The accuracy, precision and sustainability of different techniques for tablet subdivision: Breaking by hand and the use of tablet splitters or a kitchen knife

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 44-51

  Van Riet Nales, Diana A ^a   Doeve, Myrthe E ^a   Nicia, Agnes E ^a   Teerenstra, Steven ^a,c   Notenboom, Kim ^b   Hekster, Yechiel A ^a,c   Van Den Bemt, Bart J F ^c,d  

^a MEDICINES EVALUATION BOARD   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d SINT MAARTENSKLINIEK   (Netherlands)

Author keywords

Break mark; Medication; Pharmaceutical development; Tablet splitting; Weight uniformity

Indexed keywords

PARACETAMOL; TABLET;

ACCURACY; ADULT; ARTICLE; COMPLIANCE (PHYSICAL); CONTROLLED STUDY; FEMALE; HAND BREAKING; HAND FUNCTION; HEALTH CARE; HUMAN; KITCHEN KNIFE; PHARMACEUTICS; PRIORITY JOURNAL; TABLET; TABLET SPLITTER; YOUNG ADULT; DRUG LEGISLATION; KITCHEN; STANDARDS;

ACETAMINOPHEN; ADULT; COOKING AND EATING UTENSILS; FEMALE; HUMANS; LEGISLATION, DRUG; TABLETS; YOUNG ADULT;

EID: 84896507742     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.031     Document Type: Article

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