Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Sutalangka, Chatchada ^a,b   Wattanathorn, Jintanaporn ^a,b   Muchimapura, Supaporn ^a,b   Thukham Mee, Wipawee ^a,b  

^a KHON KAEN UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; HEALTH CARE; MEDICINE;

ACHE ACTIVITIES; ACTIVE INGREDIENTS; MORINGA OLEIFERA; NEURODEGENERATION; NEUROPROTECTION; POSSIBLE MECHANISMS; PREVENTIVE STRATEGIES; THERAPEUTIC EFFICACY;

NEURODEGENERATIVE DISEASES;

ACETYLCHOLINESTERASE; ANTIOXIDANT; ASCORBIC ACID; CATALASE; DONEPEZIL; ETHYLCHOLINE MUSTARD AZIRIDINIUM; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MORINGA OLEIFERA EXTRACT; NEUROPROTECTIVE AGENT; SUPEROXIDE DISMUTASE; BIOLOGICAL MARKER; PLANT EXTRACT;

ADULT; AGE RELATED DEMENTIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DEMENTIA; DENSITY; DENTATE GYRUS; DRUG MEGADOSE; ENZYME ACTIVITY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LATENT PERIOD; LOW DRUG DOSE; MALE; MEMORY; MEMORY DISORDER; MORINGA OLEIFERA; MORRIS WATER MAZE TEST; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; SPATIAL MEMORY; YOUNG ADULT; AGING; ANIMAL; BIOLOGICAL MODEL; CELL COUNT; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; ESCAPE BEHAVIOR; LIPID PEROXIDATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYTOTHERAPY; WISTAR RAT;

ACETYLCHOLINESTERASE; AGING; ANIMALS; BIOLOGICAL MARKERS; CELL COUNT; DEMENTIA; DISEASE MODELS, ANIMAL; ESCAPE REACTION; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MEMORY; MEMORY DISORDERS; MODELS, BIOLOGICAL; MORINGA OLEIFERA; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

EID: 84896300131     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/695936     Document Type: Article

References (50)

