ACTN3 R577X polymorphism and explosive leg-muscle power in elite basketball players

International Journal of Sports Physiology and Performance

Volumn 9, Issue 2, 2014, Pages 226-232

  Garatachea, Nuria ^a   Verde, Zoraida ^b   Santos Lozano, Alejandro ^c   Yvert, Thomas ^b   Rodriguez Romo, Gabriel ^d   Sarasa, Francisco J ^e   Hernández Sánchez, Sonsoles ^f   Santiago, Catalina ^b   Lucia, Alejandro ^b  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^c UNIVERSITY OF LEÓN   (Spain)

^d UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^e UNIVERSIDAD SAN JORGE   (Spain)

^f EUROPEAN UNIVERSITY MIGUEL DE CERVANTES   (Spain)

Author keywords

Basketball; Genotype; Jump; Power; actinin 3

Indexed keywords

ACTININ; ACTN3 PROTEIN, HUMAN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; ATHLETIC PERFORMANCE; BASKETBALL; CASE CONTROL STUDY; CAUCASIAN; CHI SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; MALE; MUSCLE CONTRACTION; MUSCLE STRENGTH; PHENOTYPE; PHYSIOLOGY; RISK; SKELETAL MUSCLE; SPAIN; STATISTICAL MODEL; YOUNG ADULT;

ACTININ; ADULT; ANALYSIS OF VARIANCE; ATHLETIC PERFORMANCE; BASKETBALL; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MUSCLE CONTRACTION; MUSCLE STRENGTH; MUSCLE, SKELETAL; ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; SPAIN; YOUNG ADULT;

EID: 84896522025     PISSN: 15550265     EISSN: None     Source Type: Journal    
DOI: 10.1123/IJSPP.2012-0331     Document Type: Article

References (30)

