Role of ion channels in aqueous humor formation

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Jacob, T J C ^b   Civan, M M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

calcium channels; chloride channels; multidrug resistance protein 1; nonpigmented ciliary epithelial cells; nonselective channels; pigmented ciliary epithelial cells; pl(Cln) protein; potassium channels; sodium channels

Indexed keywords

CHLORIDE CHANNEL; ION CHANNEL; POTASSIUM CHANNEL; SODIUM CHANNEL;

AQUEOUS HUMOR FORMATION; CELL SECRETION; CHLORIDE TRANSPORT; CILIARY BODY EPITHELIUM; HUMAN; NONHUMAN; PIGMENT EPITHELIUM; POTASSIUM TRANSPORT; PRIORITY JOURNAL; REVIEW; SODIUM TRANSPORT;

EID: 0029820492     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.3.c703     Document Type: Review

References (168)

1. Adachi, S., S. Uchida, H. Ito, M. Hata, M. Hiroe, F. Marumo, and S. Sasaki. Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. J. Biol. Chem. 269: 17677-17683, 1994.
2. Ahmad, I., C. Korbmacher, A. S. Segal, P. Cheung, E. L. Boulpaep, and C. J. Barnstable. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proc. Natl. Acad. Sci. USA 89: 10262-10266, 1992.
3. Ahmad, I., L. J. Redmond, and C. J. Barnstable. Developmental and tissue-specific expression of the rod photoreceptor cGMP-gated ion channel gene. Biochem. Biophys. Res. Commun. 173: 463-470, 1990.
4. Anderson, J. W., J. D. Jirsch, and D. Fedida. Cation regulation of anion current activated by swelling in two types of human epithelial cancer cells. J. Physiol. Land. 483: 549-557, 1995.
5. Cln, from ocular ciliary epithelium. Biochem. Biophys. Res. Commun. 208: 89-95, 1995.
6. Avenet, P., and B. Lindemann. Amiloride-blockable sodium currents in isolated taste receptor cells. J. Membr. Biol. 105: 245-255, 1988.
7. Bader, C. R., D. Bertrand, and E. A. Schwartz. Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina. J. Physiol. Lond. 331: 253-284, 1982.
8. Barres, B. A., L. L. Y. Chun, and D. P. Corey. Ion channels in vertebrate glia. Annu. Rev. Neurosci. 13: 441-474, 1990.
9. + channels in transformed cells of human non-pigmented ciliary epithelium. Curr. Eye Res. 10: 731-738, 1991.
10. 9a.Bean, B. P. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature Lond. 340: 153-156, 1989.
11. Benos, D. J., G. Saccomani, and S. Sariban-Sohrabi. The epithelial sodium channel. Subunit number and location of the amiloride binding site. J. Biol. Chem. 262: 10613-10618, 1987.
12. Blatz, A. L., and K. L. Magelby. Single voltage-dependent chloride selective channels of large conductance in cultured rat muscle. Biophys. J. 43: 237-241, 1983.
13. Bowler, J. M., D. Peart, R. D. Purves, D. A. Carré, A. D. C. Macknight, and M. M. Civan. Electron probe X-ray microanalysis of rabbit ciliary epithelium. Exp. Eye Res. 62: 627-640, 1996.
14. Brown, H., and D. DiFrancesco. Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node. J. Physiol. Lond. 308: 331-351, 1980.
15. Brubaker, R. F. Measurement of aqueous flow by fluorophotometry. In: The Glaucomas, edited by R. Ritch, M. B. Shields, and T. Krupin. St. Louis, MO: Mosby, 1989, p. 337-344.
16. Campbell, K. P., A. T. Leung, and A. H. Sharp. The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. Trends Neurosci. 11: 425-430, 1988.
17. + channel is made of three homologous subunits. Nature Lond. 367: 463-467, 1994.
18. Caprioli, J. The ciliary epithelia and aqueous humor. In: Adler's Physiology of the Eye: Clinical Application, edited by R. A. Moses and W. M. Hart, Jr. St. Louis, MO: Mosby, 1987, p. 204-222.
