PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings

Molecular and Cellular Biochemistry

Volumn 389, Issue 1-2, 2014, Pages 69-77

  Ryu, Byung Jun ^b   Lee, Hyuk ^b   Kim, Seong Ho ^b   Heo, Jung Nyoung ^b   Choi, Sik Won ^b   Yeon, Jeong Tae ^c   Lee, Jeongmin ^d   Lee, Jongsung ^e   Cho, Jae Youl ^f   Kim, Seong Hwan ^b   Lee, Sang Yeol ^a  

^a Gachon University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Sunchon National University   (South Korea)

^d Korea Centers for Disease Control and Prevention   (South Korea)

^e Eulji University   (South Korea)

^f Sungkyunkwan University   (South Korea)

Author keywords

CREB; Human lung cancer; Matrix metalloproteinases; Metastasis; NF B; p21 activated kinase 4; PF 3758309; Catenin

Indexed keywords

ANTIMETASTATIC AGENT; BETA CATENIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; P21 ACTIVATED KINASE 4; PF 3758309; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG STRUCTURE; ENZYME INACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG ADENOCARCINOMA; METASTASIS INHIBITION; REGULATORY MECHANISM; TUMOR INVASION;

BETA CATENIN; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOWN-REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NF-KAPPA B; P21-ACTIVATED KINASES; PYRAZOLES; PYRROLES; SIGNAL TRANSDUCTION;

EID: 84896543038     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1928-8     Document Type: Article

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