Mechanical properties of electrospun PCL scaffold under in vitro and accelerated degradation conditions

Biomedical Engineering - Applications, Basis and Communications

Volumn 26, Issue 3, 2014, Pages

  Løvdal, Alexandra ^a   Vange, Jakob ^b   Nielsen, Lene Feldskov ^b   Almdal, Kristoffer ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b Coloplast A/S ^*  (Denmark)

Author keywords

Electrospinning; Fibroblasts; In vitro; In vitro degradation; Mechanical properties; Polycaprolactone (PCL)

Indexed keywords

BIODEGRADATION; CELL CULTURE; ELECTROSPINNING; FIBROBLASTS; MECHANICAL PROPERTIES; MOLECULAR WEIGHT; PHYSIOLOGY; POLYCAPROLACTONE; SCAFFOLDS (BIOLOGY);

ACCELERATED DEGRADATION; BIODEGRADABLE SCAFFOLD; DEGRADATION TIME; ELECTROSPUNS; IN-VITRO; LINEAR DECREASE; NO REDUCTION; PHYSIOLOGICAL FLUIDS;

BIOMECHANICS;

POLYCAPROLACTONE; TISSUE SCAFFOLD;

ACCELERATION; ARTICLE; BIOMECHANICS; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DEGRADATION; ELECTROSPINNING; FIBROBLAST; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INCUBATION TIME; MOLECULAR WEIGHT; SCANNING ELECTRON MICROSCOPY; STRESS STRAIN RELATIONSHIP; STRETCHING; TENSILE STRENGTH; THICKNESS; YOUNG MODULUS;

EID: 84896485087     PISSN: 10162372     EISSN: None     Source Type: Journal    
DOI: 10.4015/S1016237214500434     Document Type: Article

References (35)

