ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players

Scandinavian Journal of Medicine and Science in Sports

Volumn 21, Issue 6, 2011, Pages

  Ruiz, J R ^a   Fernandez del Valle M ^b   Verde, Z ^b   Diez Vega I ^b   Santiago, C ^b   Yvert, T ^b   Rodriguez Romo G ^c   Gomez Gallego F ^b   Molina, J J ^b   Lucia, A ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^c UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

Author keywords

actinin 3; Counter movement jump; Genotype; Squat jump; Volleyball

Indexed keywords

ACTININ; ACTN3 PROTEIN, HUMAN;

ADULT; ARTICLE; ATHLETE; ATHLETIC PERFORMANCE; COMPARATIVE STUDY; DNA SEQUENCE; FAST MUSCLE FIBER; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; LEG; MALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE STRENGTH; PHYSIOLOGY; SPAIN; VOLLEYBALL;

ACTININ; ATHLETES; ATHLETIC PERFORMANCE; FEMALE; HUMANS; LEG; MALE; MUSCLE CONTRACTION; MUSCLE FIBERS, FAST-TWITCH; MUSCLE STRENGTH; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA; SPAIN; VOLLEYBALL; YOUNG ADULT;

EID: 82455186875     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2010.01134.x     Document Type: Article

References (34)

