메뉴 건너뛰기




Volumn 5, Issue SUPPL.5, 2013, Pages

Chemotherapy advances in small-cell lung cancer

Author keywords

Amrubicin; Belotecan; Picoplatin; Relapsed SCLC; Small cell lung cancer (SCLC)

Indexed keywords

AMRUBICIN; BELOTECAN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; IFOSFAMIDE; IRINOTECAN; PICOPLATIN; PLACEBO; TOPOTECAN; VINCRISTINE;

EID: 84896264786     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2013.07.43     Document Type: Review
Times cited : (141)

References (107)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 5
    • 0014665977 scopus 로고
    • Five-year follow-up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus
    • Miller AB, Fox W, Tall R. Five-year follow-up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus. Lancet 1969;2:501-5.
    • (1969) Lancet , vol.2 , pp. 501-505
    • Miller, A.B.1    Fox, W.2    Tall, R.3
  • 6
    • 0014498661 scopus 로고
    • Alkylating agents in bronchogenic carcinoma
    • Green RA, Humphrey E, Close H, et al. Alkylating agents in bronchogenic carcinoma. Am J Med 1969;46:516-25.
    • (1969) Am J Med , vol.46 , pp. 516-525
    • Green, R.A.1    Humphrey, E.2    Close, H.3
  • 7
    • 0018728239 scopus 로고
    • The superiority of combination chemotherapy over single agent chemotherapy in small cell lung carcinoma
    • Lowenbraun S, Bartolucci A, Smalley RV, et al. The superiority of combination chemotherapy over single agent chemotherapy in small cell lung carcinoma. Cancer 1979;44:406-13.
    • (1979) Cancer , vol.44 , pp. 406-413
    • Lowenbraun, S.1    Bartolucci, A.2    Smalley, R.V.3
  • 8
    • 0017873236 scopus 로고
    • Small-cell carcinoma of the lung: combined chemotherapy and radiation: a Southwest Oncology Group study
    • Livingston RB, Moore TN, Heilbrun L, et al. Small-cell carcinoma of the lung: combined chemotherapy and radiation: a Southwest Oncology Group study. Ann Intern Med 1978;88:194-9.
    • (1978) Ann Intern Med , vol.88 , pp. 194-199
    • Livingston, R.B.1    Moore, T.N.2    Heilbrun, L.3
  • 10
    • 0032998171 scopus 로고    scopus 로고
    • Twenty years of phase III trials for patients with extensive-stage small-cell lung cancer: perceptible progress
    • Chute JP, Chen T, Feigal E, et al. Twenty years of phase III trials for patients with extensive-stage small-cell lung cancer: perceptible progress. J Clin Oncol 1999;17:1794-801.
    • (1999) J Clin Oncol , vol.17 , pp. 1794-1801
    • Chute, J.P.1    Chen, T.2    Feigal, E.3
  • 11
    • 37349068491 scopus 로고    scopus 로고
    • The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer
    • Shepherd FA, Crowley J, Van Houtte P, et al. The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. J Thorac Oncol 2007;2:1067-77.
    • (2007) J Thorac Oncol , vol.2 , pp. 1067-1077
    • Shepherd, F.A.1    Crowley, J.2    Van Houtte, P.3
  • 12
    • 80155191727 scopus 로고    scopus 로고
    • Australian Institute of Health and Welfare & Cancer Australia 2011, Cancer series no. 64. Canberra: AIHW
    • Australian Institute of Health and Welfare & Cancer Australia 2011. Lung cancer in Australia: an overview. Cancer series no. 64. Canberra: AIHW, 2011.
    • (2011) Lung cancer in Australia: an overview
  • 13
    • 0345062339 scopus 로고    scopus 로고
    • Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group
    • Aupérin A, Arriagada R, Pignon JP, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 1999;341:476-84.
    • (1999) N Engl J Med , vol.341 , pp. 476-484
    • Aupérin, A.1    Arriagada, R.2    Pignon, J.P.3
  • 14
    • 0015802663 scopus 로고
    • Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus
    • Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Ten-year follow-up. Lancet 1973;2:63-5.
    • (1973) Ten-year follow-up. Lancet , vol.2 , pp. 63-65
    • Fox, W.1    Scadding, J.G.2
  • 16
    • 84866324536 scopus 로고    scopus 로고
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
    • Byers LA, Wang J, Nilsson MB, et al. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov 2012;2:798-811.
