Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation

Brain Stimulation

Volumn 7, Issue 2, 2014, Pages 252-259

  Jay, Emma Louise ^a   Sierra, Mauricio ^a   Van Den Eynde, Frederique ^b   Rothwell, John C ^c   David, Anthony S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

Author keywords

Depersonalization disorder; Neuronavigation guided TMS; Prefrontal cortex; Repetitive transcranial magnetic stimulation; Skin conductance responses; Temporal parietal cortex

Indexed keywords

ADULT; AROUSAL; ARTICLE; CAMBRIDGE DEPERSONALIZATION SCALE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPERSONALIZATION; DSM-IV; ELECTRODERMAL RESPONSE; EMOTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INSULA; MALE; NEUROBIOLOGY; NEUROMODULATION; NEURONAVIGATION; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTCOME ASSESSMENT; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SKIN CONDUCTANCE; TEMPOROPARIETAL JUNCTION; TRANSCRANIAL MAGNETIC STIMULATION; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AROUSAL; DEPERSONALIZATION; EMOTIONS; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURONAVIGATION; PREFRONTAL CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84896403040     PISSN: 1935861X     EISSN: 18764754     Source Type: Journal    
DOI: 10.1016/j.brs.2013.12.002     Document Type: Article

References (66)

1. M. Sierra The symptoms of depersonalization Depersonalization: a new look at a neglected syndrome 2009 Cambridge University Press Cambridge 24 43.
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders 4th ed. 1994 American Psychiatric Press Washington, DC.
3. M. Sierra, J. Gomez, J.J. Molina, R. Luque, J.F. Muñoz, and A.S. David Depersonalization in psychiatric patients: a transcultural study J Nerv Ment Dis 194 2006 356 361.
4. E.C.M. Hunter, M. Sierra, and A.S. David The epidemiology of depersonalization and derealisation: a systematic review Soc Psychiatry Psychiatr Epidemiol 9 2004 9 18.
5. D. Baker, E. Hunter, E. Lawrence, N. Medford, M. Patel, and C. Senior et al. Depersonalisation disorder: clinical features of 204 cases Br J Psychiatry 182 2003 428 433.
6. D. Simeon, M. Knutelska, D. Nelson, and O. Guralnik Feeling unreal: a depersonalization disorder update of 117 cases J Clin Psychiatry 64 2003 990 997.
7. G. Sedman Depersonalization in a group of normal subjects Br J Psychiatry 112 1966 907 912.
8. M. Sierra, N. Medford, G. Wyatt, and A.S. David Depersonalisation disorder and anxiety: a special relationship? Psychiatry Res 197 2012 123 127.
9. M.V. Lambert, M. Sierra, M.L. Phillips, and A.S. David The spectrum of organic depersonalization: a review plus four new cases J Neuropsychiatry Clin Neurosci 14 2002 141 154.
10. N. Medford, D. Baker, E. Hunter, M. Sierra, E. Lawrence, and M.L. Phillips et al. Chronic depersonalization following illicit drug use: a controlled analysis of 40 cases Addiction 98 2003 1731 1736.
11. D. Simeon, D. Kozin, K. Segal, and B. Lerch Is depersonalization disorder initiated by drug use any different? A survey of 394 adults J Clin Psychiatry 70 2009 1358 1364.
12. M. Sierra Towards a pharmacology of depersonalization Depersonalization: a new look at a neglected syndrome 2009 Cambridge University Press Cambridge 113 123.
13. M. Sierra, M.L. Phillips, G. Irvin, J. Krystal, and A.S. David A placebo-controlled cross-over trial of lamotrigine in depersonalization disorder J Psychopharmacol 17 2003 103 105.
14. E.C. Hunter, M.L. Phillips, T. Chalder, M. Sierra, and A.S. David Depersonalisation disorder: a cognitive-behavioural conceptualization Behav Res Ther 41 2003 1451 1467.
15. E.C. Hunter, D. Baker, M.L. Phillips, M. Sierra, and A.S. David Cognitive-behaviour therapy for depersonalisation disorder: an open study Behav Res Ther 43 2005 1121 1130.
16. M. Sierra, and G.E. Berrios Depersonalization: neurobiological perspectives Biol Psychiatry 44 1998 898 908.
17. M. Sierra, F. Lopera, M.V. Lambert, M.L. Phillips, and A.S. David Separating depersonalization and derealisation: the relevance of the "lesion method" J Neurol, Neurosurg Psychiatry 72 2002 530 532.
18. M.L. Phillips, N. Medford, C. Senior, E.T. Bullmore, J. Suckling, and M.J. Brammer et al. Depersonalization disorder: thinking without feeling Psychiatry Res 108 2001 145 160.
