GM-CSF induces cyclin D1 expression and proliferation of endothelial progenitor cells via PI3K and MAPK signaling

Cellular Physiology and Biochemistry

Volumn 33, Issue 3, 2014, Pages 784-795

  Qiu, Chaolin ^a   Xie, Qiuhua ^a   Zhang, Dongqing ^b   Chen, Qing ^a   Hu, Jinhui ^a   Xu, Limin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cell cycle; Endothelial progenitor cells; Granulocyte macrophage colony stimulating factor; Proliferation; Signaling pathways

Indexed keywords

CYCLIN D1; CYCLIN E; GLYCOGEN SYNTHASE KINASE 3; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; STAT PROTEIN; TRANSCRIPTION FACTOR E2F1; CCND1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3BETA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL CULTURE; CELL CYCLE PROGRESSION; CELL ISOLATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL; CELL CYCLE; MTT ASSAY; PROTEIN ANALYSIS; WESTERN BLOTTING;

CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; STEM CELLS;

EID: 84896431374     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358652     Document Type: Article

References (30)

1. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.
2. Navarro-Sobrino M, Hernandez-Guillamon M, Fernandez-Cadenas I, Ribo M, Romero IA, Couraud PO, Weksler BB, Montaner J, Rosell A: The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients. Vase Cell 2013;5:3.
3. Rafii S, Lyden D: Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003;9:702-712.
4. George AL, Bangalore-Prakash P, Rajoria S, Suriano R, Shanmugam A, Mittelman A, Tiwari RK: Endothelial progenitor cell biology in disease and tissue regeneration. J Hematol Oncol 2011;4:24.
5. Metcalf D: The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 1989;339:27-30.
6. Gasson JC: Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood 1991;77:1131-1145.
7. Valdembri D, Serini G, Vacca A, Ribatti D, Bussolino F: In vivo activation of jak2/stat-3 pathway during angiogenesis induced by gm-csf. FASEB J 2002;16:225-227.
8. Bussolino F, Wang JM, Defilippi P, Turrini F, Sanavio F, Edgell CJ, Aglietta M, Arese P, Mantovani A: Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 1989;337:471-473.
9. Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T: Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999;5:434-438.
10. Seiler C, Pohl T, Wustmann K, Hutter D, Nicolet PA, Windecker S, Eberli FR, Meier B: Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: A randomized, double-blind, placebo-controlled study. Circulation 2001;104:2012-2017.
11. Wang QR, Wang F, Zhu WB, Lei J, Huang YH, Wang BH, Yan Q: Gm-csf accelerates proliferation of endothelial progenitor cells from murine bone marrow mononuclear cells in vitro. Cytokine 2009;45:174-178.
12. Coffer PJ, Schweizer RC, Dubois GR, Maikoe T, Lammers JW, Koenderman L: Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the t-helper 2-derived cytokines interleukin-4 and interleukin-5. Blood 1998;91:2547-2557.
13. Wheadon H, Roberts PJ, Watts MJ, Linch DC: Changes in signal transduction downstream from the granulocyte-macrophage colony-stimulating factor receptor during differentiation of primary hemopoietic cells. Exp Hematol 1999;27:1077-1086.
14. Kolonics A, Apati A, Janossy J, Brozik A, Gati R, Schaefer A, Magocsi M: Activation of raf/erkl/2 map kinase pathway is involved in gm-csf-induced proliferation and survival but not in erythropoietin-induced differentiation of tf-1 cells. Cell Signal 2001;13:743-754.
15. Schallenberg M, Charalambous P, Thanos S: Gm-csf regulates the erkl/2 pathways and protects injured retinal ganglion cells from induced death. Exp Eye Res 2009;89:665-677.
16. Por E, Byun HJ, Lee EJ, Lim JH, Jung SY, Park I, Kim YM, Jeoung DI, Lee H: The cancer/testis antigen cage with oncogenic potential stimulates cell proliferation by up-regulating cyclins dl and e in an ap-1-and e2f-dependent manner. J Biol Chem 2010;285:14475-14485.
17. Soldi R, Primo L, Brizzi MF, Sanavio F, Aglietta M, Polentarutti N, Pegoraro L, Mantovani A, Bussolino F: Activation of jak2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor. Blood 1997;89:863-872.
18. Mieno S, Boodhwani M, Robich MP, Clements RT, Sodha NR, Sellke FW: Effects of diabetes mellitus on vegf-induced proliferation response in bone marrow derived endothelial progenitor cells. J Card Surg 2010;25:618-625.
19. Takahashi-Yanaga F, Sasaguri T: Gsk-3beta regulates cyclin dl expression: A new target for chemotherapy. Cell Signal 2008;20:581-589.
20. Karin M: The regulation of ap-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-16486.
21. Shaulian E, Karin M: Ap-1 in cell proliferation and survival. Oncogene 2001;20:2390-2400.
22. Colotta F, Bussolino F, Polentarutti N, Guglielmetti A, Sironi M, Bocchietto E, De Rossi M, Mantovani A: Differential expression of the common beta and specific alpha chains of the receptors for gm-csf, il-3, and il-5 in endothelial cells. Exp Cell Res 1993;206:311-317.
23. Corey S, Eguinoa A, Puyana-Theall K, Bolen JB, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3oh-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 1993;12:2681-2690.
24. Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN: Jak2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 1994;14:4335-4341.
25. Zhao W, Yang X-H: Pi3k-dependent erk is involved in gm-csf-mediated activation of progenitor cells in a neovascularisation model. South African Journal of Science 2010;106:69-77.
26. Caldon CE, Sutherland RL, Musgrove E: Cell cycle proteins in epithelial cell differentiation: Implications for breast cancer. Cell Cycle 2010;9:1918-1928.
27. Musgrove EA: Cyclins: Roles in mitogenic signaling and oncogenic transformation. Growth Factors 2006;24:13-19.
28. Herber B, Truss M, Beato M, Muller R: Inducible regulatory elements in the human cyclin dl promoter. Oncogene 1994;9:1295-1304.
29. Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG: Transforming p21ras mutants and c-ets-2 activate the cyclin dl promoter through distinguishable regions. J Biol Chem 1995;270:23589-23597.
30. JinYJ, Lee JH, Kim YM, Oh GT, Lee H: Macrophage inhibitory cytokine-1 stimulates proliferation ofhuman umbilical vein endothelial cells by up-regulating cyclins dl and e through the pi3k/akt-, erk-, and jnk-dependent ap-1 and e2f activation signaling pathways. Cell Signal 2012;24:1485-1495.