Lysosomal integral membrane protein 2 (LIMP-2) restricts the invasion of Trypanosoma cruzi extracellular amastigotes through the activity of the lysosomal enzyme β-glucocerebrosidase

Microbes and Infection

Volumn 16, Issue 3, 2014, Pages 253-260

  Gonçalves, Viviane Martinelli ^a   D'Almeida, Vânia ^a   Müller, Karen Barbosa ^a   Real, Fernando ^a   Mortara, Renato Arruda ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Extracellular amastigotes; LIMP 2; Trypanosoma cruzi; Glucocerebrosidase

Indexed keywords

BETA GLUCOCEREBROSIDASE; CERAMIDE; GLUCOSYLCERAMIDE; GLYCOSPHINGOLIPID; LYSOSOMAL INTEGRAL MEMBRANE PROTEIN 2; LYSOSOME ENZYME; PROTEIN; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CELL INVASION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GOLGI COMPLEX; HOST CELL; INFECTION; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; PROTOZOON; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA CRUZI;

EXTRACELLULAR AMASTIGOTES; LIMP-2; TRYPANOSOMA CRUZI; Β-GLUCOCEREBROSIDASE;

ANIMALS; ANTIGENS, CD36; CELL LINE; FIBROBLASTS; GLUCOSYLCERAMIDASE; LIFE CYCLE STAGES; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; TRYPANOSOMA CRUZI;

EID: 84896402255     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2013.11.004     Document Type: Article

References (24)

1. Tabuchi N., Akasaki K., Tsuji H. Two acidic amino acid residues, Asp(470) and Glu(471), contained in the carboxyl cytoplasmic tail of a major lysosomal membrane protein, LGP85/LIMP II, are important for its accumulation in secondary lysosomes. Biochem. Biophys. Res. Commun. 2000, 270:557-563.
2. Gamp A.C., Tanaka Y., Lullmann-Rauch R., Wittke D., D'Hooge R., De Deyn P.P., Moser T., Maier H., Hartmann D., Reiss K., Illert A.L., von Figura K., Saftig P. LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum. Mol. Genet. 2003, 12:631-646.
3. Kuronita T., Hatano T., Furuyama A., Hirota Y., Masuyama N., Saftig P., Himeno M., Fujita H., Tanaka Y. The NH(2)-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes. Traffic 2005, 6:895-906.
4. Reczek D., Schwake M., Schroder J., Hughes H., Blanz J., Jin X., Brondyk W., Van Patten S., Edmunds T., Saftig P. LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Cell 2007, 131:770-783.
5. Zimran A., Gelbart T., Westwood B., Grabowski G.A., Beutler E. High frequency of the Gaucher disease mutation at nucleotide 1226 among Ashkenazi Jews. Am. J. Hum. Genet. 1991, 49:855-859.
6. Balreira A., Gaspar P., Caiola D., Chaves J., Beirao I., Lima J.L., Azevedo J.E., Miranda M.C. A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. Hum. Mol. Genet. 2008, 17:2238-2243.
7. Barton N.W., Brady R.O., Dambrosia J.M., Di Bisceglie A.M., Doppelt S.H., Hill S.C., Mankin H.J., Murray G.J., Parker R.I., Argoff C.E., et al. Replacement therapy for inherited enzyme deficiency-macrophage-targeted glucocerebrosidase for Gaucher's disease. N. Engl. J. Med. 1991, 324:1464-1470.
8. Eskelinen E.L., Schmidt C.K., Neu S., Willenborg M., Fuertes G., Salvador N., Tanaka Y., Lullmann-Rauch R., Hartmann D., Heeren J., von Figura K., Knecht E., Saftig P. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol. Biol. Cell 2004, 15:3132-3145.
9. Binker M.G., Cosen-Binker L.I., Terebiznik M.R., Mallo G.V., McCaw S.E., Eskelinen E.L., Willenborg M., Brumell J.H., Saftig P., Grinstein S., Gray-Owen S.D. Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2. Cell Microbiol. 2007, 9:2153-2166.
10. Hissa B., Duarte J.G., Kelles L.F., Santos F.P., del Puerto H.L., Gazzinelli-Guimaraes P.H., de Paula A.M., Agero U., Mesquita O.N., Guatimosim C., Chiari E., Andrade L.O. Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells. PLoS Neglected Trop. Dis. 2012, 6:e1583.
11. Burleigh B.A., Andrews N.W. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu. Rev. Microbiol. 1995, 49:175-200.
12. Fernandes M.C., Cortez M., Geraldo Yoneyama K.A., Straus A.H., Yoshida N., Mortara R.A. Novel strategy in Trypanosoma cruzi cell invasion: implication of cholesterol and host cell microdomains. Int. J. Parasitol. 2007, 37:1431-1441.
13. Andrade L.O., Andrews N.W. Lysosomal fusion is essential for the retention of Trypanosoma cruzi inside host cells. J. Exp. Med. 2004, 200:1135-1143.
14. Fernandes M.C., Flannery A.R., Andrews N., Mortara R.A. Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells. Cell Microbiol. 2013, 15(6):977-991.
15. Yoshida N. Surface antigens of metacyclic trypomastigotes of Trypanosoma cruzi. Infect. Immun. 1983, 40:836-839.
16. Ley V., Andrews N.W., Robbins E.S., Nussenzweig V. Amastigotes of Trypanosoma cruzi sustain an infective cycle in mammalian cells. J. Exp. Med. 1988, 168:649-659.
17. Mortara R.A. Trypanosoma cruzi: amastigotes and trypomastigotes interact with different structures on the surface of HeLa cells. Exp. Parasitol. 1991, 73:1-14.
18. Fernandes M.C., Cortez M., Flannery A.R., Tam C., Mortara R.A., Andrews N.W. Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. J. Exp. Med. 2011, 208:909-921.
19. Raghavan S.S., Topol J., Kolodny E.H. Leukocyte beta-glucosidase in homozygotes and heterozygotes for Gaucher disease. Am. J. Hum. Genet. 1980, 32:158-173.
20. Weinreb N.J., Goldblatt J., Villalobos J., Charrow J., Cole J.A., Kerstenetzky M., Vom Dahl S., Hollak C. Long-term clinical outcomes in type 1 Gaucher disease following 10 years of imiglucerase treatment. J. Inherit. Metab. Dis. 2013, 36(3):543-553.
21. Piepenhagen P.A., Vanpatten S., Hughes H., Waire J., Murray J., Andrews L., Edmunds T., O'Callaghan M., Thurberg B.L. Use of direct fluorescence labeling and confocal microscopy to determine the biodistribution of two protein therapeutics, Cerezyme and Ceredase. Microsc. Res. Tech. 2010, 73:694-703.
22. Batista E.C., Carvalho L.R., Casarini D.E., Carmona A.K., dos Santos E.L., da Silva E.D., dos Santos R.A., Nakaie C.R., Rojas M.V., de Oliveira S.M., Bader M., D'Almeida V., Martins A.M., de Picoly Souza K., Pesquero J.B. ACE activity is modulated by the enzyme alpha-galactosidase A. J. Mol. Med. 2011, 89:65-74.
23. Sung S.S., Nelson R.S., Silverstein S.C. Yeast mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages. J. Cell Biol. 1983, 96:160-166.
24. Procópio D.O., Barros H.C., Mortara R.A. Actin-rich structures formed during the invasion of cultured cells by infective forms of Trypanosoma cruzi. Eur. J. Cell Biol. 1999, 78:911-924.