Use of direct fluorescence labeling and confocal microscopy to determine the biodistribution of two protein therapeutics, Cerezyme® and Ceredase®

Microscopy Research and Technique

Volumn 73, Issue 7, 2010, Pages 694-703

  Piepenhagen, Peter A ^a   Vanpatten, Scott ^a   Hughes, Heather ^a   Waire, James ^a   Murray, James ^a   Andrews, Laura ^a   Edmunds, Tim ^a   O'Callaghan, Michael ^a   Thurberg, Beth L ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Biodistribution; Confocal; Microscopy; Morphometry; Protein

Indexed keywords

ANIMALS; CELLS; CONFOCAL MICROSCOPY; CYTOLOGY; FLUORESCENCE; TISSUE;

BIODISTRIBUTIONS; CELL TYPES; CONFOCAL; FLUORESCENCE LABELLING; MORPHOMETRY; PRECLINICAL DEVELOPMENT; PROTEIN THERAPEUTICS; SIDE EFFECT; THERAPEUTIC EFFICACY; TISSUE TYPES;

PROTEINS;

ANIMALIA;

ALGLUCERASE; GLUCOSYLCERAMIDASE; IMIGLUCERASE;

ANIMAL; ANIMAL STRUCTURES; C57BL MOUSE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; ENZYME REPLACEMENT; FLUORESCENCE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; PROCEDURES; STAINING;

ANIMAL STRUCTURES; ANIMALS; ENZYME REPLACEMENT THERAPY; FLUORESCENCE; GLUCOSYLCERAMIDASE; INJECTIONS, INTRAVENOUS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; STAINING AND LABELING;

EID: 77954881189     PISSN: 1059910X     EISSN: 10970029     Source Type: Journal    
DOI: 10.1002/jemt.20810     Document Type: Article

References (16)

1. Berman M, Xie Y, Muller W. 1996. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta-2 integrin activation. J Immunol 156:1515-1524.
2. Beutler E. 1992. Gaucher disease: New molecular approaches to diagnosis and treatment. Science 256:794-799.
3. Bijsterbosch MK, Donker W, van de Bilt H, van Weely S, van Berkel TJ, Aerts JM. 1996. Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver endothelial cells. Eur J Biochem 237:344-349.
4. Friedman B, Vaddi K, Preston C, Mahon E, Cataldo JR, McPherson JM. 1999. A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: Implications for clinical efficacy in treatment of Gaucher disease. Blood 93:2807-2816.
5. Gotsch U, Borges E, Bosse R, Boggemeyer E, Simon M, Mossmann H, Vestweber D. 1997. VE-cadherin antibody accelerates neutrophil recruitment in vivo. J Cell Sci 110:583-588.
6. Grabowski G, Gatt S, Horowitz M. 1990. Acid beta-glucosidase: Enzymology and molecular biology of Gaucher disease. Crit Rev Biochem Mol Biol 25:385-414.
7. Grabowski GA, Barton NW, Pastores G, Dambrosia JM, Banerjee TK, McKee MA, Parker C, Schiffmann R, Hill SC, Brady RO. 1995. Enzyme therapy in type 1 Gaucher disease: Comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources. Ann Intern Med 122:33-39.
8. Jmoudiak M, Futerman AH. 2005. Gaucher disease: Pathological mechanisms and modern management. Br J Haematol 129:178-188.
9. Kingma W. 1996. Gaucher disease: An overview of clinical characteristics and therapy. J Intraven Nurs 19:79-82.
10. Lampugnani M, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco L, Dejana E. 1992. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J. Cell Biol 118:1511-1522.
11. Malorny U, Michels E, Sorg C. 1986. A monoclonal antibody against an antigen present on mouse macrophages and absent from monocytes. Cell Tissue Res 243:421-428.
12. McKnight AJ, Macfarlane AJ, Dri P, Turley L, Willis AC, Gordon S. 1996. Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem 271:486-489.
13. Murray GJ, Jin FS. 1995. Immunoelectron microscopic localization of mannose-terminal glucocerebrosidase in lysosomes of rat liver Kupffer cells. J Histochem Cytochem 43:149-158.
14. Murray GJ, Oliver KL, Jin FS, Brady RO. 1995. Studies on the turnover of exogenous mannose-terminal glucocerebrosidase in rat liver lysosomes. J Cell Biochem 57:208-217.
15. Sato Y, Beutler E. 1993. Binding, internalization, and degradation of mannose-terminated glucocerebrosidase by macrophages. J Clin Invest 91:1909-1917.
16. Zhu Y, Li X, Schuchman EH, Desnick RJ, Cheng SH. 2004. Dexamethasone-mediated up-regulation of the mannose receptor improves the delivery of recombinant glucocerebrosidase to Gaucher macrophages. J Pharmacol Exp Ther 308:705-711.