The role of KIR2DS1 in multiple sclerosis - KIR in Portuguese MS patients

Journal of Neuroimmunology

Volumn 269, Issue 1-2, 2014, Pages 52-55

  Bettencourt, Andreia ^a   Silva, Ana Martins ^a,b   Carvalho, Cláudia ^a   Leal, Bárbara ^a   Santos, Ernestina ^b   Costa, Paulo P ^a,c   Silva, Berta M ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^c NATIONAL INSTITUTE OF HEALTH   (Portugal)

Author keywords

KIR; Multiple sclerosis; Natural killer cells; Portugal

Indexed keywords

HLA DRB1 ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; PROTEIN KIR2DS1; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; HLA DRB1 GENE; HUMAN; KIR2DS1 GENE; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; MULTIPLE SCLEROSIS; PORTUGAL; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

KIR; MULTIPLE SCLEROSIS; NATURAL KILLER CELLS; PORTUGAL;

ADOLESCENT; ADULT; CHILD; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PORTUGAL; RECEPTORS, KIR; YOUNG ADULT;

EID: 84896396741     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2014.01.009     Document Type: Article

References (20)

1. Beecham A.H., Patsopoulos N.A., Xifara D.K., Davis M.F., Kemppinen A., Cotsapas C., Shah T.S., Spencer C., Booth D., Goris A., Oturai A., Saarela J., Fontaine B., Hemmer B., Martin C., Zipp F., D'Alfonso S., Martinelli-Boneschi F., Taylor B., Harbo H.F., Kockum I., Hillert J., Olsson T., Ban M., Oksenberg J.R., Hintzen R., Barcellos L.F., Agliardi C., Alfredsson L., Alizadeh M., Anderson C., Andrews R., Sondergaard H.B., Baker A., Band G., Baranzini S.E., Barizzone N., Barrett J., Bellenguez C., Bergamaschi L., Bernardinelli L., Berthele A., Biberacher V., Binder T.M., Blackburn H., Bomfim I.L., Brambilla P., Broadley S., Brochet B., Brundin L., Buck D., Butzkueven H., Caillier S.J., Camu W., Carpentier W., Cavalla P., Celius E.G., Coman I., Comi G., Corrado L., Cosemans L., Cournu-Rebeix I., Cree B.A., Cusi D., Damotte V., Defer G., Delgado S.R., Deloukas P., Di Sapio A., Dilthey A.T., Donnelly P., Dubois B., Duddy M., Edkins S., Elovaara I., Esposito F., Evangelou N., Fiddes B., Field J., Franke A., Freeman C., Frohlich I.Y., Galimberti D., Gieger C., Gourraud P.A., Graetz C., Graham A., Grummel V., Guaschino C., Hadjixenofontos A., Hakonarson H., Halfpenny C., Hall G., Hall P., Hamsten A., Harley J., Harrower T., Hawkins C., Hellenthal G., Hillier C., et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 2013, 45:1353-1360.
2. Biassoni R., Ugolotti E., De Maria A. NK cell receptors and their interactions with MHC. Curr. Pharm. Des. 2009, 15:3301-3310.
3. Boyton R.J., Altmann D.M. Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease. Clin. Exp. Immunol. 2007, 149:1-8.
4. Brynedal B., Duvefelt K., Jonasdottir G., Roos I.M., Akesson E., Palmgren J., Hillert J. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS ONE 2007, 2:e664.
5. Dyment D.A., Ebers G.C., Sadovnick A.D. Genetics of multiple sclerosis. Lancet Neurol. 2004, 3:104-110.
6. Fusco C., Guerini F.R., Nocera G., Ventrella G., Caputo D., Valentino M.A., Agliardi C., Gallotti J., Morra V.B., Florio C., Clerici M., Lombardi M.L. KIRs and their HLA ligands in remitting-relapsing multiple sclerosis. J. Neuroimmunol. 2010, 229(1-2):232-237.