19. Carré, D. A., J. Anguíta, M. Coca-Prados, and M. M. Civan. Cell-attached patch clamping in the intact rabbit ciliary epithelium. Curr. Eye Res. In press.
20. Carré, D. A., and M. M. Civan. Cation-nonselective channels of intact ciliary epithelium (Abstract). Invest. Ophthalmol. Visual Sci. 35, Suppl.: 1455, 1994.
21. Carré, D. A., and M. M. Civan. cGMP modulates transport across the ciliary epithelium. J. Membr. Biol. 146: 293-305, 1995.
22. Carré, D. A., C.-S. R. Tang, T. Krupin, and M. M. Civan. Effect of bicarbonate on intracellular potential of rabbit ciliary epithelium. Curr. Eye Res. 11: 609-624, 1992.
23. Carré, D. A., R. E. Yantorno, and M. M. Civan. Cell-attached patch clamping of rabbit ciliary epithelium (Abstract). Invest. Ophthalmol. Visual Sci. 34, Suppl.: 1398, 1993.
24. Catterall, W. A., M. J. Seagar, and M. Takahashi. Molecular properties of the dihydropyridine-sensitive calcium channel. Science Wash. DC 242: 50-61, 1988.
25. Chalfant, M. L., T. G. O'Brien, and M. M. Civan. Whole cell and unitary amiloride-sensitive sodium currents in M-1 mouse cortical collecting duct cells. Am. J. Physiol. 270 (Cell Physiol. 39): C998-C1010, 1996.
26. Chen, S., R. Inoue, H. Imomata, and Y. Ito. Role of cyclic AMP-induced Cl conductance in aqueous humour formation by the dog ciliary epithelium. Br. J. Pharmacol. 112: 1137-1145, 1994.
27. 2+ influx through stretch-activated channels. Nature Lond. 330: 66-68, 1987.
28. 2+ on the short-circuit current of the isolated rabbit iris-ciliary body. Curr. Eye Res. 5: 511-516, 1986.
29. Cilluffo, M. C., B. N. Cohen, and G. L. Fain. Nonpigmented cells of the ciliary body epithelium: tissue culture and voltage gated currents. Invest. Ophthalmol. Visual Sci. 32: 1619-1629, 1991.
30. Civan, M. M., J. M. Bowler, S. Zellhuber-McMillan, D. Peart, D. A. Carré, R. D. Purves, and A. D. C. Macknight. Microanalysis of rabbit ciliary epithelium (Abstract). Invest. Ophthalmol. Visual Sci. 32, Suppl.: 978, 1991.
31. Civan, M. M., M. Coca-Prados, and K. Peterson-Yantorno. Pathways signalling the regulatory volume decrease of cultured non-pigmented ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 35: 2876-2886, 1994.
32. Civan, M. M., K. Peterson-Yantorno, M. Coca-Prados, and R. E. Yantorno. Regulatory volume decrease by cultured non-pigmented ciliary epithelial cells. Exp. Eye Res. 54: 181-191, 1992.
33. Cln. Am. J. Physiol. 268 (Cell Physiol. 37): C572-C579,1995.
34. Coca-Prados, M., S. Ghosh, N. B. Gigula, and N. M. Kumar. Expression and cellular distribution of the α1-gap junction gene product in the ocular pigmented ciliary epithelium. Curr. Eye Res. 11: 113-122, 1992.
35. - transport by human nonpigmented ciliary epithelial cells. J. Membr. Biol. 150: 197-208, 1996.
36. Cole, D. F. Aqueous humour formation. Doc. Ophthalmol. 21: 116-238, 1966.
37. Colquhoun, D., E. Neher, H. Reuter, and C. F. Stevens. Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature Lond. 294: 752-754, 1981.
38. Constanti, A., and M. Galvan. Fast inward-rectifying current acounts for anomalous rectification in olfactory cortex neurones. J. Physiol. Lond. 335: 153-178, 1983.
39. Cook, N. S. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. 9: 21-28, 1988.
40. Cooper, K., P. Gates, J. L. Rae, and J. Dewey. Electrophysiology of cultured human lens epithelila cells. J. Membr. Biol. 117: 285-298, 1990.
