Human non-pigmented ciliary epithelium bradykinin B2-receptors: Receptor localization, pharmacological characterization of intracellular ca2+ mobilization, and prostaglandin secretion

Current Eye Research

Volumn 39, Issue 4, 2014, Pages 378-389

  Sharif, Najam A ^a   Wang, Yu ^a   Katoli, Parvaneh ^a   Xu, Shouxi ^a   Kelly, Curtis R ^a   Li, Linya ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

Bradykinin; Non pigmented ciliary epithelium; Pharmacology; Receptors

Indexed keywords

BRADYKININ B2 RECEPTOR; ICATIBANT; NITRIC OXIDE; PROSTAGLANDIN; CALCIUM;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CHO CELL; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MACACA FASCICULARIS; NON PIGMENTED CILIARY EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; TRABECULAR MESHWORK; AGED; ANIMAL; BIOSYNTHESIS; BOVINE; CELL CULTURE; CILIARY BODY; DRUG EFFECTS; HAMSTER; INTRACELLULAR FLUID; MALE; METABOLISM; PATHOLOGY; RABBIT; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

AGED; ANIMALS; CALCIUM; CATTLE; CELLS, CULTURED; CILIARY BODY; CRICETINAE; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR FLUID; MACACA FASCICULARIS; MALE; PROSTAGLANDINS; RABBITS; RECEPTOR, BRADYKININ B2; SIGNAL TRANSDUCTION; TRABECULAR MESHWORK;

EID: 84896301959     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2013.816324     Document Type: Article

References (67)