    • (2012) Cancer Discov , vol.2 , pp. 798-811
    • Byers, L.A.1    Wang, J.2    Nilsson, M.B.3
  • 17
    • 84866343458 scopus 로고    scopus 로고
    • A genetic snapshot of small cell lung cancer
    • Rosell R, Wannesson L. A genetic snapshot of small cell lung cancer. Cancer Discov 2012;2:769-71.
    • (2012) Cancer Discov , vol.2 , pp. 769-771
    • Rosell, R.1    Wannesson, L.2
  • 18
    • 79959360314 scopus 로고    scopus 로고
    • History of small-cell lung cancer
    • Haddadin S, Perry MC. History of small-cell lung cancer. Clin Lung Cancer 2011;12:87-93.
    • (2011) Clin Lung Cancer , vol.12 , pp. 87-93
    • Haddadin, S.1    Perry, M.C.2
  • 19
    • 0001248220 scopus 로고
    • The nature of the "oat-celled sarcoma" of the mediastinum
    • Barnard WG. The nature of the "oat-celled sarcoma" of the mediastinum. J Pathol 1926;29:241-4.
    • (1926) J Pathol , vol.29 , pp. 241-244
    • Barnard, W.G.1
  • 20
    • 0015861452 scopus 로고
    • Keynote address on biostatistics and data retrieval
    • Zelen M. Keynote address on biostatistics and data retrieval. Cancer Chemother Rep 3 1973;4:31-42.
    • (1973) Cancer Chemother Rep 3 , vol.4 , pp. 31-42
    • Zelen, M.1
  • 21
    • 35548956927 scopus 로고    scopus 로고
    • Small cell lung cancer: have we made any progress over the last 25 years?
    • Lally BE, Urbanic JJ, Blackstock AW, et al. Small cell lung cancer: have we made any progress over the last 25 years? Oncologist 2007;12:1096-104.
    • (2007) Oncologist , vol.12 , pp. 1096-1104
    • Lally, B.E.1    Urbanic, J.J.2    Blackstock, A.W.3
  • 22
    • 0033400222 scopus 로고    scopus 로고
    • Management of small cell lung cancer: current state of the art
    • Johnson DH. Management of small cell lung cancer: current state of the art. Chest 1999;116:525S-530S.
    • (1999) Chest , vol.116
    • Johnson, D.H.1
  • 23
    • 0012154921 scopus 로고
    • Oat cell lung cancer
    • Watson WL, Berg JW. Oat cell lung cancer. Cancer 1962;15:759-68.
    • (1962) Cancer , vol.15 , pp. 759-768
    • Watson, W.L.1    Berg, J.W.2
  • 24
    • 33748743876 scopus 로고
    • The response of various types of bronchogenic carcinoma to nitrogen mustard
    • Levine B, Weisberger AS. The response of various types of bronchogenic carcinoma to nitrogen mustard. Ann Intern Med 1955;42:1089-96.
    • (1955) Ann Intern Med , vol.42 , pp. 1089-1096
    • Levine, B.1    Weisberger, A.S.2
  • 25
    • 0041145142 scopus 로고
    • Nitrogen mustard and the steroid hormones in the treatment of inoperable bronchogenic carcinoma
    • Wolf J, Spear P, Yesner R, et al. Nitrogen mustard and the steroid hormones in the treatment of inoperable bronchogenic carcinoma. Am J Med 1960;29:1008-16.
    • (1960) Am J Med , vol.29 , pp. 1008-1016
    • Wolf, J.1    Spear, P.2    Yesner, R.3
  • 26
    • 73649180549 scopus 로고
    • Evaluation of nitrogen mustard in prolonging life of patients with bronchogenic carcinoma
    • Wolf J, Yesner R, Patno ME. Evaluation of nitrogen mustard in prolonging life of patients with bronchogenic carcinoma. Cancer Chemother Rep 1962;16:473-5.
    • (1962) Cancer Chemother Rep , vol.16 , pp. 473-475
    • Wolf, J.1    Yesner, R.2    Patno, M.E.3
  • 27
    • 84966137845 scopus 로고
    • Radiotherapy alone or with chemotherapy in the treatment of small-cell carcinoma of the lung
    • Medical Research Council Lung Cancer Working Party.
    • Medical Research Council Lung Cancer Working Party. Radiotherapy alone or with chemotherapy in the treatment of small-cell carcinoma of the lung. Br J Cancer 1979;40:1-10.
    • (1979) Br J Cancer , vol.40 , pp. 1-10
  • 29
    • 0020451461 scopus 로고
    • Etoposide as single agent and in combination chemotherapy of bronchogenic carcinoma
    • Goldhirsch A, Joss R, Cavalli F, et al. Etoposide as single agent and in combination chemotherapy of bronchogenic carcinoma. Cancer Treat Rev 1982;9:85-90.