41. Cooper, K., J. L. Rae, and J. Dewey. Inwardly rectifying potassium current in mammalian lens epithelial cells. Am. J. Physiol. 261 (Cell Physiol. 30): C115-C123, 1991.
42. 2+ potentials in cells of the cat and rat lateral geniculate nucleus. J. Physiol. Lond. 413: 543-556, 1989.
43. + channel in colonic secretory cells. Am. J. Physiol. 265 (Cell Physiol. 34): C1271-C1280, 1993.
44. Dhallan, R. S., J. P. Macke, R. L. Eddy, T. B. Shows, R. R. Reed, K.-W. Yau, and J. Nathans. Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. J. Neurosci. 12: 3248-3256, 1992.
45. K2 in Purkinje fibres. J. Physiol. Lond. 308: 353-367, 1980.
46. Edelman, J. L., J. S. Adorante, and G. Sachs. Pigmented and non-pigmented cells of the bovine ciliary epithelium are functionally coupled and show a polarization of solute influx and efflux mechanisms (Abstract). Invest. Ophthalmol. Visual Sci. 34, Suppl.: 935, 1993.
47. Edelman, J. L., G. Sachs, and J. S. Adorante. Ion transport asymmetry and functional coupling in bovine pigmented and nonpigmented ciliary epithelial cells. Am. J. Physiol. 266 (Cell Physiol. 35): C1210-C1221, 1994.
48. Ehring, G. R., G. Zampighi, J. Horwitz, D. Bok, and J. E. Hall. Properties of channels reconstituted from the major intrinsic protein of lens fiber membranes. J. Gen. Physiol. 96: 631-634, 1990.
49. Fain, G. L., and N. A. Farahbakhsh. Voltage-activated currents recorded from rabbit pigmented ciliary body epithelial cells in culture. J. Physiol. Lond. 417: 83-103, 1989.
50. i in rabbit ciliary body epithelium. J. Physiol. Lond. 477.2: 215-221, 1994.
51. 2+ currents in rabbit ciliary body epithelial cells. Exp. Eye Res. 58: 197-206, 1994.
52. Farahbakhsh, N. A., and G. L. Fain. Volume regulation of non-pigmented cells from ciliary epithelium. Invest. Ophthalmol. Visual Sci. 28: 934-944, 1988.
53. Findlay, I. The effects of magnesium upon adenosine triphos-phosphate-sensitive potassium channels in a rat insulin-secreting cell line. J. Physiol. Lond. 391: 611-629, 1987.
54. Fox, A. P., M. C. Nowycky, and R. W. Tsien. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. Lond. 394: 149-172, 1987.
55. Fox, J. A., B. A. Pfeffer, and G. L. Fain. Single-channel recordings from cultured human retinal pigment epithelial cells. J. Gen. Physiol. 91: 193-222, 1988.
56. Franciolini, F., and W. Nonner. Anion and cation permeability of a chloride channel in rat hippocampal neurones. J. Gen. Physiol. 90: 453-478, 1987.
57. Franciolini, F., and W. Nonner. Anion-cation interactions in the pore of neuronal background chloride channels. J. Gen. Physiol. 104: 711-723, 1994.
58. + channel. Physiol. Rev. 68: 309-373, 1988.
59. - currents. Curr. Eye Res. 11: 1019-1029, 1992.
60. Green, K., C. Bountra, P. Georgiou, and C. R. House. An electrophysiologic study of rabbit ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 26: 371-381, 1985.
61. Hagiwara, S., and K. Takahashi. The anomalous rectification of a starfish egg cell. J. Physiol. Lond. 18: 61-80, 1974.
62. Halliwell, J. V., and P. R. Adams. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250: 71-92, 1982.
63. Harvey, R. D., and R. E. Ten Eick. On the role of sodium ions in the regulation of inwardly rectifying potassium conductance in cat ventricular myocytes. J. Gen. Physiol. 94: 329-348, 1989.
64. + transport of cultured bovine pigented ciliary epithelium. J. Membr. Biol. 99: 173-186, 1987.
65. Helbig, H., C. Korbmacher, J. Wohlfarth, M. T. Coroneo, C. Lindschau, P. Quass, H. Haller, M. Coca-Prados, and M. Wiederholt. Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 30: 890-896, 1989.
