Tablet splitting of a narrow therapeutic index drug: A case with levothyroxine sodium

AAPS PharmSciTech

Volumn 11, Issue 3, 2010, Pages 1359-1367

  Shah, Rakhi B ^a   Collier, Jarrod S ^a,b   Sayeed, Vilayat A ^a   Bryant, Arthur ^a   Habib, Muhammad J ^b   Khan, Mansoor A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b HOWARD UNIVERSITY   (United States)

Author keywords

content uniformity; hand splitting; levothyroxine sodium; narrow therapeutic index; splitter; tablet splitting

Indexed keywords

DILUENT; DISINTEGRATING AGENT; EXCIPIENT; GLIDING AGENT; LEVOTHYROXINE SODIUM;

ARTICLE; DOSE RESPONSE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG OVERDOSE; DRUG POTENCY; DRUG STABILITY; DRUG UNDERDOSE; FRAGMENTATION REACTION; PRIORITY JOURNAL; TABLET FORMULATION; TABLET FRIABILITY;

DRUG COMPOUNDING; DRUG STABILITY; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TABLETS; THYROXINE;

EID: 78649903501     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9515-8     Document Type: Article

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