Methods for measuring antibody-dependent cell-mediated cytotoxicity in vitro

Methods in Molecular Biology

Volumn 1134, Issue , 2014, Pages 59-65

  Miller, Aaron S ^a   Tejada, Max L ^a   Gazzano Santoro, Hélène ^a  

^a GENENTECH INC   (United States)

Author keywords

Cell death; Fc receptors; Interferon gamma; Natural killer cells; Tumor necrosis factor

Indexed keywords

GAMMA INTERFERON; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY BLOOD LEVEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOLOGICAL PROCEDURES; PRIORITY JOURNAL;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; HUMANS; KILLER CELLS, NATURAL;

EID: 84896274654     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-0326-9_5     Document Type: Article

References (10)

1. Janeway C (2005) Immunobiology: the immune system in health and disease, 6th edn. Garland Science, New York
2. Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, Xie D, Lai J, Stadlen A, Li B, Fox JA, Presta LG (2001) High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 276:6591-6604
3. Bryceson YT, March ME, Ljunggren HG, Long EO (2006) Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood 107:159-166
4. Clynes RA, Towers TL, Presta LG, Ravetch JV (2000) Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6:443-446
5. Dall'Ozzo S, Tartas S, Paintaud G, Cartron G, Colombat P, Bardos P, Watier H, Thibault G (2004) Rituximab-dependent cytotoxicity by natural killer cells: infl uence of FCGR3A polymorphism on the concentration-effect relationship. Cancer Res 64:4664-4669
6. Miller AS, Tejada ML, Gazzano-Santoro H (2012) Development of an ELISA based bridging assay as a surrogate measure of ADCC. J Immunol Methods 385:45-50
7. Schnueriger A, Grau R, Sondermann P, Schreitmueller T, Marti S, Zocher M (2011) Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies. Mol Immunol 48: 1512-1517
8. Tejada ML, Jia X, Gazzano-Santoro H (2013) Using cytokine release as a surrogate measure of antibody dependent cell-mediated cytotoxicity. mAbs (manuscript submitted for review)
9. Gong JH, Maki G, Klingemann HG (1994) Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia 8:652-658
10. Kornbluth J, Flomenberg N, Dupont B (1982) Cell surface phenotype of a cloned line of human natural killer cells. J Immunol 129:2831-2837