Effects of cordycepin on HepG2 and EA.hy926 cells: Potential antiproliferative, antimetastatic and anti-angiogenic effects on hepatocellular carcinoma

Oncology Letters

Volumn 7, Issue 5, 2014, Pages 1556-1562

  Lu, Haisheng ^a   Li, Xiting ^a   Zhang, Jianying ^a   Shi, Hui ^b   Zhu, Xiaofeng ^a   He, Xiaoshun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Apoptosis; Cordycepin; Hepatocellular carcinoma; Invasion; Vascular endothelial cells

Indexed keywords

CORDYCEPIN;

ANGIOGENESIS; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; WOUND HEALING;

EID: 84896291631     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1965     Document Type: Article

References (47)

1. McGlynn KA and London WT: Epidemiology and natural history of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 19: 3-23, 2005.
2. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
3. Llovet JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet 362: 1907-1917, 2003.
4. Azam F and Koulaouzidis A: Hepatitis B virus and hepatocarcinogenesis. Ann Hepatol 7: 125-129, 2008.
5. Bosch FX, Ribes J, Diaz M and Cleries R: Primary liver cancer: worldwide incidence and trends. Gastroenterology 127 (5 Suppl 1): S5-S16, 2004.
6. Flamme I, Frolich T and Risau W: Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol 173: 206-210, 1997.
7. Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet 379: 1245-1255, 2012.
8. Lopez PM, Villanueva A and Llovet JM: Systematic review: evidence-based management of hepatocellular carcinoma - an updated analysis of randomized controlled trials. Aliment Pharmacol Ther 23: 1535-1547, 2006.
9. Cunningham KG, Manson W, Spring FS and Hutchinson SA: Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 166: 949, 1950.
10. Lennon MB and Suhadolnik RJ: Biosynthesis of 3'-deoxyadenosine by Cordyceps militaris. Mechanism of reduction. Biochim Biophys Acta 425: 532-536, 1976.
11. Tsai YJ, Lin LC and Tsai TH: Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J Agric Food Chem 58: 4638-4643, 2010.
12. Sugar AM and McCaffrey RP: Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob Agents Chemother 42: 1424-1427, 1998.
13. Jagger DV, Kredich NM and Guarino AJ: Inhibition of Ehrlich mouse ascites tumor growth by cordycepin. Cancer Res 21: 216-220, 1961.
14. Rich MA, Meyers P, Weinbaum G, Cory JG and Suhadolnik RJ: Inhibition of human tumor cells by cordycepin. Biochim Biophys Acta 95: 194-204, 1965.
15. Nakamura K, Yoshikawa N, Yamaguchi Y, et al: Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res 26: 43-47, 2006.
16. Wehbe-Janek H, Shi Q and Kearney CM: Cordycepin/hydroxyurea synergy allows low dosage efficacy of cordycepin in MOLT-4 leukemia cells. Anticancer Res 27: 3143-3146, 2007.
17. Lee SJ, Kim SK, Choi WS, Kim WJ and Moon SK: Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys 490: 103-109, 2009.
18. Choi S, Lim MH, Kim KM, Jeon BH, Song WO and Kim TW: Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. Toxicol Appl Pharmacol 257: 165-173, 2011.
19. Lee SJ, Moon GS, Jung KH, Kim WJ and Moon SK: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. Food Chem Toxicol 48: 277-283, 2010.
20. Jeong JW, Jin CY, Park C, et al: Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. Int J Oncol 40: 1697-1704, 2012.
21. Shi P, Huang Z, Tan X and Chen G: Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells. Methods Find Exp Clin Pharmacol 30: 347-353, 2008.
22. Wang BJ, Won SJ, Yu ZR and Su CL: Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. Food Chem Toxicol 43: 543-552, 2005.
23. Robertson JB, Williams JR and Little JB: Enhancement of radiation killing of cultured mammalian cells by cordycepin. Int J Radiat Biol Relat Stud Phys Chem Med 34: 417-429, 1978.
24. Wong YY, Moon A, Duffin R, et al: Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 285: 2610-2621, 2010.
25. Ni H, Zhou XH, Li HH and Huang WF: Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium. J Chromatogr B Analyt Technol Biomed Life Sci 877: 2135-2141, 2009.
26. Hansen MB, Nielsen SE and Berg K: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119: 203-210, 1989.
27. Telford WG, King LE and Fraker PJ: Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Cell Prolif 24: 447-459, 1991.
28. Xing YN, Liang HW, Zhao L and Xu HM: The antitumor activity of exogenous and endogenous canstatin on colorectal cancer cells. Asian Pac J Cancer Prev 12: 2713-2716, 2011.
29. Hu J and Verkman AS: Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J 20: 1892-1894, 2006.
30. Oikawa T, Sasaki T, Nakamura M, et al: The proteasome is involved in angiogenesis. Biochem Biophys Res Commun 246: 243-248, 1998.
31. Liu Z, Tao X, Zhang C, Lu Y and Wei D: Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide. Biomed Pharmacother 59: 481-490, 2005.
32. Chang W, Lim S, Song H, Song BW, Kim HJ, Cha MJ, Sung JM, Kim TW and Hwang KC: Cordycepin inhibits vascular smooth muscle cell proliferation. Eur J Pharmacol 597: 64-69, 2008.
33. Chen LS, Du-Cuny L, Vethantham V, et al: Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol 79: 669-677, 2010.
34. Nakamura K, Konoha K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K and Kunitomo M: Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo 19: 137-141, 2005.
35. Wu WC, Hsiao JR, Lian YY, Lin CY and Huang BM: The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line. Cancer Chemother Pharmacol 60: 103-111, 2007.
36. Thomadaki H, Scorilas A, Tsiapalis CM and Havredaki M: The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner. Cancer Chemother Pharmacol 61: 251-265, 2008.
37. Lee CW, Wong LL, Tse EY, et al: AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res 72: 4394-4404, 2012.
38. Guo P, Kai Q, Gao J, et al: Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharmacol Sci 113: 395-403, 2010.
39. Wu JY, Zhang QX and Leung PH: Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice. Phytomedicine 14: 43-49, 2007.
40. Zetter BR: Angiogenesis and tumor metastasis. Annu Rev Med 49: 407-424, 1998.
41. Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
42. Lu ZJ, Ren YQ, Wang GP, et al: Biological behaviors and proteomics analysis of hybrid cell line EAhy926 and its parent cell line A549. J Exp Clin Cancer Res 28: 16, 2009.
43. Nelson NJ: Angiogenesis research is on fast forward. J Natl Cancer Inst 91: 820-822, 1999.
44. Edgell CJ, Haizlip JE, Bagnell CR, et al: Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926. In Vitro Cell Dev Biol 26: 1167-1172, 1990.
45. Edgell CJ, McDonald CC and Graham JB: Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 80: 3734-3737, 1983.
46. Adamson RH, Zaharevitz DW and Johns DG: Enhancement of the biological activity of adenosine analogs by the adenosine deaminase inhibitor 2'-deoxycoformycin. Pharmacology 15: 84-89, 1977.
47. Farthing D, Sica D, Gehr T, et al: An HPLC method for determination of inosine and hypoxanthine in human plasma from healthy volunteers and patients presenting with potential acute cardiac ischemia. J Chromatogr B Analyt Technol Biomed Life Sci 854: 158-164, 2007.