Thrombolysis for acute ischemic stroke: Do patients treated out of hours have a worse outcome?

Journal of Stroke and Cerebrovascular Diseases

Volumn 23, Issue 3, 2014, Pages 427-432

  Fang, Kun ^a,b   Churilov, Leonid ^c,d   Weir, Louise ^b,c   Dong, Qiang ^a   Davis, Stephen ^b,c   Yan, Bernard ^b,c  

^a FUDAN UNIVERSITY   (China)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

clinical outcome; door to CT time; door to needle time; Ischemic stroke; mortality; nonworking hours; thrombolysis

Indexed keywords

ALTEPLASE;

ADULT; AGED; ARTICLE; AUSTRALIA; BRAIN ISCHEMIA; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOOR TO NEEDLE TIME; EMERGENCY WARD; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NEUROIMAGING; NONWORKING HOUR; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RETROSPECTIVE STUDY; TIME TO TREATMENT; WORKING TIME;

CLINICAL OUTCOME; DOOR-TO-CT TIME; DOOR-TO-NEEDLE TIME; ISCHEMIC STROKE; MORTALITY; NONWORKING HOURS; THROMBOLYSIS;

ADMINISTRATION, INTRAVENOUS; AFTER-HOURS CARE; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CEREBRAL ANGIOGRAPHY; DISABILITY EVALUATION; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TIME-TO-TREATMENT; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; VICTORIA;

EID: 84896375970     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2013.03.029     Document Type: Article

References (34)

1. J.R. Marler, B.C. Tilley, and M. Lu et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study Neurology 55 2000 1649 1655
2. W. Hacke, M. Kaste, and E. Bluhmki et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N Engl J Med 359 2008 1317 1329
3. K.R. Lees, E. Bluhmki, and R. von Kummer et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials Lancet 375 2010 1695 1703
4. P. Sandercock, J.M. Wardlaw, and R.I. Lindley et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (The Third International Stroke Trial [IST-3]): a randomised controlled trial Lancet 379 2012 2352 2363
5. D. Summers, A. Leonard, and D. Wentworth et al. Comprehensive overview of nursing and interdisciplinary care of the acute ischemic stroke patient: a scientific statement from the American Heart Association Stroke 40 2009 2911 2944
6. G.C. Fonarow, E.E. Smith, and J.L. Saver et al. Improving door-to-needle times in acute ischemic stroke: the design and rationale for the American Heart Association/American Stroke Association's Target: stroke initiative Stroke 42 2011 2983 2989
7. L.H. Schwamm, A. Pancioli, and J.E. Acker III et al. Recommendations for the establishment of stroke systems of care: recommendations from the American Stroke Association's Task Force on the Development of Stroke Systems Stroke 36 2005 690 703
8. M.J. Alberts, G. Hademenos, and R.E. Latchaw et al. Recommendations for the establishment of primary stroke centers. Brain attack coalition JAMA 283 2000 3102 3109
9. S.K. Kim, S.Y. Lee, and H.J. Bae et al. Pre-hospital notification reduced the door-to-needle time for iv t-PA in acute ischaemic stroke Eur J Neurol 16 2009 1331 1335
10. P.J. Lindsberg, O. Happola, and M. Kallela et al. Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatment Neurology 67 2006 334 336
11. A systems approach to immediate evaluation and management of hyperacute stroke. Experience at eight centers and implications for community practice and patient care. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group Stroke 28 1997 1530 1540
12. H.P. Adams Jr., G. del Zoppo, and M.J. Alberts et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists Stroke 38 2007 1655 1711
13. J.L. Saver Time is brain - quantified Stroke 37 2006 263 266
14. W.J. Kostis, K. Demissie, and S.W. Marcella et al. Weekend versus weekday admission and mortality from myocardial infarction N Engl J Med 356 2007 1099 1109
15. M.A. Peberdy, J.P. Ornato, and G.L. Larkin et al. Survival from in-hospital cardiac arrest during nights and weekends JAMA 299 2008 785 792
16. G. Saposnik, A. Baibergenova, and N. Bayer et al. Weekends: a dangerous time for having a stroke? Stroke 38 2007 1211 1215
17. J. Fang, G. Saposnik, and F.L. Silver et al. Association between weekend hospital presentation and stroke fatality Neurology 75 2010 1589 1596
18. Y.C. Tung, G.M. Chang, and Y.H. Chen Associations of physician volume and weekend admissions with ischemic stroke outcome in Taiwan: a nationwide population-based study Med Care 47 2009 1018 1025
19. J.S. McKinney, Y. Deng, and S.E. Kasner et al. Comprehensive stroke centers overcome the weekend versus weekday gap in stroke treatment and mortality Stroke 42 2011 2403 2409
20. M. Bodenant, D. Leys, and S. Debette et al. Intravenous thrombolysis for acute cerebral ischaemia: comparison of outcomes between patients treated at working versus nonworking hours Cerebrovasc Dis 30 2010 148 156
21. G.W. Hendey, B.E. Barth, and T. Soliz Overnight and postcall errors in medication orders Acad Emerg Med 12 2005 629 634
22. Y. Arabi, A. Alshimemeri, and S. Taher Weekend and weeknight admissions have the same outcome of weekday admissions to an intensive care unit with onsite intensivist coverage Crit Care Med 34 2006 605 611
23. J. Needleman, P. Buerhaus, and S. Mattke et al. Nurse-staffing levels and the quality of care in hospitals N Engl J Med 346 2002 1715 1722
24. R.J. Cubeddu, I. Cruz-Gonzalez, and T.J. Kiernan et al. ST-elevation myocardial infarction mortality in a major academic center "on-" versus "off-" hours J Invasive Cardiol 21 2009 518 523
25. S. Curtze, A. Meretoja, and S. Mustanoja et al. Does time of day or physician experience affect outcome of acute ischemic stroke patients treated with thrombolysis? A study from Finland Int J Stroke 7 2012 511 516
26. J.C. van Swieten, P.J. Koudstaal, and M.C. Visser et al. Interobserver agreement for the assessment of handicap in stroke patients Stroke 19 1988 604 607
27. H.P. Adams Jr., B.H. Bendixen, and L.J. Kappelle et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment Stroke 24 1993 35 41
28. T. Brott, H.P. Adams Jr., and C.P. Olinger et al. Measurements of acute cerebral infarction: a clinical examination scale Stroke 20 1989 864 870
29. J. Bamford, P. Sandercock, and M. Dennis et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction Lancet 337 1991 1521 1526
30. S.M. Davis, G.A. Donnan, and M.W. Parsons et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial Lancet Neurol 7 2008 299 309
31. Y.J. Tai, L. Weir, and P. Hand et al. Does a "code stroke" rapid access protocol decrease door-to-needle time for thrombolysis? Intern Med J 42 2011 1316 1324
32. K.C. Albright, R. Raman, and K. Ernstrom et al. Can comprehensive stroke centers erase the 'weekend effect'? Cerebrovasc Dis 27 2009 107 113
33. J.A. Sattin, S.E. Olson, and L. Liu et al. An expedited code stroke protocol is feasible and safe Stroke 37 2006 2935 2939
34. A.I. Qureshi, J.F. Kirmani, and M.A. Sayed et al. Time to hospital arrival, use of thrombolytics, and in-hospital outcomes in ischemic stroke Neurology 64 2005 2115 2120