66. Hille, B. Ionic Channels of Excitable Membranes (2nd ed.). Sunderland, MA: Sinauer, 1992.
67. Ho, K., C. G. Nichols, W. J. Lederer, J. Lytton, P. M. Vassilev, M. V. Kanazirska, and S. C. Hebert. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature Lond. 362: 31-38, 1993.
68. Hodgkin, A. L., and A. F. Huxley. Currents carried by sodium and potassium through the membrane of the giant axon of Loligo. J. Physiol. Lond. 116: 473-496, 1952.
69. 67a.Jackson, P. S., and K. Strange. Current activation occurs by abrupt switching of closed channels to an open state. J. Gen. Physiol. 105: 643-660, 1995.
70. Jacob, T. J. C. Identification of a low-threshold T-type calcium channel in bovine ciliary epithelial cells. Am. J. Physiol. 261 (Cell Physiol. 30): C808-C813, 1991.
71. K(V). Am. J. Physiol. 261 (Cell Physiol. 30): C1055-C1062, 1991.
72. + -currents, iK(Ca) and iK(V), in isolated bovine pigmented ciliary epithelial cells, only iK(Ca) will contribute to ion transport (Abstract). J. Physiol. Land. 446: 36P, 1991.
73. Jacob, T. J. C., J. A. Bangham, and G. Duncan. Characterization of a cation channel on the apical surface of the frog lens epithelium. Q. J. Exp. Physiol. 70: 403-421, 1985.
74. Jacob, T. J. C., and C. H. Mitchell. Chloride current activated by hypotonic shock in pigmented ciliary epithelial cells. Invest. Ophthalmol. Visual Sci 36, Suppl.: S586, 1995.
75. Jan, L. Y., and Y. N. Jan. Potassium channels and their evolving gates. Nature Lond. 371: 119-122, 1994.
76. Jentsch, T. J. Molecular biology of voltage-gated chloride channels. Curr. Top. Membr. 42: 35-57, 1994.
77. Jentsch, T. J., W. Günther, M. Pusch, and B. Schwappach. Properties of voltage-gated chloride channels of the CIC gene family. J. Physiol. Lond. 482P: 19S-25S, 1995.
78. Karlson, K. H., F. Ciampolillo-Bates, D. E. McCoy, N. L. Kizer, and B. A. Stanton. Cloning of a cGMP-gated cation channel from mouse kidney inner medullary collecting duct. Biochim. Biophys. Acta 1236: 197-200, 1995.
79. Katz, B. Les constantes électriques de la membrane du muscle. Arch. Sci. Physiol. 3: 285-299, 1949.
80. Kaupp, U. B., T. Niidome, T. Tanabe, S. Tereda, W. Bonigk, W. Stuhmer, N. J. Cook, K. Kangawa, H. Matsuo, T. Hirose, T. Miyata, and S. Numa. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature Lond. 342: 762-766, 1989.
81. Kawasaki, M., S. Uchida, T. Monkawa, A. Miyawaki, K. Mikoshiba, F. Marumo, and S. Saskai. Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron 12: 597-604, 1994.
82. Kawasaki, M., S. Uchida, S. Sasaki, and F. Marumo. Single-channel currents of cloned CIC-3 channels in stably transfected cells. J. Am. Soc. Nephrol. 5: 288, 1994.
83. Kell, M. J., and L. J. DeFelice. Surface charge near the cardiac inward-rectifier channel measured from single-channel conductance. J. Membr. Biol. 102: 1-10, 1988.
84. Kieferle, S., P. Y. Fong, M. Bens, A. Vandewalle, and T. J. Jentsch. Two highly homologous members of the CIC chloride channel family in both rat and human kidney. Proc. Natl. Acad. Sci. USA 91: 6943-6947, 1994.
85. Korbmacher, C., A. S. Segal, G. Fejes-Tóth, G. Giebisch, and E. Boulpaep. Whole-cell currents in single and confluent M-1 mouse cortical collecting duct cells. J. Gen. Physiol. 102: 761-793, 1993.
