An efficient screening system for influenza virus cap-dependent endonuclease inhibitors

Journal of Virological Methods

Volumn 202, Issue , 2014, Pages 8-14

  Shibagaki, Yoshio ^a   Ikuta, Naoko ^a   Iguchi, Sachiko ^a   Takaki, Kyoko ^a   Watanabe, Shinji ^a   Kaihotsu, Masashi ^a   Masuda, Chiaki ^a   Maeyama, Kazuhiko ^a   Mizumoto, Kiyohisa ^a   Hattori, Seisuke ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Antiviral agent; Cap snatching; Influenza virus; MRNA capping

Indexed keywords

BIOTIN; ENDONUCLEASE; ENDONUCLEASE INHIBITOR; ESTERASE INHIBITOR; MESSENGER RNA; RECOMBINANT ENZYME; RNA POLYMERASE II; STREPTAVIDIN; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; ENZYME INHIBITOR; METHYLATED CAP-DEPENDENT ENDONUCLEASE; RIBONUCLEASE; VIRUS PROTEIN;

ARTICLE; ASSAY; BIOTINYLATION; CHEMICAL INTERACTION; COLUMN CHROMATOGRAPHY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENETIC TRANSCRIPTION; INFLUENZA VIRUS; INTERACTIONS WITH RNA; NONHUMAN; PRIORITY JOURNAL; RNA CAP SNATCHING; RNA CAPPING; RNA CLEAVAGE; RNA PURIFICATION; RNA STRUCTURE; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; EVALUATION STUDY; HUMAN; ISOLATION AND PURIFICATION; ORTHOMYXOVIRUS; PROCEDURES;

ANTIVIRAL AGENTS; DRUG EVALUATION, PRECLINICAL; ENDORIBONUCLEASES; ENZYME INHIBITORS; HUMANS; ORTHOMYXOVIRIDAE; VIRAL PROTEINS;

EID: 84896497550     PISSN: 01660934     EISSN: 18790984     Source Type: Journal    
DOI: 10.1016/j.jviromet.2014.02.005     Document Type: Article

References (41)