1. Prince M., Bryce R., Albanese E., Wimo A., Ribeiro W., Ferri C. P., The global prevalence of dementia: a systematic review and metaanalysis. Alzheimer's Dementia 2013 9 1 63 75
2. Brookmeyer R., Johnson E., Ziegler-Graham K., Arrighi H. M., Forecasting the global burden of Alzheimer's disease. Alzheimer's and Dementia 2007 3 3 186 191 2-s2.0-34249697099 10.1016/j.jalz.2007.04.381 (Pubitemid 46825511)
3. Mattson M. P., Pathways towards and away from alzheimer's disease. Nature 2004 430 7000 631 639 2-s2.0-3943092621 10.1038/nature02621 (Pubitemid 39061671)
4. Wolf H., Grunwald M., Kruggel F., Riedel-Heller S. G., Angerhöfer S., Hojjatoleslami A., Hensel A., Arendt T., Gertz H.-J., Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of Aging 2001 22 2 177 186 2-s2.0-0035109434 10.1016/S0197-4580(00)00238-4 (Pubitemid 32162966)
5. Doggrell S. A., Evans S., Treatment of dementia with neurotransmission modulation. Expert Opinion on Investigational Drugs 2003 12 10 1633 1654 2-s2.0-0142241352 10.1517/13543784.12.10.1633 (Pubitemid 37322321)
6. Valls-Pedret C., Lamuela-Raventós R. M., Medina-Remón A., Quintana M., Corella D., Pintó X., Martínez-González M. Á., Estruch R., Ros E., Polyphenol-rich foods in the mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. Journal of Alzheimer's Disease 2012 29 4 773 782 2-s2.0-84860205395 10.3233/JAD-2012-111799
7. Ataie A., Sabetkasaei M., Haghparast A., Moghaddam A. H., Kazeminejad B., Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacology Biochemistry and Behavior 2010 96 4 378 385 2-s2.0-77956061835 10.1016/j.pbb.2010.06.009
8. Craggs L., Kalaria R. N., Revisiting dietary antioxidants, neurodegeneration and dementia. NeuroReport 2011 22 1 1 3 2-s2.0-79551538975 10.1097/WNR.0b013e328342741c
9. Bennett R. N., Mellon F. A., Foidl N., Pratt J. H., Dupont M. S., Perkins L., Kroon P. A., Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (Horseradish tree) and Moringa stenopetala L. Journal of Agricultural and Food Chemistry 2003 51 12 3546 3553 2-s2.0-0038012782 10.1021/jf0211480
10. Aslam M., Anwar F., Nadeem R., Rashid U., Kazi T. G., Nadeem M., Mineral composition of Moringa oleifera leaves and pods from different regions of Panjab. Asian Journal of Plant Sciences 2005 4 417 421
11. Manguro L. O. A., Lemmen P., Phenolics of Moringa oleifera leaves. Natural Product Research 2007 21 1 56 68 2-s2.0-33847253353 10.1080/ 14786410601035811 (Pubitemid 46322953)
12. Amaglo N. K., Bennett R. N., Lo Curto R. B., Rosa E. A. S., Lo Turco V., Giuffrida A., Curto A. L., Crea F., Timpo G. M., Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana. Food Chemistry 2010 122 4 1047 1054 2-s2.0-77951937329 10.1016/j.foodchem.2010.03.073
13. Gowrishankar R., Kumar M., Menon V., Divi S. M., Saravanan M., Magudapathy P., Panigrahi B. K., Nair K. G. M., Venkataramaniah K., Trace element studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) using PIXE. Biological Trace Element Research 2010 133 3 357 363 2-s2.0-77951625465 10.1007/s12011-009-8439-1
14. Bamishaiye E. I., Olayemi F. F., Awagu E. F., Bamshaiye O. M., Proximate and phytochemical composition of Moringa oleifera leaves at three stages of maturation. Advance Journal of Food Science and Technology 2011 3 4 233 237 2-s2.0-80955155690
15. Ijeomah A. U., Ugwuona F. U., Abdullahi H., Phytochemical composition and antioxidant properties of Hibiscus sabdariffa and Moringa oleifera. Nigerian Journal of Agriculture, Food and Environment 2012 8 1 10 16
16. Ugwu Okechukwu P. C., Nwodo Okwesili F. C., Joshua Parker E., Abubakar B., Ossai Emmanuel C., Odo Christian E., Phytochemical and acute toxicity studies of Moringa oleifera ethanol leaf extract. International Journal of Life Science BiotechNology and Pharma Research 2013 2 66 71
17. Asare G. A., Gyan B., Bugyei K., Adjei S., Mahama R., Addo P., Otu-Nyarko L., Wiredu E. K., Nyarko A., Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. Journal of Ethnopharmacology 2012 139 1 265 272 2-s2.0-83555174660 10.1016/j.jep.2011.11.009
18. Ganguly R., Guha D., Alteration of brain monoamines & EEG wave pattern in rat model of alzheimer's disease & protection by Moringa oleifera. Indian Journal of Medical Research 2008 128 6 744 751 2-s2.0-61849104057
19. Ganguly R., Hazra R., Ray K., Guha D., Effect of Moringa oleifera in experimental model of Alzheimer's disease: role of antioxidants. Annals of Neurosciences 2005 12 36 39
20. Thukhammee W., Wattanathorn J., Evaluation of safety and protective effect of combined extract of Cissampelospareira and Anethumgraveolens (PM52) against age-related cognitive impairment. Evidence-Based Complementary and Alternative Medicine 2012 2012 10 674101 10.1155/2012/674101
21. Hanin I., Mantione C. R., Fisher A., Cortin S., Davis K. L., Growdon J. H., Usdin E., Wurtman R. J., AF64A-induced neurotoxicity: a potential animal model in Alzheimer's disease. Alzheimer's Disease: A Report of Progress in Research 1982 17 New York, NY, USA Raven Press 267 270
22. Brandeis R., Brandys Y., Yehuda S., The use of the morris water maze in the study of memory and learning. International Journal of Neuroscience 1989 48 1-2 29 69 2-s2.0-0024730192
23. Ohkawa H., Ohishi N., Yagi K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979 95 2 351 358 2-s2.0-0018384650 (Pubitemid 9194347)
24. Ellman G. L., Courtney K. D., Andres V. Jr., Featherstone R. M., A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 1961 7 2 88 90 2-s2.0-33644811612
25. McCord J. M., Fridovich I., Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). Journal of Biological Chemistry 1969 244 22 6049 6055 2-s2.0-0014691242
