Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects

International Journal of Molecular Sciences

Volumn 15, Issue 3, 2014, Pages 3926-3951

  Shih, Hung Cheng ^a   Chern, Ching Yuh ^b   Kuo, Ping Chung ^c   Wu, You Cheng ^a   Chan, Yu Yi ^d   Liao, Yu Ren ^a   Teng, Che Ming ^e   Wu, Tian Shung ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c NATIONAL FORMOSA UNIVERSITY   (Taiwan)

^d SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anti platelet aggregation; Ginger; Gingerol; Shogaol; Zingiber officinale

Indexed keywords

(10) GINGEROL; (5) GINGEROL; (6) GINGEROL; (7) GINGEROL; (8) GINGEROL; (9) GINGEROL; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYDEC 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYDODEC 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYNON 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYTETRADEC 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYTRIDEC 1 EN 3 ONE; 1 (4 HYDROXY 3 METHOXYPHENYL) 4,5 EXPOXYUNDEC 1 EN 3 ONE; 10 DEHYDROGINGEROL; 10 DEHYDROPARADOL; 10 DEHYDROSHOGAOL; 10 PARADOL; 5 DEHYDROGINGEROL; 5 DEHYDROPARADOL; 5 DEHYDROSHOGAOL; 5 ISODEHYDROGINGERDIONE; 5 PARADOL; 6 DEHYDROGINGEROL; 6 DEHYDROPARADOL; 6 DEHYDROSHOGAOL; 6 ISODEHYDROGINGERDIONE; 6 PARADOL; 7 DEHYDROGINGEROL; 7 DEHYDROPARADOL; 7 DEHYDROSHOGAOL; 7 ISODEHYDROGINGERDIONE; 7 PARADOL; 8 DEHYDROGINGEROL; 8 DEHYDROPARADOL; 8 DEHYDROSHOGAOL; 8 PARADOL; 9 DEHYDROGINGEROL; 9 DEHYDROPARADOL; 9 DEHYDROSHOGAOL; 9 ISODEHYDROGINGERDIONE; 9 PARADOL; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; COLLAGEN; DEHYDROZINGERONE; DRUG ANALOG; GINGEROL; PARADOL; SHOGAOL; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; CATECHOL DERIVATIVE; FATTY ALCOHOL; PLANT EXTRACT;

ANIMAL CELL; ARTICLE; CATALYST; CELL COUNTER; CHLORINATION; CIRCULATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; GINGER; HEMOSTASIS; HYDROGENATION; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLATELET AGGREGATION ASSAY; RABBIT; RHIZOME; SWERN OXIDATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE COUNT; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; OXIDATION REDUCTION REACTION; SYNTHESIS; THROMBOCYTE AGGREGATION;

ANIMALS; CATECHOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FATTY ALCOHOLS; GINGER; HYDROGENATION; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; RABBITS; RHIZOME;

EID: 84896472832     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15033926     Document Type: Article

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