    • (1982) Cancer Treat Rev , vol.9 , pp. 85-90
    • Goldhirsch, A.1    Joss, R.2    Cavalli, F.3
  • 30
    • 0022409779 scopus 로고
    • VP-16 and cisplatin as first-line therapy for small-cell lung cancer
    • Evans WK, Shepherd FA, Feld R, et al. VP-16 and cisplatin as first-line therapy for small-cell lung cancer. J Clin Oncol 1985;3:1471-7.
    • (1985) J Clin Oncol , vol.3 , pp. 1471-1477
    • Evans, W.K.1    Shepherd, F.A.2    Feld, R.3
  • 31
    • 0022974515 scopus 로고
    • First-line therapy with VP-16 and cisplatin for small-cell lung cancer
    • Evans WK, Shepherd FA, Feld R, et al. First-line therapy with VP-16 and cisplatin for small-cell lung cancer. Semin Oncol 1986;13:17-23.
    • (1986) Semin Oncol , vol.13 , pp. 17-23
    • Evans, W.K.1    Shepherd, F.A.2    Feld, R.3
  • 33
    • 0018104018 scopus 로고
    • VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules
    • Cavalli F, Sonntag RW, Jungi F, et al. VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules. Cancer Treat Rep 1978;62:473-5.
    • (1978) Cancer Treat Rep , vol.62 , pp. 473-475
    • Cavalli, F.1    Sonntag, R.W.2    Jungi, F.3
  • 34
    • 0025141733 scopus 로고
    • Treatment of limited-stage smallcell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide: a randomized trial of the North Central Cancer Treatment Group
    • Jett JR, Everson L, Therneau TM, et al. Treatment of limited-stage smallcell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide: a randomized trial of the North Central Cancer Treatment Group. J Clin Oncol 1990;8:33-8.
    • (1990) J Clin Oncol , vol.8 , pp. 33-38
    • Jett, J.R.1    Everson, L.2    Therneau, T.M.3
  • 35
    • 0023933689 scopus 로고
    • Therapy of small cell lung cancer: a perspective on two decades of clinical research
    • Seifter EJ, Ihde DC. Therapy of small cell lung cancer: a perspective on two decades of clinical research. Semin Oncol 1988;15:278-99.
    • (1988) Semin Oncol , vol.15 , pp. 278-299
    • Seifter, E.J.1    Ihde, D.C.2
  • 36
    • 0026500785 scopus 로고
    • Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group
    • Roth BJ, Johnson DH, Einhorn LH, et al. Randomized study of cyclophosphamide, doxorubicin, and vincristine versus etoposide and cisplatin versus alternation of these two regimens in extensive small-cell lung cancer: a phase III trial of the Southeastern Cancer Study Group. J Clin Oncol 1992;10:282-91.
    • (1992) J Clin Oncol , vol.10 , pp. 282-291
    • Roth, B.J.1    Johnson, D.H.2    Einhorn, L.H.3
  • 37
    • 0025898914 scopus 로고
    • Randomized trial of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small-cell lung cancer
    • Fukuoka M, Furuse K, Saijo N, et al. Randomized t r i a l of cyclophosphamide, doxorubicin, and vincristine versus cisplatin and etoposide versus alternation of these regimens in small-cell lung cancer. J Natl Cancer Inst 1991;83:855-61.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 855-861
    • Fukuoka, M.1    Furuse, K.2    Saijo, N.3
  • 38
    • 0037115426 scopus 로고    scopus 로고
    • Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years' follow-up
    • Sundstrøm S, Bremnes RM, Kaasa S, et al. Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years' follow-up. J Clin Oncol 2002;20:4665-72.
    • (2002) J Clin Oncol , vol.20 , pp. 4665-4672
    • Sundstrøm, S.1    Bremnes, R.M.2    Kaasa, S.3
  • 39
    • 9244239693 scopus 로고    scopus 로고
    • Etoposide-cisplatin and thoracic radiation therapy salvage of incomplete responders to a noncisplatin induction regimen for limited and extensive small-cell carcinoma of the lung
    • Shaw EG, Frytak S, Eagan RT, et al. Etoposide-cisplatin and thoracic radiation therapy salvage of incomplete responders to a noncisplatin induction regimen for limited and extensive small-cell carcinoma of the lung. Am J Clin Oncol 1996;19:154-8.