19. N. Medford, B. Brierley, M. Brammer, E.T. Bullmore, A.S. David, and M.L. Phillips Emotional memory in depersonalization disorder: a functional MRI study Psychiatry Res 148 2006 93 102.
20. M.H. Lader, and L. Wing Physiological measures, sedative drugs, and morbid anxiety Maudsley Mongraphs No. 14 1966 Oxford University Press London 179.
21. M. Sierra, C. Senior, J. Dalton, M. McDonough, A. Bond, and M.L. Phillips et al. Autonomic response in depersonalization disorder Arch Gen Psychiatry 59 2002 833 838.
22. E. Lemche, S.A. Surgaladze, V.P. Giampetro, A. Anilkumar, M.J. Brammer, and M. Sierra et al. Limbic and prefrontal responses to emotion face expressions in depersonalization Neuroreport 18 2007 473 477.
23. E. Lemche, A. Anilkumar, V.P. Giampetro, S. Surguladze, D. Gasston, and X. Chitnis et al. Cerebral and autonomic responses to emotional facial expressions in depersonalization disorder Br J Psychiatry 193 2008 222 228.
24. G. Tabibnia, A.B. Satpute, and M.D. Liberman The sunny side of fairness: preference for fairness activates reward circuitry (and disregarding unfairness activates self-control circuitry) Psychol Sci 19 2008 339 347.
25. S.J. Bishop Trait anxiety and impoverished prefrontal control of attention Nat Neurosci 12 1 2009 92 98.
26. N. Medford Emotional and the unreal self: depersonalization disorder and de-affectualisation Emotion Rev 4 2 2012 139 144.
27. M. Sierra, M.L. Phillips, M.V. Lambert, C. Senior, A.S. David, and J.H. Krystal Lamotrigine in the treatment of depersonalization disorder J Clin Psychiatry 62 2001 826 827.
28. M. Sierra-Siegert, and A.S. David Depersonalization: a selective impairment of self-awareness Conscious Cogn 20 1 2011 99 108.
29. M. Hallett Transcranial magnetic stimulation Nature 406 2000 147 150.
30. L. Leyman, R. De Raedt, M.A. Vanderhasselt, and C. Baecken Influence of high-frequency repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex on the inhibition of emotional information in healthy volunteers Psychol Med 39 2009 1019 1028.
31. D. Knoch, L.R. Gianotti, A. Pascual-Leone, V. Treyer, M. Regards, and M. Hohmann et al. Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behaviour J Neurosci 26 2006 6469 6472.
32. D. Knoch, A. Pascual-Leone, K. Meyer, V. Treyer, and E. Fehr Diminishing reciprocal fairness by disrupting the right prefrontal cortex Science 314 2006 829 832.
33. M. Van't Wout, R.S. Kahn, A.G. Sanfrey, and A. Aleman Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex affects strategic decision-making Neuroreport 16 2005 1849 1852.
34. R. Uher, D. Yoganathan, A. Mogg, S.V. Eranti, J. Treasure, and I.C. Campbell et al. Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving Biol Psychiatry 58 2005 840 842.
35. P. Eichhammer, M. Johann, A. Kharraz, H. Binder, D. Pittrow, and N. Wodarz et al. High frequency repetitive transcranial magnetic stimulation decreases cigarette smoking J Clin Psychiatry 64 2003 951 953.
36. J.A. Camprodon, J. Martinez-Raga, M. Alonso-Alonso, M.C. Shih, and A. Pascual-Leone One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving Drug Alcohol Depend 86 2007 91 94.
37. J.P. Keenan, S. Freund, and A. Pascual-Leone Repetitive transcranial magnetic stimulation and depersonalization disorder. A case study Proc Abstr East Psychol Assoc 70 1999 78.
38. A.M. Jiménez-Genchi Repetitive transcranial magnetic stimulation improves depersonalization: a case report CNS Spectr 9 2004 375 376.
39. A. Mantovani, D. Simeon, N. Urban, P. Bulow, A. Allart, and S. Lisanby Temporo-parietal junction stimulation in the treatment of depersonalization disorder Psychiatry Res 186 1 2011 138 140.
40. O. Blanke, C. Mohr, C.M. Michel, A. Pascual-Leone, P. Brugger, and M. Seeck et al. Linking out-of-body experience and self processing to mental own-body imagery at the temporoparietal junction J Neurosci 25 2005 550 557.
41. O. Blanke, S. Ortigue, T. Landis, and M. Seeck Inducing illusory own-body perceptions Nature 419 2002 269 270.
42. K.N. Ochsner, and J.J. Gross The cognitive control of emotion Trends Cogn Sci 9 2005 242 249.