1. Stone RA, Kuwayama Y, Laties AM. Regulatory peptides in the eye. Experentia 1987;43:791-800.
2. Kuwayama Y, Stone RA. Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye. Invest Ophthalmol Vis Sci 1987;28: 1947-1954.
3. Stone RA, Wilson CM, Glembotski CC. Chromatographic characterization of vasoactive intestinal polypeptide in guinea pig and rhesus monkey eyes. Curr Eye Res 1990;9: 287-291.
4. Rittig MG, Licht K, Funk RH. Innervation of the ciliary process vasculature and epithelium by nerve fibers containing catecholamines and neuropeptide Y. Ophthal Res 1993;25:108-118.
5. Grimes PA, McGlinn AM, Koeberlein B, Stone RA. Galanin immunoreactivity in autonomic innervations of the cat eye. J Comp Neurol 1994;348:234-243.
6. Ghosh S, Choritz L, Geibel J, Coca-Prados M. Somatostatin modulates PI3K-AKT, eNOS and NHE activity in the ciliary epithelium. Mol Cell Endocrinol 2006;253:63-75.
7. Katoli P, Sharif NA, Sule A, Dimitrijevich SD. NPR-B natriuretic peptide receptors in human corneal epithelium: mRNA, immunohistochemistochemical, protein and biochemical pharmacology studies. Mol Vis 2010;16: 1241-1252.
8. Ortego J, Coca-Prados M. Molecular characterization and differential gene induction of the neuroendocrine-specific genes neurotensin, neurotensin receptor, PC1, PC2 and 7B2 in the human ocular ciliary epithelium. J Neurochem 1996; 66:787-796.
9. Crook RB, Polansky JR. Neurotransmitters and neuropeptides stimulate inositol phosphates and intracellular calcium in cultured human nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci 1992;33:1706-1716.
10. Sharif NA, Xu SX. Pharmacological characterization of bradykinin receptors coupled to phosphoinositide turnover in SV40-immortalized human trabecular meshwork cells. Exp Eye Res 1996;63:631-637.
11. Wiernas TK, Griffin BW, Sharif NA. The expression of functionally-coupled bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br J Pharmacol 1997;121:649-656.
12. Wiernas TK, Davis TL, Griffin BW, Sharif NA. Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells. Br J Pharmacol 1998;123: 1127-1137.
13. Igic R. Kallikrein and kininases in ocular tissues. Exp Eye Res 1985;41:117-120.
14. Leeb-lundberg LM, Marceau F, Muller-Esteri W, Pettibone DJ, Zuraw B. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005;57:27-77.
15. Ma JX, Song Q, Hatcher HC, Crouch RK, Chao L, Chao J. Expression and cellular localization of the kallikrein-kinin system in human ocular tissues. Exp Eye Res 1996;63: 19-26.
16. Chowdhury UR, Madden BJ, Charlesworth MC, Fautch MP. Proteome analysis of human aqueous humor. Invest Ophthalmol Vis Sci 2010;51:4921-4931.
17. Burch RM, Axelrod J. Dissociation of bradykinin-stimulated arachidonic acid release from inositol phosphate formation in Swiss 3T3 fibroblasts. Evidence for a G protein-coupled phospholipase A2. Proc Natl Acad Sci USA 1987;84:6374-6378.
18. Polansky JR, Kurtz RM, Alvarado JA, Weinreb RN, Mitchell MD. Eicosanoid production and glucocorticoid regulatory mechanisms in cultured human trabecular meshwork cells. Prog Clin Biol Res 1989;312:113-138.
19. Proud D, Sweet J, Stein P, Settipane RA, Kagey-Sobotka A, Freidlaender MH, Lichtenstein LM. Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. J Allergy Clin Immunol 1990;85: 896-905.
20. Chiang TS. Effects of intravenous infusions of histamine 5-hydroxytryptamine, bradykinin and prostaglandins on intraocular pressure. Arch Int Pharmacodyn 1974;207: 131-138.
21. Kaufman PL, Barany EH, Erickson KA. Effect of serotonin, histamine and bradykinin on outflow facility following ciliary muscle retrodisplacement in the Cynomolgus monkey. Exp Eye Res 1982;35:191-199.
22. Cole DF, Unger WG. Action of bradykinin on intraocular pressure and papillary diameter. Ophthal Res 1974;6: 308-314.
23. Zeller EA, Shoch D, Czerner TB, Hsu MY, Knepper PA. Enzymology of the refractory media of the eye. X. effect of topically administered bradykinin, amine releasers, and pargyline on aqueous humor dynamics. Invest Ophthalmol 1971;10:274-281.
24. Yokoyama K, Awaya S, Mizumura K, Kumazawa T. Implication of polymodal receptor activities in intraocular pressure elevation by neurogenic inflammation. Jpn J Ophthalmol 1990;34:245-255.
25. Green K, Elijah D. Drug effects on aqueous humor formation and pseudofacility in normal rabbit eyes. Exp Eye Res 1981;33:239-245.
26. Bynke G, Hakanson R, Horig J, Leander S. Bradykinin contracts the papillary sphincter and evokes ocular inflammation through release of neuronal substance P. Eur J Pharmacol 1983;91:469-475.
27. Llobet A, Gual A, Pales J, Barraquar R, Tobias E, Nicolas JM. Bradykinin decreases outflow facility in perfuaed anterior segments and induces shape changes in passaged BTM cells in vitro. Invest Ophthalmol Vis Sci 1999;40: 113-125.
28. Webb JG, Husain S, Yates PW, Crosson CE. Kinin modulation of conventional outflow facility in bovine eye. J Ocular Pharmacol Ther 2006;22:310-316.
29. Weinreb RN, Mitchell MD, Polansky JR. Prostaglandin production by human trabecular cells: in vitro inhibition by dexamethasone. Invest Ophthalmol Vis Sci 1983;24: 1541-1545.
30. Webb JG, Shearer TW, Yates PW, Mukhin TV, Crosson CE. Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells. Exp Eye Res 2003;76:283-289.
31. Webb JG, Yang X, Crosson CE. Bradykinin activation of extracellular signal-regulated kinases in human trabecular meshwork cells. Exp Eye Res 2011;92:495-501.
32. Jacob TJ, Civan MM. Role of ion channels in aqueous humor formation. Am J Physiol 1996;271:C703-C720.
33. Shahidulla M, Delamere NA. NO donors inhibit Na, K-ATPase activity by a protein kinase G-dependent mechanism in the non-pigmented ciliary epithelium of the porcine eye. Br J Pharmacol 2006;148:871-880.