86. Cln. Cell 76: 439-448, 1994.
87. Krupin, T., and M. M. Civan. The physiologic basis of aqueous humor formation. In: The Glaucomas (2nd ed.), edited by R. Ritch, M. B. Shields, and T. Krupin. St. Louis, MO: Mosby, 1995, p. 251-280.
88. Kubo, Y., T. J. Baldwin, Y. N. Jan, and L. Y. Jan. Primary structure and functional expressin of a mouse inward rectifier potassium channel. Nature Lond. 362: 127-133, 1993.
89. - channel currents in cultured human epithelial cells. J. Physiol. Lond. 456: 351-371, 1992.
90. Light, D. B., E. M. Schwiebert, K. H. Karlson, and B. A. Stanton. Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells. Science Wash. DC 243: 383-385, 1989.
91. Llinas, R., M. Sugimori, J. W. Lin, and B. Cherksey. Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from the funnel-web spider poison. Proc. Natl. Acad. Sci. USA 86: 349-354, 1989.
92. Lui, G. M., J. A. Alvarado, and J. R. Polansky. Isolation and serial propagation of human nonpigmented ciliary epithelium in tissue culture (Abstract). Invest. Ophthalmol. Visual Sci. 27, Suppl.: 163, 1986.
93. Mangel, A. W., J. R. Raymond, and J. G. Fitz. Regulation of high conductance anion channels by G proteins and 5-HT1A receptors in CHO cells. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F490-F499, 1993.
94. Martin-Vasallo, P., S. Ghosh, and M. Coca-Prados. Expression of Na,K-ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells. J. Cell. Physiol. 141: 243-252, 1989.
95. Marx, A., J. Siara, and R. Rudel. Sodium and potassium channels in epithelial cells from thymus glands and thymomas of myasthenia gravis patients. Pfluegers Arch. 417: 537-539, 1991.
96. + channels in guineapig heart cells. J. Physiol. Lond. 435: 83-99, 1991.
97. Matsuda, H., and P. R. Stanfield. Single inwardly rectifying potassium channels in cultured muscle cells from rat and mouse. J. Physiol. Lond. 414: 111-124, 1989.
98. Mayer, M. L., and G. L. Westbrook. A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones. J. Physiol. Lond. 340: 19-45, 1983.
99. K1 channels. J. Membr. Biol. 116: 41-45, 1990.
100. McCann, F. V., D. C. McCarthy, T. M. Keller, and R. J. Noelle. Characterization of a large-conductance non-selective channel in B lymphocytes. Cell. Signalling 1: 31-44, 1989.
101. McCannel, C. A., P. D. Scanlon, S. Thibodeau, and R. F. Brubaker. A study of aqueous humor formation in patients with cystic fibrosis. Invest. Ophthalmol. Visual Sci. 33: 160-164, 1992.
102. McClatchey, A. L., S. C. Cannon, S. A. Slaugenhaupt, and J. F. Gusella. The cloning and expression of a sodium channel β1-subunit cDNA from human brain. Hum. Mol. Genet. 2: 745-749, 1993.
103. McGill, J. M., S. Basavappa, and J. G. Fitz. Characterization of high-conductance anion channels in rat bile duct epithelial cells. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G703-G710, 1992.
104. McKinney, L. C., and E. K. Gallin. Inwardly rectifying whole-cell and single-channel K currents in the murine macro-phage cell line J774.1. J. Membr. Biol. 103: 41-53, 1988.
105. Miley, H. E., P. D. Alexander, S. W. Li, T. J. C. Jacob, and C. E. Pollard. Chloride conductance in freshly isolated pigmented ciliary body epithelial cells. J. Physiol. Lond. 489P: 97P, 1995.
106. Miley, H. E., V. E. Walker, C. E. Pollard, and T. J. C. Jacob. Regulatory volume increase in ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 36: S586, 1995.
107. Mitchell, C. H., and T. J. C. Jacob. Single channel memory: the open probability of a large conductance cation channel in isolated bovine pigmented ciliary epithelial cells (Abstract). J. Physiol. Lond. 467: 335P, 1993.
108. Mitchell, C. H., and T. J. C. Jacob. Two maxi-conductance channel types in bovine pigmented ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 35, Suppl.: 1455, 1994.