1. Banerjee A.K. 5'-Terminal cap structure in eucaryotic messenger ribonucleic acids. Microbiological Reviews 1980, 44:175-205.
2. Belanger F., Stepinski J., Darzynkiewicz E., Pelletier J. Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. Journal of Biological Chemistry 2010, 285:33037-33044.
3. Bouloy M., Plotch S.J., Krug R.M. Globin mRNAs are primers for the transcription of influenza viral RNA in vitro. Proceedings of the National Academy of Sciences of the United States of America 1978, 75:4886-4890.
4. Bouloy M., Plotch S.J., Krug R.M. Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcription. Proceedings of the National Academy of Sciences of the United States of America 1980, 77:3952-3956.
5. Bright R.A., Medina M.J., Xu X., Perez-Oronoz G., Wallis T.R., Davis X.M., Povinelli L., Cox N.J., Klimov A.I. Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 2005, 366:1175-1181.
6. Das K. Antivirals targeting influenza A virus. Journal of Medicinal Chemistry 2012, 55:6263-6277.
7. Das K., Aramini J.M., Ma L.C., Krug R.M., Arnold E. Structures of influenza A proteins and insights into antiviral drug targets. Nature Structural & Molecular Biology 2010, 17:530-538.
8. De Clercq E. Antiviral agents active against influenza A viruses. Nature Reviews. Drug Discovery 2006, 5:1015-1025.
9. Decroly E., Ferron F., Lescar J., Canard B. Conventional and unconventional mechanisms for capping viral mRNA. Nature Reviews Microbiology 2011, 10:51-65.
10. Furuichi Y., Shatkin A.J. Viral and cellular mRNA capping: past and prospects. Advances in Virus Research 2000, 55:135-184.
11. Hayden F.G., Belshe R.B., Clover R.D., Hay A.J., Oakes M.G., Soo W. Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. New England Journal of Medicine 1989, 321:1696-1702.
12. Horisberger M.A. The large P proteins of influenza A viruses are composed of one acidic and two basic polypeptides. Virology 1980, 107:302-305.
13. Hsu J.T., Yeh J.Y., Lin T.J., Li M.L., Wu M.S., Hsieh C.F., Chou Y.C., Tang W.F., Lau K.S., Hung H.C., Fang M.Y., Ko S., Hsieh H.P., Horng J.T. Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus. Antimicrobial Agents and Chemotherapy 2012, 56:647-657.
14. Klumpp K., Hooker L., Handa B. Influenza virus endoribonuclease. Methods in Enzymology 2001, 342:451-466.
15. Le Q.M., Kiso M., Someya K., Sakai Y.T., Nguyen T.H., Nguyen K.H., Pham N.D., Ngyen H.H., Yamada S., Muramoto Y., Horimoto T., Takada A., Goto H., Suzuki T., Suzuki Y., Kawaoka Y. Avian flu: isolation of drug-resistant H5N1 virus. Nature 2005, 437:1108.
16. Mao X., Schwer B., Shuman S. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Molecular and Cellular Biology 1995, 15:4167-4174.
17. McCracken S., Fong N., Rosonina E., Yankulov K., Brothers G., Siderovski D., Hessel A., Foster S., Shuman S., Bentley D.L. 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes & Development 1997, 11:3306-3318.
18. Milligan J.F., Uhlenbeck O.C. Synthesis of small RNAs using T7 RNA polymerase. Methods in Enzymology 1989, 180:51-62.
19. Mizumoto K., Kaziro Y. Messenger RNA capping enzymes from eukaryotic cells. Progress in Nucleic Acid Research and Molecular Biology 1987, 34:1-28.
20. Pei Y., Schwer B., Hausmann S., Shuman S. Characterization of Schizosaccharomyces pombe RNA triphosphatase. Nucleic Acids Research 2001, 29:387-396.
21. Plotch S.J., Bouloy M., Ulmanen I., Krug R.M. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 1981, 23:847-858.
22. Salomon R., Webster R.G. The influenza virus enigma. Cell 2009, 136:402-410.
23. Schnierle B.S., Gershon P.D., Moss B. Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:2897-2901.
24. Shibagaki Y., Holmes M.L., Appa R.S., Chow S.A. Characterization of feline immunodeficiency virus integrase and analysis of functional domains. Virology 1997, 230:1-10.
25. Shibagaki Y., Itoh N., Yamada H., Nagata S., Mizumoto K. mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae. Journal of Biological Chemistry 1992, 267:9521-9528.
26. Shuman S. Catalytic activity of vaccinia mRNA capping enzyme subunits coexpressed in Escherichia coli. Journal of Biological Chemistry 1990, 265:11960-11966.
27. Shuman S., Liu Y., Schwer B. Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:12046-12050.
28. Shuman S., Surks M., Furneaux H., Hurwitz J. Purification and characterization of a GTP-pyrophosphate exchange activity from vaccinia virions. Association of the GTP-pyrophosphate exchange activity with vaccinia mRNA guanylyltransferase. RNA (guanine-7-)methyltransferase complex (capping enzyme). Journal of Biological Chemistry 1980, 255:11588-11598.
29. Studier F.W., Rosenberg A.H., Dunn J.J., Dubendorff J.W. Use of T7 RNA polymerase to direct expression of cloned genes. Methods in Enzymology 1990, 185:60-89.
30. Takagi T., Moore C.R., Diehn F., Buratowski S. An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. Cell 1997, 89:867-873.
31. Tomassini J., Selnick H., Davies M.E., Armstrong M.E., Baldwin J., Bourgeois M., Hastings J., Hazuda D., Lewis J., McClements W., et al. Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrobial Agents and Chemotherapy 1994, 38:2827-2837.
32. Tomassini J.E., Davies M.E., Hastings J.C., Lingham R., Mojena M., Raghoobar S.L., Singh S.B., Tkacz J.S., Goetz M.A. A novel antiviral agent which inhibits the endonuclease of influenza viruses. Antimicrobial Agents and Chemotherapy 1996, 40:1189-1193.
33. Tsukamoto T., Shibagaki Y., Imajoh-Ohmi S., Murakoshi T., Suzuki M., Nakamura A., Gotoh H., Mizumoto K. Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. Biochemical and Biophysical Research Communications 1997, 239:116-122.
34. Tsukamoto T., Shibagaki Y., Murakoshi T., Suzuki M., Nakamura A., Gotoh H., Mizumoto K. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. Biochemical and Biophysical Research Communications 1998, 243:101-108.
35. Tsukamoto T., Shibagaki Y., Niikura Y., Mizumoto K. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Biochemical and Biophysical Research Communications 1998, 251:27-34.
36. Ulmanen I., Broni B.A., Krug R.M. Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proceedings of the National Academy of Sciences of the United States of America 1981, 78:7355-7359.
37. Wakai C., Iwama M., Mizumoto K., Nagata K. Recognition of cap structure by influenza B virus RNA polymerase is less dependent on the methyl residue than recognition by influenza A virus polymerase. Journal of Virology 2011, 85:7504-7512.
38. Werner M., Purta E., Kaminska K.H., Cymerman I.A., Campbell D.A., Mittra B., Zamudio J.R., Sturm N.R., Jaworski J., Bujnicki J.M. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Nucleic Acids Research 2011, 39:4756-4768.
39. Yamada-Okabe T., Doi R., Shimmi O., Arisawa M., Yamada-Okabe H. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Nucleic Acids Research 1998, 26:1700-1706.
40. Yamagishi M., Mizumoto K., Ishihama A. Isolation of temperature-sensitive mutants for mRNA capping enzyme in Saccharomyces cerevisiae. Molecular & General Genetics: MGG 1995, 249:147-154.
41. Yue Z., Maldonado E., Pillutla R., Cho H., Reinberg D., Shatkin A.J. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:12898-12903.