    • (1996) Am J Clin Oncol , vol.19 , pp. 154-158
    • Shaw, E.G.1    Frytak, S.2    Eagan, R.T.3
  • 40
    • 0027992052 scopus 로고
    • Randomized comparison of etoposide-cisplatin vs. etoposide-carboplatin and irradiation in small-cell lung cancer. A Hellenic Co-operative Oncology Group study
    • Skarlos DV, Samantas E, Kosmidis P, et al. Randomized comparison of etoposide-cisplatin vs. etoposide-carboplatin and irradiation in small-cell lung cancer. A Hellenic Co-operative Oncology Group study. Ann Oncol 1994;5:601-7.
    • (1994) Ann Oncol , vol.5 , pp. 601-607
    • Skarlos, D.V.1    Samantas, E.2    Kosmidis, P.3
  • 41
    • 0034129381 scopus 로고    scopus 로고
    • Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen without this alkylating agent
    • Pujol JL, Carestia L, Daurès JP. Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen without this alkylating agent. Br J Cancer 2000;83:8-15.
    • (2000) Br J Cancer , vol.83 , pp. 8-15
    • Pujol, J.L.1    Carestia, L.2    Daurès, J.P.3
  • 42
    • 84863752868 scopus 로고    scopus 로고
    • Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data
    • Rossi A, Di Maio M, Chiodini P, et al. Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data. J Clin Oncol 2012;30:1692-8.
    • (2012) J Clin Oncol , vol.30 , pp. 1692-1698
    • Rossi, A.1    Di Maio, M.2    Chiodini, P.3
  • 43
    • 0037050354 scopus 로고    scopus 로고
    • Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer
    • Noda K, Nishiwaki Y, Kawahara M, et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med 2002;346:85-91.
    • (2002) N Engl J Med , vol.346 , pp. 85-91
    • Noda, K.1    Nishiwaki, Y.2    Kawahara, M.3
  • 44
    • 33646447066 scopus 로고    scopus 로고
    • Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer
    • Hanna N, Bunn PA Jr, Langer C, et al. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol 2006;24:2038-43.
    • (2006) J Clin Oncol , vol.24 , pp. 2038-2043
    • Hanna, N.1    Bunn Jr., P.A.2    Langer, C.3
  • 45
    • 66349102227 scopus 로고    scopus 로고
    • Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124
    • Lara PN Jr, Natale R, Crowley J, et al. Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol 2009;27:2530-5.
    • (2009) J Clin Oncol , vol.27 , pp. 2530-2535
    • Lara Jr., P.N.1    Natale, R.2    Crowley, J.3
  • 46
    • 77952548297 scopus 로고    scopus 로고
    • A multicenter phase II study of belotecan, new camptothecin analogue, in patients with previously untreated extensive stage disease small cell lung cancer
    • Kim SJ, Kim JS, Kim SC, et al. A multicenter phase II study of belotecan, new camptothecin analogue, in patients with previously untreated extensive stage disease small cell lung cancer. Lung Cancer 2010;68:446-9.
    • (2010) Lung Cancer , vol.68 , pp. 446-449
    • Kim, S.J.1    Kim, J.S.2    Kim, S.C.3
  • 47
    • 84856700926 scopus 로고    scopus 로고
    • Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer
    • Hong J, Jung M, Kim YJ, et al. Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer. Cancer Chemother Pharmacol 2012;69:215-20.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 215-220
    • Hong, J.1    Jung, M.2    Kim, Y.J.3
  • 48
    • 84877111917 scopus 로고    scopus 로고
    • Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer
    • Lim S, Cho BC, Jung JY, et al. Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer. Lung Cancer 2013;80:313-8.
    • (2013) Lung Cancer , vol.80 , pp. 313-318
    • Lim, S.1    Cho, B.C.2    Jung, J.Y.3
  • 49
    • 20144387229 scopus 로고    scopus 로고
    • Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer
    • Ohe Y, Negoro S, Matsui K, et al. Phase I-II study of amrubicin and cisplatin in previously untreated patients with extensive-stage small-cell lung cancer. Ann Oncol 2005;16:430-6.
    • (2005) Ann Oncol , vol.16 , pp. 430-436
    • Ohe, Y.1    Negoro, S.2    Matsui, K.3
  • 50
    • 34248670669 scopus 로고    scopus 로고
    • Phase II study of amrubicin in previously untreated patients with extensive-disease small cell lung cancer: West Japan Thoracic Oncology Group (WJTOG) study
    • Yana T, Negoro S, Takada M, et al. Phase II study of amrubicin in previously untreated patients with extensive-disease small cell lung cancer: West Japan Thoracic Oncology Group (WJTOG) study. Invest New Drugs 2007;25:253-8.