109. Mitchell, C. H., and T. J. C. Jacob. Hypotonically-activated and GTP-γS-activated chloride currents in bovine pigmented ciliary epithelial cells both require activity of phospholipase C. J. Physiol. Lond. 478P: 101, 1995.
110. Mitchell, C. H., and T. J. C. Jacob. A non-selective high conductance channel in bovine pigmented ciliary epithelial cells. J. Membr. Biol. 150: 105-111, 1996.
111. Moody-Corbett, F., and R. Gilbert. Inward rectifier potassium current on embryonic Xenopus muscle cells at different times in culture. Dev. Brain Res. 35: 139-142, 1990.
112. Moorman, J. R., C. J. Palmer, J. E. John III, M. E. Durieux, and L. R. Jones. Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes. J. Biol. Chem. 267: 14551-14554, 1992.
113. Morrison, B. W., J. R. Moorman, G. P. Kowdley, Y. M. Kobayashi, L. R. Jones, and P. Leder. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. J. Biol. Chem. 270: 2176-2182, 1995.
114. Nelson, D. J., J. M. Tang, and L. G. Palmer. Single-channel recordings of apical membrane chloride conductance in A6 epithelial cells. J. Membr. Biol. 80: 81-89, 1984.
115. Noble, D. Electrical properties of cardiac muscle attributable to inward-going (anomalous) rectification. J. Cell. Comp. Physiol. 66, Suppl. 2: 127-136, 1965.
116. Oh, J., T. Krupin, L. Q. Tang, J. Sveen, R. A. Lahlum. Dye coupling of rabbit ciliary epithelial cells in vitro. Invest. Ophthalmol. Visual Sci. 35: 2509-2514, 1994.
117. Oh, Y. S., and D. J. Benos. Amiloride-sensitive sodium channels. In: Amiloride and Its Analogs: Unique Cation Transport Inhibitors, edited by E. J. Cragoe, Jr., T. R. Kleyman, and L. Simchowitz. New York: VCH, 1992, p. 41-56.
118. Palmer, L. G. Epithelial Na channels: function and diversity. Annu. Rev. Physiol. 54: 51-66, 1992.
119. Partridge, L. D., and D. Swandulla. Calcium-activated non-specific cation channels. Trends Neurosci. 11: 69-72, 1988.
120. Paulmichl, M., Y.Li, K. Wickman, M. Ackerman, E. Peralta, and D. Clapham. New mammalian chloride channel identified by expression cloning. Nature Lond. 356: 238-241, 1992.
121. Pongs, O. Molecular biology of voltage-dependent potassium channels, Physiol. Rev. 72: S69-S88, 1992.
122. Rae, J. L., and R. A. Levis. Patch clamp recordings from the epithleium of the lens obtained using glasses selected for low noise and improved sealing properties. Biophys. J. 45: 144-146, 1984.
123. 123a.Rane, S. G., M. P. Walsh, J. R. McDonald, and K. Dunlap. Specific inhibitors of protein kinase C block transmitter-induced modulation of sensory neuron calcium current. Neuron 3: 239-245, 1989.
124. Raviola, G., and E. Raviola. Intercellular junctions in the ciliary epithelium. Invest. Ophthalmol. Visual Sci. 17: 958-981, 1978.
125. Riordan, J. R., J. M. Rommens, B.-S. Kerem, N. Aloni, R. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, J.-L. Chou, M. L. Drumm, M. C. lannuzzi, F. S. Collins, and L.-C. Tsui. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science Wash. DC 245: 1066-1080, 1989.
126. Rohen, J. W., and E. Lütjen-Drecoll. Morphology of aqueous outflow pathways in normal and glaucomatous eyes. In: The Glaucomas, edited by R. Ritch, M. B. Shields, and T. Krupin. St. Louis, MO: Mosby, 1989, p. 41-74.
127. Sakmann, B., and G. Trube. Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart. J. Physiol. Lond. 347: 641-657, 1984.
128. Schlichter, L. C., R. Grygorezk, P. A. Pahapill, and C. Grygorezk. A large multiple-conductance chloride channel in normal human lymphocytes. Pfluegers Arch. 416: 413-421, 1990.