1. Vert M, Li SM, Spenlehauer G, Guerin P, Bioresorbability and biocompatibility of aliphatic polyesters, J Mater Sci Mater Med 3:432, 1992.
2. Lendlein A, Sisson A (eds.) Biodegradable Shape-Memory Polymers Handbook of Biodegradable Polymers, Weinheim, Germany, pp. 195-212, 2011.
3. Woodru MA, Hutmacher DW, The return of a forgotten polymer polycaprolactone in the 21st century, Prog Polym Sci 35:1217, 2010.
4. Kweon H, Yoo M, Paek I, Kim T, Lee H, Lee H, Oh J, Akaike T, Cho C, A novel degradable polycaprolactone networks for tissue engineering, Biomaterials 24:801, 2003.
5. Vieira AC, Vieira JC, Ferra JM, Magalhaes FD, Guedes RM, Marques AT, Mechanical study of PLA-PCL fibers during in vitro degradation, J Mech Behav Biomed 4:451, 2011.
6. Kai D, Prabhakaran P, Jin G, Ramakrisna S, Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering, J Biomed Mater Res, 98B:379, 2011.
7. Jeon H, Kim GH, E ect of the internal microstructure in rapid-prototyped polycaprolactone sca olds on physical and cellular properties for bone tissue regeneration, Appl Phys A 108:901, 2012.
8. Xiang P, Li M, Zhang C, Chen D, Zhou Z, Cytocompatibility of electrospun nanofiber tubular sca olds for small diameter tissue engineering blood vessels, Int J Biol Macromol 49:281, 2011.
9. Nair GT, Mony U, Chennazhi KP, Nair SV, In vitro evaluation of electrospun PCL/nanoclay composite scaffold for bone tissue engineering, J Mater Sci Mater Med 23:174, 2012.
10. Wang G, Chen G, Wei Z, Yu T, Liu L, Wang P, A comparative study of TiO2 and surface-Treated TiO2 nanoparticles on thermal and mechanical properties of Poly("-caprolactone) nanocomposites, J Appl Polym Sci 125:3871, 2012.
11. Yang S, Leong K, Du Z, Chua C, Review, the design of sca olds for use in tissue engineering, Part I. Traditional factors, Tissue Eng 7:679, 2011.
12. Croisier F, Duwez, A-S, J-erôme C, L-eonard AF, van der Werf KO, Dijkstra PJ, Bennink ML, Mechanical testing of electrospun PCL fibers, Acta Biomater 8:218, 2012.
13. Ratner BD, Ho man AS, Schoen FJ, Lemons JE (eds.) Biomaterials Science, Elsevier Academic Press, pp. 709-749, 2004.
14. Cui Z, Nelson B, Peng Y, Li K, Pilla S, Li W, Turng L, Shen C, Fabrication and characterization of injection molded poly ("-caprolactone) and poly ("-caprolactone)/hydroxyapatite sca olds for tissue engineering, Mater Sci Eng C 32:1674, 2012.
15. Lohfeld S, Cahill S, Barron V, McHugh P, DUrselen L, Kreja L, Bausewein C, Ignatius A, Fabrication, mechanical and in vivo performance of polycaprolactone/tricalcium phosphate composite sca olds, Acta Biomater 8:3446, 2012.
16. Vaquette C, Cooper-White JJ, Increasing electrospun sca old pore size with tailored collectors for improved cell penetration, Acta Biomater 7:2544, 2011.
17. B€olgen N, Menceloǧlu YZ, Acatay K, Vargel I, Pişkin E, In vitro and in vivo degradation of non-woven materials made of poly ("-caprolactone) nanofibers prepared by electrospinning under di erent conditions, J Biomater Sci Polym Edn 16:1537, 2005.
18. Seyednejad H, Ji W, Schuurman W, Dhert WJ, Malda J, Yang F, Jansen JA, Nostrum CV, Vermonden T, Hennink WE, An electrospun degradable sca old based on a novel hydrophilic polyester for tissue-engineering applications, Macromol Biosci 11:1684, 2011.
19. Lee KH, Kim HY, Khil MS, Ra YM, Lee DR, Characterization of nano-structured poly ("-caprolactone) nonwoven mats via electrospining, Polymer 44:1287, 2003.
20. Pham QP, Sharma U, Mikos AG, Electrospinning of polymeric nanofibers for tissue engineering applications: A review, Tissue Eng 12:1197, 2006.
21. Park S, Kim T, Kim H, Yang D, Park T, Development of dual scale sca olds via direct polymer melt deposition and electrospinning for applications in tissue regeneration, Acta Biomater 4:1198, 2008.
22. Coombes AGA, Rizzi SC, Williamson M, Barralet JE, Downes S, Wallace WA, Precipitation casting of polycaprolactone for applications in tissue engineering and drug delivery, Biomaterials 25:315, 2004.
23. Doustgani A, Vasheghani-Farahani E, Soleimani M, Hashemi-Najafabadi, Optimizing themechanical properties of electrospun polycaprolactone and nanohydroxyapatite composite nanofibers, Compos Part B: Eng 43:1830, 2012.
24. Kielberg V, BrUnner N, Briand P (eds.), Celledyrkning, Foreningen af Danske L-gestuderendes Forlag, 1994.
25. Johnson J, Niehaus A, Nichols S, Lee DJK, Anderson D, Lannutti J, Electrospun PCL in vitro: A microstructural basis for mechanical property changes, J Biomater Sci 20:467, 2009.
26. Lam CF, Hutmacher D, Schantz J, Woodru M, Teoh S, Evaluation of polycaprolactone sca old degradation, J Bio Mater Res Part A 90:906, 2008.
27. Vidaurre A, Meseguer-Dueñas JM, M-As-Estell-es J, Cortazar IC, Inuence of enzymatic degradation on physical properties of poly("- caprolactone) films and sponges, Macromol Symp 269:38, 2009.
28. Castilla-Cort-Azar I, M-As-Estell-es J, Meseguer-Dueñas JM, Escobar Ivirico JL, Marí B, Vidaurre A, Hydrolytic and enzymatic degradation of a poly ("-caprolactone) network, Polym Degrad Stabil 97:1241, 2012.
29. Huang Z, Zhang YZ, Ramakrishna A, Lim CT, Electrospinning and mechanical characterization of gelatinnano fibers, Polymer 45:5361, 2004.
30. McEachin E, Lozano K, Production and characterization of polycaprolactone nanofibers via forcespinning technology, J Appl Polym Sci 126:473, 2012.
31. Shah AA, Hasan F, Hameed A, Ahmed S, Biological degradation of plastics: A comprehensive review, Biotech Adv 26:246, 2008.
32. Temeno JS, Mikos AG, Injectable biodegradable materials for orthopedic tissue engineering, Biomaterials 21:2405, 2000.
33. Sun H, Mei L, Song C, Cui X, Wang P, The in vivo degradation, absorption and excretion of PCL-based implant, Biomaterials 27:1735, 2006.
34. Shakhssalim N, Dehghan MM, Moghadasali R, Soltani MH, Shabani I, Soleimani M, Bladder tissue engineering using biocompatible nanofibrous electrospun constructs, Urology J 9:410, 2012.
35. Samani A, Bishop J, Luginbuhl C, Plewes DB, Measuring the elastic modulus of ex vivo small tissue samples, Phys Med Biol 48:2183, 2003.