    • (2007) Invest New Drugs , vol.25 , pp. 253-258
    • Yana, T.1    Negoro, S.2    Takada, M.3
  • 51
    • 77954426507 scopus 로고    scopus 로고
    • Phase II study of sequential triplet chemotherapy, irinotecan and cisplatin followed by amrubicin, in patients with extensive-stage small cell lung cancer: West Japan Thoracic Oncology Group Study 0301
    • Kobayashi M, Matsui K, Iwamoto Y, et al. Phase II study of sequential triplet chemotherapy, irinotecan and cisplatin followed by amrubicin, in patients with extensive-stage small cell lung cancer: West Japan Thoracic Oncology Group Study 0301. J Thorac Oncol 2010;5:1075-80.
    • (2010) J Thorac Oncol , vol.5 , pp. 1075-1080
    • Kobayashi, M.1    Matsui, K.2    Iwamoto, Y.3
  • 52
    • 80053364022 scopus 로고    scopus 로고
    • Randomised phase II study of amrubicin as single agent or in combination with cisplatin versus cisplatin etoposide as first-line treatment in patients with extensive stage small cell lung cancer-EORTC 08062
    • O'Brien ME, Konopa K, Lorigan P, et al. Randomised phase II study of amrubicin as single agent or in combination with cisplatin versus cisplatin etoposide as first-line treatment in patients with extensive stage small cell lung cancer-EORTC 08062. Eur J Cancer 2011;47:2322-30.
    • (2011) Eur J Cancer , vol.47 , pp. 2322-2330
    • O'Brien, M.E.1    Konopa, K.2    Lorigan, P.3
  • 53
    • 79958061953 scopus 로고    scopus 로고
    • Review of the management of relapsed smallcell lung cancer with amrubicin hydrochloride
    • Kimura T, Kudoh S, Hirata K. Review of the management of relapsed smallcell lung cancer with amrubicin hydrochloride. Clin Med Insights Oncol 2011;5:23-34.
    • (2011) Clin Med Insights Oncol , vol.5 , pp. 23-34
    • Kimura, T.1    Kudoh, S.2    Hirata, K.3
  • 54
    • 71649090072 scopus 로고    scopus 로고
    • Chonnam National University Hospital. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2013 July 9]. Available online:
    • Chonnam National University Hospital. Trial of belotecan/cisplatin in chemotherapy naive small cell lung cancer patient (COMBAT). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2013 July 9]. Available online: http://clinicaltrials.gov/show/NCT00826644
    • Trial of belotecan/cisplatin in chemotherapy naive small cell lung cancer patient (COMBAT)
  • 55
    • 0032445062 scopus 로고    scopus 로고
    • A new antitumor agent amrubicin induces cell growth inhibition by stabilizing topoisomerase IIDNA complex
    • Hanada M, Mizuno S, Fukushima A, et al. A new antitumor agent amrubicin induces cell growth inhibition by stabilizing topoisomerase IIDNA complex. Jpn J Cancer Res 1998;89:1229-38.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1229-1238
    • Hanada, M.1    Mizuno, S.2    Fukushima, A.3
  • 56
  • 57
    • 84859987036 scopus 로고    scopus 로고
    • Long-term amrubicin chemotherapy for small-cell lung cancer
    • Higashiguchi M, Suzuki H, Hirashima T, et al. Long-term amrubicin chemotherapy for small-cell lung cancer. Anticancer Res 2012;32:1423-7.
    • (2012) Anticancer Res , vol.32 , pp. 1423-1427
    • Higashiguchi, M.1    Suzuki, H.2    Hirashima, T.3
  • 58
    • 0026482388 scopus 로고
    • A meta-analysis of thoracic radiotherapy for small-cell lung cancer
    • Pignon JP, Arriagada R, Ihde DC, et al. A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 1992;327:1618-24.
    • (1992) N Engl J Med , vol.327 , pp. 1618-1624
    • Pignon, J.P.1    Arriagada, R.2    Ihde, D.C.3
  • 59
    • 84875884949 scopus 로고    scopus 로고
    • Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer
    • Noro R, Yoshimura A, Yamamoto K, et al. Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer. Anticancer Res 2013;33:1117-23.
    • (2013) Anticancer Res , vol.33 , pp. 1117-1123
    • Noro, R.1    Yoshimura, A.2    Yamamoto, K.3
  • 60
    • 84904768787 scopus 로고    scopus 로고
    • Sumitomo Pharmaceutical (Suzhou) Co., Ltd. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2013 July 10]. Available online.