129. Schwarze, W., and H.-A. Kolb. Voltage-dependent kinetics of an anionic channel of large unit conductance in macrophages and myotube membrane. Pfluegers Arch. 402: 281-291, 1984.
130. Sears, M. L., E. Yamada, D. Cummins, N. Mori, A. Mead, and M. Murakami. The isolated ciliary bilayer is useful for studies of aqueous humor formation. Trans. Am. Ophthalmol. Soc. 89: 131-152, 1991.
131. + conductance in the toad retinal pigment epithelium. J. Physiol. Lond. 476: 41-53, 1994.
132. Siemen, D. Nonselective cation channels. In: Nonselective Cation Channels: Pharmacology, Physiology and Biophysics, edited by D. Siemen and J. Hescheler. Basel: Birkhäuser Verlag, 1993, p. 3-26.
133. Siemen, D., and J. Hescheler (Editors). Nonselective Cation Channels: Pharmacology, Physiology and Biophysics. Basel: Birkhäuser Verlag, 1993.
134. + channels.Annu. Rev. Physiol. 53: 509-530, 1991.
135. 2+ channels: diversity of form and function. Curr. Opin. Neurobiol. 2: 247-253, 1992.
136. 135a.Stamer, W. D., R. W. Snyder, B. L. Smith, P. Agre, and J. W. Regan. Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance. Invest. Ophthalmol. Visual Sci. 35: 3867-3872, 1994.
137. Standen, N. B., and P. R. Stanfield. Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. J. Physiol. Lond. 294: 497-520, 1979.
138. + channels in isolated bovine pigmented ciliary epithelial cells (Abstract). J. Physiol. Lond. 459: 180P, 1993.
139. + current underlies oscillatory membrane potential behaviour in bovine pigmented ciliary epithelial cells. J. Physiol. Lond. 458: 439-456, 1992.
140. Stelling, J. W., and T. J. C. Jacob. Membrane potential oscillation from a novel combination of ion channels. Am. J. Physiol. 265 (Cell Physiol. 34): C720-C727, 1993.
141. + channels by carbachol in bovine pigmented ciliary body epithelial cells. Am. J. Physiol 271 (Cell Physiol. 40): C203-C209, 1996.
142. Stelling, J. W., C. H. Mitchell, and T. J. C. Jacob. Ion channels underlying membrane potential oscillations in pigmented ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 34: 1445, 1993.
143. Sun, X. P., S. Supplisson, R. Torres, G. Sachs, and E. Mayer. Characterizaztion of large-conductance chloride channels in rabbit colonic smooth muscle. J. Physiol. Lond. 448: 355-382, 1992.
144. Tabcharani, J. A., J. M. Rommens, Y. X. Hou, X. B. Chang, L. C. Tsui, J. R. Riordan, and J. W. Hanrahan. Multi-ion pore behavior in the CFTR chloride channel. Nature Lond. 366: 79-82, 1993.
145. 143a.Tamaoki, T. Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors. Methods Enzymol. 201: 340-347, 1991.
146. Trimmer, J. S., and W. S. Agnew. Molecular diversity of voltage-sensitive Na channels. Annu. Rev. Physiol. 51: 401-418, 1989.
147. 2+ channels. Trends Pharmacol. Sci. 12: 349-354, 1991.
148. Uchida, S., S. Sasaki, T. Furukawa, M. Hiraoka, T. Imai, Y. Hirata, and F. Marumo. Molecular cloning of a chloride chanel that is regulated by dehydration and expressed predominantly in kidney medulla. J. Biol. Chem. 268: 3821-3824, 1993.
149. Vaca, L., and D. L. Kunze. Anion and cation permeability of a large conductance anion in T84 human colonic cell line. J. Membr. Biol. 130: 241-249, 1992.
150. Valverde, M. A., M. Díaz, F. V. Sepúlveda, D. R. Gill, S. C. Hyde, and C. F. Higgins. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature Lond. 355: 830-833, 1992.
151. Van Slegtenhorst, M. A., M. T. Bassi, G. Borsani, M. C. Wapenaar, G. B. Ferrero, L. de Conciliis, E. I. Rugarli, A. Grillo, B. Franco, H. Y. Zoghbi, H. Y., and A. Ballabio. A gene from the Xp22.3 region shares homology with voltage-gated chloride channels. Hum. Mol Genet. 3: 547-552, 1994.