1. Squire JM. Architecture and function in the muscle sarcomere. Curr Opin Struct Biol. 1997;7(2):247-257. doi:10.1016/S0959-440X(97)80033-4
2. North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH. A common nonsense mutation results in alpha-actinin-3 deficiency in the general population. Nat Genet. 1999;21(4):353-354. doi:10.1038/7675
3. MacArthur DG, Seto JT, Raftery JM, et al. Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet. 2007;39(10):1261-1265. doi:10.1038/ng2122
4. Eynon N, Ruiz JR, Femia P, et al. The ACTN3 R577X polymorphism across three groups of elite male European athletes. PLoS ONE. 2012;7(8):e43132. doi:10.1371/journal.pone.0043132
5. Yang N, MacArthur DG, Gulbin JP, et al. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet. 2003;73(3):627-631. doi:10.1086/377590
6. Lucia A, Gomez-Gallego F, Santiago C, et al. ACTN3 genotype in professional endurance cyclists. Int J Sports Med. 2006;27(11):880-884. doi:10.1055/s-2006-923862
7. Ben Abdelkrim N, El Fazaa S, El Ati J. Time-motion analysis and physiological data of elite under-19-yearold basketball players during competition. Br J Sports Med. 2007;41(2):69-75 discussion. doi:10.1136/ bjsm.2006.032318
8. Ziv G, Lidor R. Physical attributes, physiological characteristics, on-court performances and nutritional strategies of female and male basketball players. Sports Med. 2009;39(7):547-568. doi:10.2165/00007256- 200939070-00003
9. Ostojic SM, Mazic S, Dikic N. Profiling in basketball: Physical and physiological characteristics of elite players. J Strength Cond Res. 2006;20(4):740-744
10. Hoffman JR, Tennenbaum G, Maresh CM, Kraemer WJ. Relationship between athletic performance tests and playing time in elite college basketball players. J Strength Cond Res. 1996;10:67-71.
11. MacArthur DG, North KN. A gene for speed?: the evolution and function of alpha-actinin-3. Bioessays. 2004;26(7):786-795. doi:10.1002/bies.20061
12. Chanock SJ, Manolio T, Boehnke M, et al. Replicating genotype-phenotype associations. Nature. 2007;447(7145):655-660. doi:10.1038/447655a
13. Young WB, MacDonald C, Flowers MA. Validity of doubleand single-leg vertical jumps as tests of leg extensor muscle function. J Strength Cond Res. 2001;15(1):6-11
14. Santiago C, Rodriguez-Romo G, Gomez-Gallego F, et al. Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults? Scand J Med Sci Sports. 2010;20(5):771-778. doi:10.1111/j.1600-0838.2009.01017.x
15. Bosco C, Mognoni P, Luhtanen P. Relationship between isokinetic performance and ballistic movement. Eur J Appl Physiol Occup Physiol. 1983;51(3):357-364. doi:10.1007/BF00429072
16. Bosco C, Viitasalo JT, Komi PV, Luhtanen P. Combined effect of elastic energy and myoelectrical potentiation during stretch-shortening cycle exercise. Acta Physiol Scand. 1982;114(4):557-565. doi:10.1111/j.1748-1716.1982.tb07024.x
17. Ziv G, Lidor R. Vertical jump in female and male basketball players - a review of observational and experimental studies. J Sci Med Sport. 2010;13(3):332-339. doi:10.1016/j.jsams.2009.02.009
18. Bell W, Colley JP, Evans WD, Darlington SE, Cooper SM. ACTN3 genotypes of Rugby Union players: Distribution, power output and body composition. Ann Hum Biol. 2012;39(1):19-27. doi:10.3109/03014460.2011 .632648
19. Delmonico MJ, Zmuda JM, Taylor BC, et al. Association of the ACTN3 genotype and physical functioning with age in older adults. J Gerontol A Biol Sci Med Sci. 2008;63(11):1227-1234. doi:10.1093/ gerona/63.11.1227
20. McCauley T, Mastana SS, Hossack J, Macdonald M, Folland JP. Human angiotensin-converting enzyme I/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties. Exp Physiol. 2009;94(1):81-89. doi:10.1113/expphysiol.2008.043075
21. Ruiz JR, Fernández del Valle M, Verde Z, et al. ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players. Scand J Med Sci Sports. 2011;21(6):e34-e41. doi:10.1111/j.1600- 0838.2010.01134.x
22. Clarkson PM, Devaney JM, Gordish-Dressman H, et al. ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol. 2005;99(1):154-163. doi:10.1152/ japplphysiol.01139. 2004
23. Vincent B, De Bock K, Ramaekers M, et al. ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics. 2007;32(1):58-63. doi:10.1152/physiolgenomics.00173.2007
24. Delmonico MJ, Kostek MC, Doldo NA, et al. Alphaactinin- 3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. J Gerontol A Biol Sci Med Sci. 2007;62(2):206-212. doi:10.1093/gerona/62.2.206
25. Gineviciene V, Pranculis A, Jakaitiene A, Milasius K, Kucinskas V. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas). 2011;47(5):284-290
26. Alfred T, Ben-Shlomo Y, Cooper R, et al. ACTN3 genotype, athletic status, and life course physical capability: Meta-analysis of the published literature and findings from nine studies. Hum Mutat. 2011;32(9):1008-18. doi:10.1002/humu.21526
27. Ruiz JR, Gomez-Gallego F, Santiago C, et al. Is there an optimum endurance polygenic profile? J Physiol. 2009;587(Pt 7):1527-1534. doi:10.1113/jphysiol.2008.166645
28. Santiago C, Ruiz JR, Muniesa CA, Gonzalez-Freire M, Gomez-Gallego F, Lucia A. Does the polygenic profile determine the potential for becoming a world-class athlete?: insights from the sport of rowing. Scand J Med Sci Sports. 2010;20(1):e188-e194. doi:10.1111/j.1600-0838.2009.00943.x
29. Attia J, Ioannidis JP, Thakkinstian A, et al. How to use an article about genetic association: C: what are the results and will they help me in caring for my patients? JAMA. 2009;301(3):304-308. doi:10.1001/jama.2008.993
30. Hong EP, Park JW. Sample size and statistical power calculations. Genomics Inform. 2012;10(2):117-122. doi:10.5808/GI.2012.10.2.117