26. Goldblith S. A., Proctor B. E., Photometric determination of catalase activity. The Journal of Biological Chemistry 1950 187 2 705 709 2-s2.0-74049147961
27. Eyer P., Podhradsky D., Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent. Analytical Biochemistry 1986 153 1 57 66 2-s2.0-0022596406 (Pubitemid 16142951)
28. Devi L., Diwakar L., Raju T. R., Kutty B. M., Selective neurodegeneration of hippocampus and entorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum. Brain Research 2003 960 1-2 9 15 2-s2.0-0037449444 10.1016/S0006-8993(02)03699-5 (Pubitemid 36050107)
29. Oswald C. J. P., Good M., The effects of combined lesions of the subicular complex and the entorhinal cortex on two forms of spatial navigation in the water maze. Behavioral Neuroscience 2000 114 1 211 217 2-s2.0-0034096468 10.1037//0735-7044.114.1.211 (Pubitemid 30131599)
30. O'Keefe J., Dostrovsky J., The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Research 1971 34 1 171 175 2-s2.0-0015145985
31. Liu P., Bilkey D. K., The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks. Behavioral Neuroscience 2001 115 1 94 111 2-s2.0-0035124076 (Pubitemid 32185154)
32. Hebert A. E., Dash P. K., Nonredundant roles for hippocampal and entorhinal cortical plasticity in spatial memory storage. Pharmacology Biochemistry and Behavior 2004 79 1 143 153 2-s2.0-4544224582 10.1016/j.pbb.2004.06.016 (Pubitemid 39237713)
33. Bannerman D. M., Deacon R. M. J., Offen S., Friswell J., Grubb M., Rawlins J. N. P., Double dissociation of function within the hippocampus: spatial memory and hyponeophagia. Behavioral Neuroscience 2002 116 5 884 901 2-s2.0-0036786050 10.1037//0735-7044.116.5.884
34. Moser M.-B., Moser E. I., Distributed encoding and retrieval of spatial memory in the hippocampus. Journal of Neuroscience 1998 18 18 7535 7542 2-s2.0-0032530951 (Pubitemid 28425835)
35. Lee I., Kesner R. P., Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory. Journal of Neuroscience 2003 23 4 1517 1523 2-s2.0-0037442796 (Pubitemid 36258930)
36. Haberman R. P., Lee H. J., Colantuoni C., Ming T. K., Gallagher M., Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region. Proceedings of the National Academy of Sciences of the United States of America 2008 105 30 10601 10606 2-s2.0-48749112988 10.1073/pnas.0804292105
37. Lee I., Yoganarasimha D., Rao G., Knierim J. J., Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 2004 430 6998 456 459 2-s2.0-3242799836 10.1038/nature02739 (Pubitemid 38987907)
38. Leutgeb S., Leutgeb J. K., Treves A., Moser M.-B., Moser E. I., Distinct ensemble codes in hippocampal areas CA3 and CA1. Science 2004 305 5688 1295 1298 2-s2.0-4344616877 10.1126/science.1100265 (Pubitemid 39129235)
39. Owen A. M., The functional organization of working memory processes within human lateral frontal cortex: the contribution of functional neuroimaging. European Journal of Neuroscience 1997 9 7 1329 1339 2-s2.0-0030818184 10.1111/j.1460-9568.1997.tb01487.x (Pubitemid 27303233)
40. Francis S. T., Head K., Morris P. G., Macdonald I. A., The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. Journal of Cardiovascular Pharmacology 2006 47 2 S215 S220 2-s2.0-33750305274 10.1097/00005344-200606001-00018 (Pubitemid 44620214)
41. Rossato J. I., Bevilaqua L. R. M., Izquierdo I., Medina J. H., Cammarota M., Dopamine controls persistence of long-term memory storage. Science 2009 325 5943 1017 1020 2-s2.0-69249146520 10.1126/science.1172545
42. Dangi S. Y., Jolly C. I., Narayanan S., Antihypertensive activity of the total alkaloids from the leaves of Moringa oleifera. Pharmaceutical Biology 2002 40 2 144 148 2-s2.0-0036064837 10.1076/phbi.40.2.144.5847 (Pubitemid 34765393)
43. Prabsattroo T., Wattanathorn J., Iamsa-ard S., Muchimapura S., Thukhammee W., Moringa oleifera leaves extract attenuates male sexual dysfunction. American Journal of Neuroscience 2012 3 1 17 24
44. Ganguly R., Guha D., Alteration of brain monoamines & EEG wave pattern in rat model of alzheimer's disease & protection by Moringa oleifera. Indian Journal of Medical Research 2008 128 6 744 751 2-s2.0-61849104057
45. Fukui K., Omoi N.-O., Hayasaka T., Shinnkai T., Suzuki S., Abe K., Urano S., Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Annals of the New York Academy of Sciences 2002 959 275 284 2-s2.0-0036240260 (Pubitemid 34457568)
46. Candelario-Jalil E., Mhadu N. H., Al-Dalain S. M., Martínez G., León O. S., Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neuroscience Research 2001 41 3 233 241 2-s2.0-0034765766 10.1016/S0168-0102(01)00282-6 (Pubitemid 32988398)
47. Saito K.-I., Elce J. S., Hamos J. E., Nixon R. A., Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in alzheimer disease: a potential molecular basis for neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America 1993 90 7 2628 2632 2-s2.0-0027474051 (Pubitemid 23113469)
48. Yu W., Mechawar N., Krantic S., Quirion R., Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in alzheimer disease. American Journal of Pathology 2010 176 5 2209 2218 2-s2.0-77952048948 10.2353/ajpath.2010.090496
49. Gorelick P. B., Scuteri A., Black S. E., Decarli C., Greenberg S. M., Iadecola C., Launer L. J., Laurent S., Lopez O. L., Nyenhuis D., Petersen R. C., Schneider J. A., Tzourio C., Arnett D. K., Bennett D. A., Chui H. C., Higashida R. T., Lindquist R., Nilsson P. M., Roman G. C., Sellke F. W., Seshadri S., Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011 42 9 2672 2713 2-s2.0-80052400687 10.1161/STR. 0b013e3182299496
50. Youdim K. A., Joseph J. A., A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radical Biology and Medicine 2001 30 6 583 594 2-s2.0-0035868503 10.1016/S0891-5849(00)00510-4 (Pubitemid 32280784)