1. Ashley CD, Weiss LW.Vertical jump performance and selected physiological characteristics of women. J Strength Cond Res 1994: 8: 5-11.
2. Bosco C, Mognoni P, Luhtanen P.Relationship between isokinetic performance and ballistic movement. Eur J Appl Physiol Occup Physiol 1983: 51: 357-364.
3. Bosco C, Viitasalo JT, Komi PV, Luhtanen P.Combined effect of elastic energy and myoelectrical potentiation during stretch-shortening cycle exercise. Acta Physiol Scand 1982: 114: 557-565.
4. Brown LE, Weir JP.ASEP procedures recommendation I: Accurate assessment of muscular strength JEPonline. 2001: 4: 1-21.
5. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JFJr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS.Replicating genotype-phenotype associations. Nature 2007: 447: 655-660.
6. Clarkson PM, Devaney JM, Gordish-Dressman H, Thompson PD, Hubal MJ, Urso M, Price TB, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Hoffman EP.ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol 2005: 99: 154-163.
7. Delmonico MJ, Kostek MC, Doldo NA, Hand BD, Walsh S, Conway JM, Carignan CR, Roth SM, Hurley BF.Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. J Gerontol A Biol Sci Med Sci 2007: 62: 206-212.
8. Delmonico MJ, Zmuda JM, Taylor BC, Cauley JA, Harris TB, Manini TM, Schwartz A, Li R, Roth SM, Hurley BF, Bauer DC, Ferrell RE, Newman AB.Association of the ACTN3 genotype and physical functioning with age in older adults. J Gerontol A Biol Sci Med Sci 2008: 63: 1227-1234.
9. Druzhevskaya AM, Ahmetov II, Stratenkova IV, Rogozkin VAAssociation of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur J Appl Physiol 2008: 103: 631-634.
10. Eynon N, Duarte JA, Oliveira J, Sagiv M, Yamin C, Meckel Y, Sagiv M, Goldhammer E.ACTN3 R577X polymorphism and Israeli top-level athletes. Int J Sports Med 2009: 30: 695-698.
11. Lucia A, Gomez-Gallego F, Santiago C, Bandres F, Earnest C, Rabadan M, Alonso JM, Hoyos J, Cordova A, Villa G, Foster C.ACTN3 genotype in professional endurance cyclists. Int J Sports Med 2006: 27: 880-884.
12. Lucia A, Olivan J, Gomez-Gallego F, Santiago C, Montil M, Foster C.Citius and longius (faster and longer) with no alpha-actinin-3 in skeletal muscles?Br J Sports Med 2007: 41: 616-617.
13. MacArthur DG, North KN.A gene for speed? The evolution and function of alpha-actinin-3. Bioessays 2004: 26: 786-795.
14. MacArthur DG, Seto JT, Chan S, Quinlan KG, Raftery JM, Turner N, Nicholson MD, Kee AJ, Hardeman EC, Gunning PW, Cooney GJ, Head SI, Yang N, North KN.An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Hum Mol Genet 2008: 17: 1076-1086.
15. MacArthur DG, Seto JT, Raftery JM, Quinlan KG, Huttley GA, Hook JW, Lemckert FA, Kee AJ, Edwards MR, Berman Y, Hardeman EC, Gunning PW, Easteal S, Yang N, North KN.Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet 2007: 39: 1261-1265.
16. Marques MC, Gonzalez-Badillo JJ.In-season resistance training and detraining in professional team handball players. J Strength Cond Res 2006: 20: 563-571.
17. Marques MC, van den Tillaar R, Gabbett TJ, Reis VM, Gonzalez-Badillo JJ.Physical fitness qualities of professional volleyball players: determination of positional differences. J Strength Cond Res 2009: 23: 1106-1111.
18. Massidda M, Vona G, Calo CM.Association between the ACTN3 R577X polymorphism and artistic gymnastic performance in Italy. Genet Test Mol Biomarkers 2009: 13: 377-380.
19. McCauley T, Mastana SS, Hossack J, Macdonald M, Folland JP.Human angiotensin-converting enzyme I/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties. Exp Physiol 2009: 94: 81-89.
20. Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S, North K.Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet 2001: 10: 1335-1346.
21. Moran CN, Yang N, Bailey ME, Tsiokanos A, Jamurtas A, MacArthur DG, North K, Pitsiladis YP, Wilson RH.Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. Eur J Hum Genet 2007: 15: 88-93.
22. Niemi AK, Majamaa K.Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet 2005: 13: 965-969.
23. North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH.A common nonsense mutation results in alpha-actinin-3 deficiency in the general population. Nat Genet 1999: 21: 353-354.
24. Papadimitriou ID, Papadopoulos C, Kouvatsi A, Triantaphyllidis C.The ACTN3 gene in elite Greek track and field athletes. Int J Sports Med 2008: 29: 352-355.
25. Roth SM, Walsh S, Liu D, Metter EJ, Ferrucci L, Hurley BF.The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. Eur J Hum Genet 2008: 16: 391-394.
26. Ruiz JR, Gomez-Gallego F, Santiago C, Gonzalez-Freire M, Verde Z, Foster C, Lucia A.Is there an optimum endurance polygenic profile?J Physiol 2009: 587: 1527-1534.
27. Santiago C, Gonzalez-Freire M, Serratosa L, Morate FJ, Meyer T, Gomez-Gallego F, Lucia A.ACTN3 genotype in professional soccer players. Br J Sports Med 2008: 42: 71-73.
28. Santiago C, Rodriguez-Romo G, Gomez-Gallego F, Gonzalez-Freire M, Yvert T, Verde Z, Naclerio F, Altmae S, Esteve-Lanao J, Ruiz JR, Lucia A.Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults?Scand J Med Sci Sports 2009a: doi: DOI: 10.1111/j.1600-0838.2009.01017.x
29. Santiago C, Ruiz JR, Muniesa CA, Gonzalez-Freire M, Gomez-Gallego F, Lucia A.Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing. Scand J Med Sci Sports 2009b: 20: e188-e194.
30. van Rooij E, Liu N, Olson EN.MicroRNAs flex their muscles. Trends Genet 2008: 24: 159-166.
31. Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P, Thomis MA.ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics 2007: 32: 58-63.
32. Walsh S, Liu D, Metter EJ, Ferrucci L, Roth SM.ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J Appl Physiol 2008: 105: 1486-1491.
33. Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, North K.ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 2003: 73: 627-631.
34. Young WB, MacDonald C, Flowers MA.Validity of double- and single-leg vertical jumps as tests of leg extensor muscle function. J Strength Cond Res 2001: 15: 6-11.