2005) Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature 436(7052):852-856. doi:10.1038/nature03888 (Pubitemid 41160644)
9. Chen YC, Lu JJ, Pan H, Zhang YH,Wu HS, Xu KM, Liu XY, Jiang YW, Bao XH, Yao ZJ, Ding KY, LoWHY, Qiang BQ, Chan P, Shen Y, Wu XR (2003) Association between genetic variation of CACN A1H and childhood absence epilepsy. Ann Neurol 54(2):239-243. doi:10.1002/ana.10607 (Pubitemid 36909623)
10. 1G is not associated with childhood absence epilepsy in the Chinese Han population. Neurosci Lett 341(1):29-32. doi:10.1016/S0304-3940(03)00124-1
11. 2+ channel gene family. Circ Res 83(1):103-109. doi:10.1161/01.RES.83.1.103
12. 2d and other accessory subunits on expression and properties of the calcium channel a1G. J Physiol Lond 519:35-45. doi:10.1111/j.1469-7793.1999.0035o.x
13. T window. J Neurosci 30(1):99-109. doi:10.1523/JNEUROSCI.4305-09. 2010
14. Dubel SJ, Altier C, Chaumont S, Lory P, Bourinet E, Nargeot J (2004) Plasma membrane expression of T-type calcium channel a1 subunits is modulated by HVA auxiliary subunits. J Biol Chem 279(28):29263-29269. doi:10.1074/jbc. M313450200 (Pubitemid 38915802)
15. Eckle V-S, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E (2013) Mechanisms by which a CACNA1H mutation found in epilepsy patients increases seizure susceptibility. J Physiol Lond. doi:10.1113/jphysiol. 2013.264176
16. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL (2009) Genetic enhancement of thalamocortical network activity by elevating a1G-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci 29(6):1615 - 1625. doi:10.1523/JNEUROSCI.2081-08.2009
17. Frazier CJ, Serrano JR, George EG, Yu X, Viswanathan A, Perez-Reyes E, Jones SW (2001) Gating kinetics of the a1I T-type calcium channel. J Gen Physiol 118(5):457 - 470. doi:10.1085/jgp.118.5.457
18. Ginalski K, Elofsson A, Fischer D, Rychlewski L (2003) 3D-Jury: a simple approach to improve protein structure predictions. Bioinformatics 19(8):1015 - 1018. doi:10.1093/bioinformatics/btg124
19. Hagiwara N, Irisawa H, Kameyama M (1988) Contribution of two types of calcium currents to the pacemaker potentials of rabbit sinoatrial node cells. J Physiol Lond 395:233-253 (Pubitemid 18029194)
20. Heron SE, Khosravani H, Varela D, Bladen C, Williams TC, Newman MR, Scheffer IE, Berkovic SF, Mulley JC, Zamponi GW (2007) Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants. Ann Neurol 62(6):560-568. doi:10.1002/ana.21169
21. Huguenard JR (1996) Low threshold calcium currents in central nervous system neurons. Annu Rev Physiol 58:329-348. doi:10.1146/annurev.ph.58.030196. 001553
22. Jeong SW, Park BG, Park JY, Lee JW, Lee JH (2003) Divalent metals differentially block cloned T-type calcium channels. Neuroreport 14(11):1537-1540
23. v2.3 calcium channel. FEBS Lett 581(30):5774-5780. doi:10.1016/j.febslet.2007.11.045
24. v3.2 T-type calcium channels. J Biol Chem 281(8):4823-4830. doi:10.1074/jbc.M510197200
25. v3.2 T-type calcium channels. J Biol Chem 3271-3281:3271-3281. doi:10.1074/jbc.M109.067660
26. v3.3 channel is determined by the gating brake in the I-II loop. Pflugers Arch 461(4):461-468. doi:10.1007/s00424-011-0937-2
27. Klassen T, Davis C, Goldman A, Burgess D, Chen T, Wheeler D, McPherson J, Bourquin T, Lewis L, Villasana D, Morgan M, Muzny D, Gibbs R, Noebels J (2011) Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell 145(7):1036-1048. doi:10.1016/j.cell.2011.05.025
28. Lacinová L, Klugbauer N, Hofmann F (2002) Gating of the expressed Cav3.1 calcium channel. FEBS Lett 531(2):235-240. doi:10.1016/S0014-5793(02) 03509-3 (Pubitemid 35341200)
29. Lam A, Chikina M, McNulty M, Glaaser I, Hanck D (2005) Role of domain IV/S4 outermost arginines in gating of T-type calcium channels. Pflugers Arch 451(2):349-361. doi:10.1007/s00424-005-1407-5 (Pubitemid 41586710)
30. 13Carbon-nuclear magnetic resonance investigation of the Cu (II)-binding to the native sequence peptide representing the Cu (II)-transport site of human albumin. Evidence for the involvement of the beta-carboxyl side chain of aspartyl residue. J Biol Chem 255(16):7563-7568
