Does time of day or physician experience affect outcome of acute ischemic stroke patients treated with thrombolysis? A study from Finland

International Journal of Stroke

Volumn 7, Issue 6, 2012, Pages 511-516

  Curtze, Sami ^a   Meretoja, Atte ^a   Mustanoja, Satu ^a   Putaala, Jukka ^a   Lindberg, Timo ^a   Leppa, Mika ^a   Tiainen, Marjaana ^a   Atula, Sari ^a   Tatlisumak, Turgut ^a   Kaste, Markku ^a   Stroke, Helsinki ^a   Artto, Ville ^b   Häppölä, Olli ^b   Lindsberg, Perttu J ^b   Piironen, Katja ^b   Pitkäniemi, Janne ^b   Rantanen, Kirsi ^b   Sairanen, Tiina ^b   Salonen, Oili ^b   Silvennoinen, Heli ^b   Soinne, Lauri ^b   Strbian, Daniel ^b   more..

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NONE

Author keywords

Acute stroke; Diurnal variation; Outcome; Physician experience; Seasonal variation; Thrombolytic therapy

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CIRCADIAN RHYTHM; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; FIBRINOLYTIC THERAPY; FINLAND; HUMAN; JOB EXPERIENCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHYSICIAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; SEASONAL VARIATION;

AGED; CIRCADIAN RHYTHM; CLINICAL COMPETENCE; FEMALE; FIBRINOLYTIC AGENTS; FINLAND; HUMANS; MALE; NEUROLOGY; PROSPECTIVE STUDIES; SEASONS; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84864012461     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2012.00795.x     Document Type: Article

References (25)

1. Marler JR, Price TR, Clark GL etal. Morning increase in onset of ischemic stroke. Stroke 1989; 20:473-476.
2. Turin TC, Kita Y, Rumana N etal. Stroke case fatality shows seasonal variation regardless of risk factor status in a Japanese population: 15-year results from the Takashima Stroke Registry. Neuroepidemiology 2009; 32:53-60.
3. Wang H, Sekine M, Chen X, Kagamimori S. A study of weekly and seasonal variation of stroke onset. Int J Biometeorol 2002; 47:13-20.
4. Saposnik G, Baibergenova A, Bayer N, Hachinski V. Weekends: a dangerous time for having a stroke? Stroke 2007; 38:1211-1215.
5. Janszky I, Ahnve S, Ljung R. Weekend versus weekday admission and stroke outcome in Sweden from 1968 to 2005. Stroke 2007; 38:1211-1215.
6. Hasegawa Y, Yoneda Y, Okuda S etal. The effect of weekends and holidays on stroke outcome in acute stroke units. Cerebrovasc Dis 2005; 20:325-331.
7. Reeves MJ, Smith E, Fonarow G, Hernandez A, Pan W, Schwamm LH. Off-hour admission and in-hospital stroke case fatality in the get with the guidelines-stroke program. Stroke 2009; 40:569-576.
8. Jauss M, Oertel W, Allendoerfer J, Misselwitz B, Hamer H. Bias in request for medical care and impact on outcome during office and non-office hours in stroke patients. Eur J Neurol 2009; 16:1165-1167.
9. Lees KR, Ford GA, Muir KW etal. Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register. QJM 2008; 101:863-869.
10. Bell CM, Redelmeier DA. Mortality among patients admitted to hospitals on weekends as compared with weekdays. N Engl J Med 2001; 345:663-668.
11. Cram P. Effects of weekend admission and hospital teaching status on in-hospital mortality. Am J Med 2004; 117:151-157.
12. Albright KC, Raman R, Ernstrom K etal. Can comprehensive stroke centers erase the 'weekend effect'? Cerebrovasc Dis 2009; 27:107-113.
13. Jauss M, Schütz HJ, Tanislav C, Misselwitz B, Rosenow F. Effect of daytime, weekday and year of admission on outcome in acute ischaemic stroke patients treated with thrombolytic therapy. Eur J Neurol 2009; 17:555-561.
14. Tung Y-C, Chang G-M, Chen Y-H. Associations of physician volume and weekend admissions with ischemic stroke outcome in Taiwan: a nationwide population-based study. Med Care 2009; 47:1018-1025.
15. Bodenant M, Leys D, Debette S etal. Intravenous thrombolysis for acute cerebral ischaemia: comparison of outcomes between patients treated at working versus nonworking hours. Cerebrovasc Dis 2010; 30:148-156.
16. Fonarow GC, Smith EE, Saver JL etal. Improving door-to-needle times in acute ischemic stroke: the design and rationale for the American Heart Association/American Stroke Association's Target: stroke initiative. Stroke 2011; 42:2983-2989.
17. Meretoja A, Putaala J, Tatlisumak T etal. Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke 2010; 41:1450-1458.
18. Hacke W, Kaste M, Fieschi C etal. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998; 352:1245-1251.
19. Elliott WJ. Circadian variation in the timing of stroke onset: a meta-analysis. Stroke 1998; 29:992-996.
20. Manfredini R, Gallerani M, Portaluppi F, Salmi R, Fersini C. Chronobiological patterns of onset of acute cerebrovascular diseases. Thromb Res 1997; 88:451-463.
21. Rhoney DH, Coplin WM, Lin Y, Frankel M, Lyden PD, Levine SR. Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis 2010; 19:40-48.
22. Turin TC, Kita Y, Murakami Y etal. Higher stroke incidence in the spring season regardless of conventional risk factors: Takashima stroke registry, Japan, 1988-2001. Stroke 2008; 39:745-752.
23. Lees KR, Bluhmki E, von Kummer R etal. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375:1695-1703.
24. Strbian D, Soinne L, Sairanen T etal. Ultraearly thrombolysis in acute ischemic stroke is associated with better outcome and lower mortality. Stroke 2010; 41:712-716.
25. Lindsberg PJ, Häppölä O, Kallela M, Valanne L, Kuisma M, Kaste M. Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatment. Neurology 2006; 67:334-336.