    • Sumitomo Pharmaceutical (Suzhou) Co., Ltd. Phase 3 study of amrubicin with cisplatin versus etoposide-cisplatin for extensive disease small cell lung cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2013 July 10]. Available online: http:// clinicaltrials.gov/ct2/show/NCT00660504
    • Phase 3 study of amrubicin with cisplatin versus etoposide-cisplatin for extensive disease small cell lung cancer
  • 61
    • 0035871527 scopus 로고    scopus 로고
    • Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593- -a phase III trial of the Eastern Cooperative Oncology Group
    • Schiller JH, Adak S, Cella D, et al. Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593- -a phase III trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2001;19:2114-22.
    • (2001) J Clin Oncol , vol.19 , pp. 2114-2122
    • Schiller, J.H.1    Adak, S.2    Cella, D.3
  • 62
    • 77957020019 scopus 로고    scopus 로고
    • Maintenance or consolidation therapy in small-cell lung cancer: a systematic review and meta-analysis
    • Rossi A, Garassino MC, Cinquini M, et al. Maintenance or consolidation therapy in small-cell lung cancer: a systematic review and meta-analysis. Lung Cancer 2010;70:119-28.
    • (2010) Lung Cancer , vol.70 , pp. 119-128
    • Rossi, A.1    Garassino, M.C.2    Cinquini, M.3
  • 64
    • 0023677771 scopus 로고
    • Teniposide in the treatment of small-cell lung cancer: the influence of prior chemotherapy
    • Giaccone G, Donadio M, Bonardi G, et al. Teniposide in the treatment of small-cell lung cancer: the influence of prior chemotherapy. J Clin Oncol 1988;6:1264-70.
    • (1988) J Clin Oncol , vol.6 , pp. 1264-1270
    • Giaccone, G.1    Donadio, M.2    Bonardi, G.3
  • 65
    • 0023519996 scopus 로고
    • Retreatment with the induction regimen in small cell lung cancer relapsing after an initial response to short term chemotherapy
    • Postmus PE, Berendsen HH, van Zandwijk N, et al. Retreatment with the induction regimen in small cell lung cancer relapsing after an initial response to short term chemotherapy. Eur J Cancer Clin Oncol 1987;23:1409-11.
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1409-1411
    • Postmus, P.E.1    Berendsen, H.H.2    van Zandwijk, N.3
  • 66
  • 67
    • 0037330778 scopus 로고    scopus 로고
    • Recurrent small cell lung cancer: update
    • Glisson BS. Recurrent small cell lung cancer: update. Semin Oncol 2003;30:72-8.
    • (2003) Semin Oncol , vol.30 , pp. 72-78
    • Glisson, B.S.1
  • 68
    • 0033044111 scopus 로고    scopus 로고
    • Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer
    • von Pawel J, Schiller JH, Shepherd FA, et al. Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. J Clin Oncol 1999;17:658-67.
    • (1999) J Clin Oncol , vol.17 , pp. 658-667
    • von Pawel, J.1    Schiller, J.H.2    Shepherd, F.A.3
  • 69
    • 34247218552 scopus 로고    scopus 로고
    • Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer
    • O'Brien ME, Ciuleanu TE, Tsekov H, et al. Phase III trial comparing supportive care alone with supportive care with oral topotecan in patients with relapsed small-cell lung cancer. J Clin Oncol 2006;24:5441-7.
    • (2006) J Clin Oncol , vol.24 , pp. 5441-5447
    • O'Brien, M.E.1    Ciuleanu, T.E.2    Tsekov, H.3
  • 70
    • 34249941781 scopus 로고    scopus 로고
    • Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer
    • Eckardt JR, von Pawel J, Pujol JL, et al. Phase III study of oral compared with intravenous topotecan as second-line therapy in small-cell lung cancer. J Clin Oncol 2007;25:2086-92.
    • (2007) J Clin Oncol , vol.25 , pp. 2086-2092
    • Eckardt, J.R.1    von Pawel, J.2    Pujol, J.L.3
  • 71
    • 0031985696 scopus 로고    scopus 로고
    • A phase II study of paclitaxel in heavily pretreated patients with small-cell lung cancer
    • Smit EF, Fokkema E, Biesma B, et al. A phase II study of paclitaxel in heavily pretreated patients with small-cell lung cancer. Br J Cancer 1998;77:347-51.
    • (1998) Br J Cancer , vol.77 , pp. 347-351
    • Smit, E.F.1    Fokkema, E.2    Biesma, B.3
  • 72
    • 0026680292 scopus 로고
    • CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer
    • Masuda N, Fukuoka M, Kusunoki Y, et al. CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer. J Clin Oncol 1992;10:1225-9.