34. Coca-prados M, Escribano J. New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland. Prog Retina Eye Res 2007;26:239-262.
35. Coca-Prados M, Wax MB. Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of 2-adrenergic receptors. Proc Nat Acad Sci USA 1986;83:8754-8758.
36. Coca-Prados M, Lopez-Briones LG. Human nonpigmented ciliary epithelail cells in culture: a comparison study between normal versus transformed and fetal versus adult cells. Invest Ophthalmol Vis Sci 1987;28:10.
37. Wax MB, Coca-Prados M. Receptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells. Invest Ophthalmol Vis Sci 1989;30:1675-1679.
38. Crider JY, Sharif NA. Functional pharmacological evidence for EP2 and EP4 prostanoid receptors in immortalized human trabecular meshwork and non-pigmented ciliary epithelial cells. J Ocular Pharmacol Ther 2001;17:35-46.
39. Sharif NA, Senchyna M, Xu SX. Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells. J Ocular Pharmacol Ther 2002;18:141-162.
40. Sharif NA, Whiting RL. Identification of B2-bradykinin receptors in guinea pig brain regions, spinal cord and peripheral tissues. Neurochem Int 1991;18:89-96.
41. Sharif NA, Hunter JC, Hill RG, Hughes J. Bradykinininduced accumulation of [3H]inositol-1-phosphate in human embryonic pituitary tumor cells by activation of a B2-receptor. Neurosci Lett 1988;86:279-283.
42. Ransom J, Cherwinski HM, Dunne JF, Sharif NA. Flow cytometric analysis of internal calcium mobilization via a B2-bradykinin receptor in a subclone of PC12 cells. J Neurochem 1991;56:983-989.
43. Kelly CR, Williams GW, Sharif NA. Real-time intracellular Ca2+-mobilization by travoprost acid, bimatoprost, unoprostone and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J Pharmacol Exp Ther 2003;304:238-245.
44. Kelly CR, Sharif NA. Pharmacological evidence for a functional serotonin-2B receptor subtype in a human uterine smooth muscle cell line. J Pharmacol Expt Ther 2006;317:1254-1261.
45. Sharif NA, Crider JY, Kelly CR, Davis TL. Serotonin-2 (5HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. J Ocular Pharmacol Ther 2006;22:389-401.
46. Sharif NA, Kelly CR, McLaughlin MA. Human trabecular meshwork cells express functional serotonin-2 (5HT2) receptors: role in IOP reduction. Invest Ophthalmol Vis Sci 2006;47:4001-4010.
47. Busse R, Fleming I. Regulation and functional consequences of endothelial nitric oxide formation. Ann Med 1995;27:331-340.
48. Tsutsuie M, Onoue H, Iida Y, Smith L, OBrien T, Katusic ZS. B1 and B2 bradykinin receptors in adeventitial fibroblasts of cerebral arteries are coupled to recombinant eNOS. Am J Physiol Heart Circ Physiol 2000;278:H367-H372.
49. Offord E, Sharif NA, Mace K, Tromvoukis Y, Spillare E, Avanti OE, et al. Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci 1999;40:1091-1101.
50. Linder S, Marshall H. Immortalization of primary cells by DNA tumor viruses. Exp Cell Res 1990;191:1-7.
51. Sharif NA, McLaughlin MA, Kelly CR, Katoli P, Drace C, Husain S, et al. Cabergoline: pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in Cynomolgus monkey eyes. Exp Eye Res 2009;88:386-397.
52. Schild HO. pA2, a new scale for the measurement of drug antagonism. Br J Pharmacol 1947;2:189-206.
53. Kenakin T. Pharmacologic Analysis of Drug-Receptor Interactions. 2nd Edn. New York: Lipincott-Raven. 1993.
54. Rang HP. The receptor concept: pharmacologys big idea. Br J Pharmacol 2006;147:S9-S16.
55. Nahorski SR. Pharmacology of intracellular signaling pathways. Br J Pharmacol 2006;147:S38-S45.
56. Lands WEM. The biosynthesis and metabolism of prostaglandins. Ann Rev Physiol 1979;41:633-643.
57. Taylor L, Menconi M, Leibowitz HM, Polgar P. The effect of ascorbate, hydroperoxides, and bradykinin on prostaglandin production by corneal and lens cells. Invest Ophthalmol Vis Sci 1982;23:378-383.
58. Coleman AL, Miglior, S. Risk factors for glaucoma onset and progression. Surv Ophthalmol 2008;53:S3-S10.
59. Buchan KW, Martin W. Bradykinin induces elevations of cytosolic calcium through mobilization of intracellular and extracellular pools in bovine aortic endothelial cells. Br J Pharmacol 1991;102:35-40.
60. Lambert DG, Nahorski SR. Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route? J Physiol (Paris) 1992;86:77-82.
61. Tovell VE, Sanderson J. Distinct P2Y receptor subtypes regulate calcium signaling in human retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 2008;49: 350-357.
62. Snider RM, Richelson E. Bradykinin receptor-mediated cyclic GMP formation in a nerve cell population (murine neuroblastoma clone N1E-115). J Neurochem 1984;43: 1749-1754.
63. Shimuta S, Barbosa AMRB, Borges ACR, Paiva TB. Pharmacological characterization of RMP-7, a novel bradykinin agonist in smooth muscle. Immunopharmacol 1999; 45:63-67.
64. Sharif NA, Whiting RL. The neuropeptide bradykinin stimulates phosphoinositide turnover in HSDM1C1 cells: B2-antagonist-sensitive responses and receptor binding studies. Neurochem Res 1993;12:1313-1320.
65. Sharif NA, Xu S, Li L, Katoli P, Kelly CR, Wang Y, et al. Protein expression, biochemical pharmacology of signal transduction, and relation to IOP modulation by bradykinin B2-receptors in ciliary muscle. Molecular Vision 2013;19:1356-1370.
66. Patil R, Li L, Sharif NA. Activation of ERK signaling pathway by bradykinin B2-receptor in isolated human ciliary muscle cells. ARVO 2012; Abstract # 1971.
67. Duke-Elder S, Cook C. Normal and abnormal development. In: Duke-Elder S, editor. System of ophthalmology. Vol. III, Part 1 Embryology. St. Louis, MO, USA: The C.V. Mosby Company; 1963. pp 103-125.