43. M. Sierra, and G.E. Berrios The Cambridge Depersonalisation Scale: a new instrument for the assessment of depersonalization Psychiatry Res 93 2000 153 164.
44. S. Rossi, M. Hallett, P.M. Rossini, A. Pascual-Leone Safety of TMS Consensus Group Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research J Clin Neurophysiol 120 2009 2008 2039.
45. A.T. Beck, C.H. Ward, M. Mendelson, J. Mock, and J. Erbaugh An inventory for measuring depression Arch Gen Psychiatry 4 1961 561 571.
46. A.T. Beck, N. Epstein, G. Brown, and R.A. Steer An inventory for measuring clinical anxiety: psychometric properties J Consult Clin Psychol 56 1988 893 897.
47. E. Bernstein, and F. Putnam Development, reliability, and validity of a dissociation scale J Nerv Ment Dis 174 1986 727 735.
48. C. Kerr, A. Robinson, A. Stevens, D. Braunholtz, S. Edwards, and R. Lilford Randomisation in trials: do potential trial participants understand it and find it acceptable? J Med Ethics 30 2004 8 84.
49. U. Herwig, F. Padberg, J. Unger, M. Spitzer, and C. Schönfeldt- Lecuona Transcranial magnetic stimulation in therapy studies: examination of the reliability of "standard" coil positioning by neuronavigation Biol Psychiatry 50 2001 58 61.
50. M.E. Dawson, A.M. Schell, and D.L. Filion The electrodermal system J.T. Cacioppo, L.G. Tassinary, G.G. Berntson, Handbook of psychophysiology 2nd ed 2000 Cambridge University Press Cambridge 200 223.
51. P.J. Lang, M.M. Bradley, and B.N. Cuthbert International Affective Picture System (IAPS): affective ratings of pictures and instruction manual 1999 Center for Research in Psychophysiology Gainesville, FL University of Florida.
52. M.M. Bradley, and P.J. Lang Affective norms for english words (ANEW): Stimuli, instruction manual and affective ratings: Technical report C-1 1999 Center for Research in Psychophysiology Gainesville, FL University of Florida.
53. Brain Sight 2. Neuronavigation System for TMS. www.rogue-research.com.
54. G.A. Miller, and J.P. Chapman Misunderstanding analysis of covariance J Abnorm Psychol 110 2001 40 48.
55. M. Tsakiris, M. Constantini, and P. Haggard The role of the right temporo-parietal junction in maintaining a coherent sense of one's body Neuropsychologia 46 2008 3014 3018.
56. J. van Honk, D.J. Schutter, A. d'Alfonso, R.P. Kessels, A. Postma, and E.H. de Haan Repetitive transcranial magnetic stimulation at the frontopolar cortex reduces skin conductance but not heart rate: reduced ray matter excitability in orbitofrontal regions Arch Gen Psychiatry 58 2001 973 974.
57. M. Christopeit, D. Simeon, N. Urban, J. Gowatsky, S.H. Lisanby, and A. Mantovani Effects of repetitive transcranial magnetic stimulation (rTMS) on specific symptom clusters in depersonalization disorder (DPD) Brain Stimul 2013 10.1016/j.brs.2013.07.006 pii: S1935-861X(13)00228-3.
58. M. Corbetta, and G.L. Shulman Control of goal-directed and stimulus-driven attention in the brain Nat Rev Neurosci 3 2002 201 215.
59. R. Saxe Uniquely human social cognition Curr Opin Neurobiol 16 2006 235 239.
60. D. Simeon, O. Guralnik, J. Schmeidler, and M. Knutelska Fluoxetine therapy in depersonalization disorder: randomized controlled trial Br J Psychiatry 185 2004 31 36.
61. S. Vanneste, and D. De Ridder The involvement of the left ventrolateral prefrontal cortex in tinnitus: a TMS study Exp Brain Res 221 2012 345 350.
62. S.F. Taylor, and Liberzon Neural correlates of emotion regulation in psychopathology Trends Cogn Sci 11 2007 413 418.
63. P.H. Chiu, A.J. Holmes, and D.A. Pizzagalli Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotion response inhibition Neuroimage 42 2008 988 997.
64. C. Eisenegger, V. Treyer, E. Fehr, and D. Knoch Time-course of "off-line" prefrontal rTMS effects - a PET study Neuroimage 42 2008 379 384.
65. E. Rounis, S.E. Klaas, L. Lee, H.R. Siebner, A. Presenti, and K.J. Friston et al. Acute changes in fronto-parietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task J Neurosci 26 2006 9629 9638.
66. H.J. Broadbent, F. van den Eynde, S. Guillaume, E.L. Hanif, D. Stahl, and A.S. David et al. Blinding success of rTMS applied to the dorsolateral prefrontal cortex in randomized sham-controlled trials: a systematic review World J Biol Psychiatry 12 2011 240 248