    • (1992) J Clin Oncol , vol.10 , pp. 1225-1229
    • Masuda, N.1    Fukuoka, M.2    Kusunoki, Y.3
  • 73
    • 0037504528 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine in refractory or relapsed small-cell lung cancer: Eastern Cooperative Oncology Group Trial 1597
    • Masters GA, Declerck L, Blanke C, et al. Phase II trial of gemcitabine in refractory or relapsed small-cell lung cancer: Eastern Cooperative Oncology Group Trial 1597. J Clin Oncol 2003;21:1550-5.
    • (2003) J Clin Oncol , vol.21 , pp. 1550-1555
    • Masters, G.A.1    Declerck, L.2    Blanke, C.3
  • 74
    • 13344270908 scopus 로고    scopus 로고
    • Phase II study of vinorelbine in heavily previously treated small cell lung cancer. Japan Lung Cancer Vinorelbine Study Group
    • Furuse K, Kubota K, Kawahara M, et al. Phase II study of vinorelbine in heavily previously treated small cell lung cancer. Japan Lung Cancer Vinorelbine Study Group. Oncology 1996;53:169-72.
    • (1996) Oncology , vol.53 , pp. 169-172
    • Furuse, K.1    Kubota, K.2    Kawahara, M.3
  • 75
    • 4344560978 scopus 로고    scopus 로고
    • Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer
    • Goto K, Sekine I, Nishiwaki Y, et al. Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer. Br J Cancer 2004;91:659-65.
    • (2004) Br J Cancer , vol.91 , pp. 659-665
    • Goto, K.1    Sekine, I.2    Nishiwaki, Y.3
  • 76
    • 0033835465 scopus 로고    scopus 로고
    • Combination of cisplatin, ifosfamide, and irinotecan with rhG-CSF support for the treatment of refractory or relapsed small-cell lung cancer
    • Fujita A, Takabatake H, Tagaki S, et al. Combination of cisplatin, ifosfamide, and irinotecan with rhG-CSF support for the treatment of refractory or relapsed small-cell lung cancer. Oncology 2000;59:105-9.
    • (2000) Oncology , vol.59 , pp. 105-109
    • Fujita, A.1    Takabatake, H.2    Tagaki, S.3
  • 77
    • 0033044211 scopus 로고    scopus 로고
    • Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule
    • Groen HJ, Fokkema E, Biesma B, et al. Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule. J Clin Oncol 1999;17:927-32.
    • (1999) J Clin Oncol , vol.17 , pp. 927-932
    • Groen, H.J.1    Fokkema, E.2    Biesma, B.3
  • 78
    • 79955473109 scopus 로고    scopus 로고
    • Outcomes of small-cell lung cancer patients treated with second-line chemotherapy: a multiinstitutional retrospective analysis
    • Garassino MC, Torri V, Michetti G, et al. Outcomes of small-cell lung cancer patients treated with second-line chemotherapy: a multiinstitutional retrospective analysis. Lung Cancer 2011;72:378-83.
    • (2011) Lung Cancer , vol.72 , pp. 378-383
    • Garassino, M.C.1    Torri, V.2    Michetti, G.3
  • 79
    • 34247197121 scopus 로고    scopus 로고
    • Phase II trial of amrubicin for treatment of refractory or relapsed small-cell lung cancer: Thoracic Oncology Research Group Study 0301
    • Onoda S, Masuda N, Seto T, et al. Phase II trial of amrubicin for treatment of refractory or relapsed small-cell lung cancer: Thoracic Oncology Research Group Study 0301. J Clin Oncol 2006;24:5448-53.
    • (2006) J Clin Oncol , vol.24 , pp. 5448-5453
    • Onoda, S.1    Masuda, N.2    Seto, T.3
  • 80
    • 56749131841 scopus 로고    scopus 로고
    • Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402
    • Inoue A, Sugawara S, Yamazaki K, et al. Randomized phase II trial comparing amrubicin with topotecan in patients with previously treated small-cell lung cancer: North Japan Lung Cancer Study Group Trial 0402. J Clin Oncol 2008;26:5401-6.
    • (2008) J Clin Oncol , vol.26 , pp. 5401-5406
    • Inoue, A.1    Sugawara, S.2    Yamazaki, K.3
  • 81
    • 77956396425 scopus 로고    scopus 로고
    • Phase II study of amrubicin as secondline therapy in patients with platinum-refractory small-cell lung cancer
    • Ettinger DS, Jotte R, Lorigan P, et al. Phase II study of amrubicin as secondline therapy in patients with platinum-refractory small-cell lung cancer. J Clin Oncol 2010;28:2598-603.