7. Garcia-Leon J.A., Pinto-Medel M.J., Garcia-Trujillo L., Lopez-Gomez C., Oliver-Martos B., Prat-Arrojo I., Marin-Banasco C., Suardiaz-Garcia M., Maldonado-Sanchez R., Fernandez-Fernandez O., Leyva-Fernandez L. Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients. Mol. Immunol. 2011, 48:1896-1902.
8. Graber J.J., Dhib-Jalbut S. Protective autoimmunity in the nervous system. Pharmacol. Ther. 2009, 121:147-159.
9. Hafler D.A., Compston A., Sawcer S., Lander E.S., Daly M.J., De Jager P.L., De Bakker P.I., Gabriel S.B., Mirel D.B., Ivinson A.J., Pericak-Vance M.A., Gregory S.G., Rioux J.D., McCauley J.L., Haines J.L., Barcellos L.F., Cree B., Oksenberg J.R., Hauser S.L. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 2007, 357:851-862.
10. Jones D.C., Edgar R.S., Ahmad T., Cummings J.R., Jewell D.P., Trowsdale J., Young N.T. Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility. Genes Immun. 2006, 7:576-582.
11. Lorentzen A.R., Karlsen T.H., Olsson M., Smestad C., Mero I.L., Woldseth B., Sun J.Y., Senitzer D., Celius E.G., Thorsby E., Spurkland A., Lie B.A., Harbo H.F. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. Ann. Neurol. 2009, 65:658-666.
12. Middleton D., Gonzalez F. The extensive polymorphism of KIR genes. Immunology 2010, 129:8-19.
13. Morandi B., Bramanti P., Bonaccorsi I., Montalto E., Oliveri D., Pezzino G., Navarra M., Ferlazzo G. Role of natural killer cells in the pathogenesis and progression of multiple sclerosis. Pharmacol. Res. 2008, 57:1-5.
14. Moretta A., Marcenaro E., Parolini S., Ferlazzo G., Moretta L. NK cells at the interface between innate and adaptive immunity. Cell Death Differ. 2008, 15:226-233.
15. Ordonez D., Sanchez A.J., Martinez-Rodriguez J.E., Cisneros E., Ramil E., Romo N., Moraru M., Munteis E., Lopez-Botet M., Roquer J., Garcia-Merino A., Vilches C. Multiple sclerosis associates with LILRA3 deletion in Spanish patients. Genes Immun. 2009, 10:579-585.
16. Shi F.D., Van Kaer L. Reciprocal regulation between natural killer cells and autoreactive T cells. Nat. Rev. Immunol. 2006, 6:751-760.
17. Silva A.M., Pereira C., Bettencourt A., Carvalho C., Couto A.R., Leite M.I., Marta M., Freijo M., Costa P.P., Mendonca D., Monteiro L., Armas J.B., Martins B. The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese multiple sclerosis population. J. Neurol. Sci. 2007, 258:69-74.
18. Silva A.M., Bettencourt A., Pereira C., Santos E., Carvalho C., Mendonca D., Costa P.P., Monteiro L., Martins B. Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis. Mult. Scler. 2009, 15:771-774.
19. Trachtenberg E.A. Understanding the role of natural killer cell receptors and their human leukocyte antigen ligands in multiple sclerosis. Ann. Neurol. 2009, 65:626-628.
20. Yeo T.W., De Jager P.L., Gregory S.G., Barcellos L.F., Walton A., Goris A., Fenoglio C., Ban M., Taylor C.J., Goodman R.S., Walsh E., Wolfish C.S., Horton R., Traherne J., Beck S., Trowsdale J., Caillier S.J., Ivinson A.J., Green T., Pobywajlo S., Lander E.S., Pericak-Vance M.A., Haines J.L., Daly M.J., Oksenberg J.R., Hauser S.L., Compston A., Hafler D.A., Rioux J.D., Sawcer S. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann. Neurol. 2007, 61:228-236.