5,6-De-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from Withania somnifera L. Dunal leaves

Natural Product Research

Volumn 28, Issue 6, 2014, Pages 392-398

  Siddique, Amreen A ^a   Joshi, Pallavi ^a   Misra, Laxminarain ^a   Sangwan, Neelam S ^a   Darokar, Mahendra P ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

5,6 de epoxy 5 en 7 one 17 hydroxy withaferin A; cytotoxicity; Withania somnifera; withasteroids

Indexed keywords

16 EN 27 DEOXY WITHAFERIN A; 16BETA ACETOXY 6ALPHA ,7ALPHA EPOXY 5ALPHA HYDROXY 1 OXOWITHA 2,17(20),24 TRIENOLIDE; 27 DEOXY WITHAFERIN A; 27 HYDROXY WITHANONE; 5,6 DE EPOXY 5 EN 7 ONE 17 HYDROXY WITHAFERIN A; CYTOTOXIC AGENT; UNCLASSIFIED DRUG; WITHAFERIN A; WITHANOLIDE; WITHANOLIDE D; WITHANONE;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN CACO 2; CELL STRAIN MCF 7; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; IC 50; IN VITRO STUDY; LIVER CANCER; PLANT LEAF; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; WITHANIA SOMNIFERA;

WITHANIA SOMNIFERA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CACO-2 CELLS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDIA; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT LEAVES; PLANT ROOTS; WITHANIA; WITHANOLIDES;

EID: 84896399483     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2013.871545     Document Type: Article

References (13)

1. Chaurasiya ND, Sangwan NS, Sabir F, Misra LN, Sangwan RS. 2012. Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal). Plant Cell Rep. 31:1889-1897.
2. Lal P, Misra LN, Sangwan RS, Tuli R. 2006. New withanolides from fresh berries of Withania somnifera. Z Naturforsch B. 61b:1143-1147.
3. Misra LN, Lal P, Sangwan RS, Sangwan NS, Uniyal GC, Tuli R. 2005. Unusually sulfated and oxygenated steroids from Withania somnifera leaves. Phytochemistry. 66:2702-2707.
4. Misra LN, Mishra P, Pandey A, Sangwan RS, Sangwan NS. 2012. 1,4-Dioxane and ergosterol derivatives from Withania somnifera roots. J Asian Nat Prod Res. 14:39-45.
5. Misra LN, Mishra P, Pandey A, Sangwan RS, Sangwan NS, Tuli R. 2008. Withanolides from Withania somnifera roots. Phytochemistry. 69:1000-1004.
6. Misra LN, Wouatsa NAV, Kumar S, Kumar VR, Tchoumbougnang F. 2013. Antibacterial cytotoxic activities and chemical composition of fruits of two Cameroonian Zanthoxylum species. J Ethnopharmacol. 148:74-80.
7. Prakash O, Khan F, Sangwan RS, Misra LN. 2013. ANN-QSAR model for virtual screening of Androstenedione C-skeleton containing phytomolecules and analogues for cytotoxic activity against human breast cancer cell line MCF-7. Comb Chem High Throughput Screen. 16:57-72.
8. Prakash O, Rout PK, Chanotiya C, Misra LN. 2012. Composition of essential oil, concrete, absolute and SPME analysis of Tagetes patula capitula. Ind Crops Prod. 37:195-199.
9. Sabir F, Sangwan RS, Singh J, Misra LN, Pathak N, Sangwan NS. 2011. Biotransformation of withanolides from cell suspension cultures of Withania somnifera (Dunal). Biotechnol Lett. 5:127-134.
10. Saxena M, Faridi U, Mishra R, Gupta MM, Darokar MP, Srivastava SK, Singh D, Luqman S, Khanuja SPS. 2007. Cytotoxic agents from Terminalia arjuna. Planta Med. 73:1486-1490.
11. Tuli R, Sangwan RS, Kumar S, Bhattacharya S, Misra LN, Mandal C, Raghubir R, Nath C, Trivedi PK, Tewari SK, et al. 2009. In: Tuli R, Sangwan RS, editors. Ashwagandha (Withania somnifera): a model Indian medicinal plant. New Delhi: CSIR. p. 1-296.
12. Wouatsa NAV, Misra LN, Francois T, Kumar S, Prakash O, Khan F, Kumar VR. 2013. Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylum species. Chem Central J. 7:125.
13. Wouatsa NAV, Misra LN, Kumar VR, Darokar MP, Francois T. forthcoming 2013b. Zantholic acid, a new monoterpenoid from Zanthoxylum zanthoxyloides. Nat Prod Res. (doi:10.1080/14786419.2013.811662).