152. Velasco, G., M. Prieto, J. Alvarez-Rieva, S. Gascon, and F. Barros. Characteristics and regulation of a high conductance anion channel in GBK kidney epithelial cells. Pfluegers Arch. 414: 304-310, 1989.
153. Voboril, J. E., and R. B. Crook. Regulation of natriuretic piptide B receptors by protein kinase C is ligand-dependent in human NPE cells. Invest. Ophthalmol. Visual Sci. 36: S408, 1995.
154. Walker, V. E., H. M. Miley, N. Camodeca, J. W. Stelling, C. E. Pollard, and T. J. C. Jacob. Cell volume, membrane potential and coupling in bovine ciliary epithelial cells. Invest. Ophthalmol. Visual Sci. 36: S590, 1995.
155. Watsky, M. A., K. Cooper, and J. L. Rae. Sodium channels in ocular epithelia. Pfluegers Arch. 419: 454-459, 1991.
156. Welsh, M. J., and J. D. McCann. Intracellular calcium regulates basolateral potassium channels in a chloride-secreting epithelium. Proc. Natl. Acad. Sci. USA 82: 8823-8826, 1985.
157. + current in cultured human retinal pigment epithelial cells. J. Physiol. Lond. 476.2: 187-196, 1994.
158. Wiederholt, M., C. Flügel, E. Lütjen-Drecoll, and J. A. Zadunaisky. Mechanically stripped pigmented and nonpigmented epithelium of the shark ciliary body: morphology and transepithelial electrical properties. Exp. Eye Res. 49: 1031-1043, 1989.
159. Wiederholt, M., H. Helbig, and C. Korbmacher. Ion transport across the ciliary epithelium: lessons from cultured cells and proposed role of the carbonic anhydrase. In: Carbonic Anhydrase, edited by F. Botre, G. Gross, and B. Storey. Weinheim, Germany: VCH Verlagsgesellschaft, 1991, p. 232-244.
160. Wiederholt, M., and J. A. Zadunaisky. Membrane potentials and intracellular chloride activity in the ciliary body of the shark. Pfluegers Arch. 407, Suppl. 2: S112-S115, 1986.
161. Woll, K. H., M. D. Leibowitz, B. Neumke, and B. Hille. A high-conductance anion channel in adult amphibian skeletal muscle. Pfluegers Arch. 410: 632-640, 1987.
162. Wolosin, J. M., J. A. Bonanno, and T. E. Machen. Bicarbonate transport mechanism in rabbit ciliary body epithelium. Exp. Eye Res. 52: 397-407, 1991.
163. Wolosin, J. M., M. Chen, R. E. Gordon, Z. Stegman, and G. A. Butler. Separation of the rabbit ciliary body epithelial layers in viable form: identification of differences in bicarbonate transport. Exp. Eye Res. 56: 401-409, 1993.
164. Wu, J., and T. J. C. Jacob. Small conductance, volume-activated chloride channels in isolated nonpigmented ciliary epithelial cells of bovine eye. Invest. Ophthalmol. Visual Sci. 35, Suppl.: 1454, 1994.
165. Wu, J., J. J. Zhang, H. Koppel, and T. J. C. Jacob. Evidence for an association between P-glycoprotein and volume-activated chloride currents in non-pigmented ciliary epithelial cells. J. Physiol. Lond. 491.3: 743-755, 1996.
166. Yanagihara, K., and H Irisawa. Inward current activated during hyperpolarization in the rabbit sino atrial node. Pfluegers Arch. 385: 11-19, 1980.
167. Yantorno, R. E., D. A. Carré, M. Coca-Prados, T. Krupin, and M. M. Civan. Whole cell patch clamping of ciliary epithelial cells during anisosmotic swelling. Am. J. Physiol. 262 (Cell Physiol. 31): C501-C509, 1992.
168. Yantorno, R. E., M. Coca-Prados, T. Krupin, and M. M. Civan. Volume regulation of cultured, transformed, nonpigmented epithelial cells from human ciliary body. Exp. Eye Res. 49: 423-437, 1989.