31. + channels. PLoS Biol 7(3):e47. doi:10.1371/journal.pbio.1000047
32. Lee JH, Daud AN, Cribbs LL, Lacerda AE, Pereverzev A, Klöckner U, Schneider T, Perez-Reyes E (1999) Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci 19(6):1912-1921 (Pubitemid 29133369)
33. Lee JH, Gomora JC, Cribbs LL, Perez-Reyes E (1999) Nickel block of three cloned T-type calcium channels: low concentrations selectively block a1H. Biophys J 77(6):3034-3042. doi:10.1016/S0006-3495(99)77134-1
34. v3.2) in major pelvic ganglion neurons. J Neurophysiol 87(6):2844-2850
35. + channel. Nature 353(6346):752-756. doi:10.1038/353752a0
36. Llinás R, Ribary U, Jeanmonod D, Cancro R, Kronberg E, Schulman J, Zonenshayn M, Magnin M, Morel A, Siegmund M (2001) Thalamocortical dysrhythmia I. Functional and imaging aspects. Thalamus Relat Syst 1(3):237-244. doi:10.1016/S1472-9288(01)00023-1 (Pubitemid 33665033)
37. v3.1. J Physiol Lond 537(1):27-34. doi:10.1111/j.1469-7793.2001.0027k.x
38. v3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci 24(9):2581-2594. doi:10.1111/j.1460-9568.2006.05136.x
39. 2+ current by tachykinin receptor activation. J Gen Physiol 134(5):385-396. doi:10.1085/jgp.200910204
40. v3.2 T-type calcium channel mutations linked to childhood absence epilepsy. Epilepsia 47(3):655-658. doi:10.1111/j.1528-1167.2006.00482.x
41. Perez-Reyes E (2003) Molecular physiology of low-voltage-activated T-type calcium channels. Physiol Rev 83(1):117-161. doi:10.1152/physrev.00018.2002
42. V3 T-type calcium channels. Channels 4:453-458. doi:10.4161/chan.4.6.12889
43. Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (1998) Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391(6670):896-900. doi:10.1038/36110 (Pubitemid 28157667)
44. 2+ channels. J Biol Chem 281(51):39424-39436. doi:10.1074/jbc. M607405200
45. 2+ channel isoforms. J Pharmacol Exp Ther 347(2):310-317. doi:10.1124/jpet.113.207936
46. v2.3 calcium channels. J Gen Physiol 139(3):219- 234. doi:10.1085/jgp.201110699
47. Shi C, Soldatov NM (2002) Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel. J Biol Chem 277(9):6813-6821. doi:10.1074/jbc.M110524200 (Pubitemid 34953063)
48. v1.2 calciumchannel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119(1):19-31. doi:10.1074/jbc.M110524200
49. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT (2006) CACNA1H mutations in autism spectrum disorders. J Biol Chem 281(31):22085-22091. doi:10.1074/jbc.M603316200 (Pubitemid 44181912)
50. Stotz SC, Jarvis SE, Zamponi GW (2004) Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels. J Physiol Lond 554(Pt 2):263-273. doi:10.1113/jphysiol.2003.047068 (Pubitemid 38181341)
51. Talavera K, Nilius B (2006) Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels. Pflugers Arch 453(2):189-201. doi:10.1007/s00424-006-0129-7 (Pubitemid 44630453)
52. Talley EM, Cribbs LL, Lee JH, Daud A, Perez-Reyes E, Bayliss DA (1999) Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci 19(6):1895-1911 (Pubitemid 29133368)
53. Thevenod F, Jones SW (1992) Cadmium block of calcium current in frog sympathetic neurons. Biophys J 63:162-168. doi:10.1016/S0006-3495(92)81575-8
54. 2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol 79(1):240-252
55. 2+ channels: a paradigm for childhood absence epilepsy. J Neurosci 27(2):322-330. doi:10.1523/jneurosci.1817-06.2007
56. Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005) Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 25(19):4844-4855. doi:10.1523/JNEUROSCI.0847-05.2005 (Pubitemid 40667526)
57. 12.2 subunit is critical for its regulation of channel activity. PLoS ONE 3(10):e3560
58. West AE, Greenberg ME (2011) Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb Perspect Biol 3 (6), doi:10.1101/cshperspect.a005744
59. Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419(6902):35-42. doi:10.1038/nature00978
60. Zamponi GW, Bourinet E, Snutch TP (1996) Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites. J Membr Biol 151:77 - 90. doi:10.1007/s002329900059
61. Zhang Y, Mori M, Burgess DL, Noebels JL (2002) Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci 22(15):6362-6371 (Pubitemid 35386391)