Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets

mAbs

Volumn 6, Issue 2, 2014, Pages 460-473

  McCutcheon, Krista M ^a   Gray, Julia ^b   Chen, Natalie Y ^c   Liu, Keyi ^c   Park, Minha ^d   Ellsworth, Stote ^c   Tripp, Ralph A ^e   Mark Tompkins, S ^e   Johnson, ScottK ^e   Samet, Shelly ^e   Pereira, Lenore ^f   Kauvar, Lawrence M ^d  

^a GILEAD SCIENCES   (United States)

^b Archaogen   (United States)

^c Trellis Bioscience   (United States)

^d Crystal Bioscience Inc   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Broadly protective antibodies; Cytomegalovirus; Fusion; Human antibodies; Immunoglobulin germline; Influenza; Monoclonal antibodies; Neutralizing antibodies; Viral epitopes

Indexed keywords

EPITOPE; GLYCOPROTEIN B; INFLUENZA VIRUS HEMAGGLUTININ; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

ANTIBODY PRODUCTION; ANTIBODY SCREENING; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CRYSTAL STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN CYTOMEGALOVIRUS; HUMORAL IMMUNITY; IMMUNE RESPONSE; INFLUENZA A; INNATE IMMUNITY; MEMORY CELL; MULTIPLEXED SCREENING; NONHUMAN; SOMATIC MUTATION; VIRUS ENTRY; VIRUS NEUTRALIZATION;

BROADLY PROTECTIVE ANTIBODIES; CYTOMEGALOVIRUS; FUSION; HUMAN ANTIBODIES; IMMUNOGLOBULIN GERMLINE; INFLUENZA; MONOCLONAL ANTIBODIES; NEUTRALIZING ANTIBODIES; VIRAL EPITOPES;

ANTIBODIES, BLOCKING; ANTIBODY AFFINITY; ANTIGENS, VIRAL; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL LINE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EPITOPES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNE EVASION; IMMUNITY, HUMORAL; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS; INFLUENZA, HUMAN; PROTEIN CONFORMATION; VIRAL ENVELOPE PROTEINS;

EID: 84896530101     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.27760     Document Type: Article

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