    • (2010) J Clin Oncol , vol.28 , pp. 2598-2603
    • Ettinger, D.S.1    Jotte, R.2    Lorigan, P.3
  • 82
    • 79951993031 scopus 로고    scopus 로고
    • Randomized phase II trial of singleagent amrubicin or topotecan as second-line treatment in patients with small-cell lung cancer sensitive to first-line platinum-based chemotherapy
    • Jotte R, Conkling P, Reynolds C, et al. Randomized phase II trial of singleagent amrubicin or topotecan as second-line treatment in patients with small-cell lung cancer sensitive to first-line platinum-based chemotherapy. J Clin Oncol 2011;29:287-93.
    • (2011) J Clin Oncol , vol.29 , pp. 287-293
    • Jotte, R.1    Conkling, P.2    Reynolds, C.3
  • 83
    • 84904726722 scopus 로고    scopus 로고
    • Randomized phase 3 trial of amrubicin versus topotecan as second-line treatment for small cell lung cancer (SCLC)
    • abstr 7000
    • Von Pawel J, Jotte R, Spigel DR, et al. Randomized phase 3 trial of amrubicin versus topotecan as second-line treatment for small cell lung cancer (SCLC). J Clin Oncol 2011;29:abstr 7000.
    • (2011) J Clin Oncol , vol.29
    • Von Pawel, J.1    Jotte, R.2    Spigel, D.R.3
  • 84
    • 0036983552 scopus 로고    scopus 로고
    • ZD0473 treatment in lung cancer: an overview of the clinical trial results
    • Treat J, Schiller J, Quoix E, et al. ZD0473 treatment in lung cancer: an overview of the clinical trial results. Eur J Cancer 2002; 38 Suppl 8:S13-8.
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 8
    • Treat, J.1    Schiller, J.2    Quoix, E.3
  • 85
    • 65349157711 scopus 로고    scopus 로고
    • Phase II study of picoplatin as second-line therapy for patients with small-cell lung cancer
    • Eckardt JR, Bentsion DL, Lipatov ON, et al. Phase II study of picoplatin as second-line therapy for patients with small-cell lung cancer. J Clin Oncol 2009;27:2046-51.
    • (2009) J Clin Oncol , vol.27 , pp. 2046-2051
    • Eckardt, J.R.1    Bentsion, D.L.2    Lipatov, O.N.3
  • 86
    • 78049366860 scopus 로고    scopus 로고
    • Randomized phase III study (SPEAR) of picoplatin plus best supportive care (BSC) or BSC alone in patients (pts) with SCLC refractory or progressive within 6 months after first-line platinum-based chemotherapy
    • abstr 7002
    • Ciuleanu T, Samarzjia M, Demidchik Y, et al. Randomized phase III study (SPEAR) of picoplatin plus best supportive care (BSC) or BSC alone in patients (pts) with SCLC refractory or progressive within 6 months after first-line platinum-based chemotherapy. J Clin Oncol 2010;28:abstr 7002.
    • (2010) J Clin Oncol , vol.28
    • Ciuleanu, T.1    Samarzjia, M.2    Demidchik, Y.3
  • 87
    • 79952192731 scopus 로고    scopus 로고
    • A multicenter phase II study of belotecan, a new camptothecin analogue, as a second-line therapy in patients with small cell lung cancer
    • Rhee CK, Lee SH, Kim JS, et al. A multicenter phase II study of belotecan, a new camptothecin analogue, as a second-line therapy in patients with small cell lung cancer. Lung Cancer 2011;72:64-7.
    • (2011) Lung Cancer , vol.72 , pp. 64-67
    • Rhee, C.K.1    Lee, S.H.2    Kim, J.S.3
  • 88
    • 77956185923 scopus 로고    scopus 로고
    • Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: a phase II trial
    • Jeong J, Cho BC, Sohn JH, et al. Belotecan for relapsing small-cell lung cancer patients initially treated with an irinotecan-containing chemotherapy: a phase II trial. Lung Cancer 2010;70:77-81.
    • (2010) Lung Cancer , vol.70 , pp. 77-81
    • Jeong, J.1    Cho, B.C.2    Sohn, J.H.3
  • 89
    • 84863344528 scopus 로고    scopus 로고
    • Efficacy and toxicity of belotecan for relapsed or refractory small cell lung cancer patients
    • Kim GM, Kim YS, Ae Kang Y, et al. Efficacy and toxicity of belotecan for relapsed or refractory small cell lung cancer patients. J Thorac Oncol 2012;7:731-6.
    • (2012) J Thorac Oncol , vol.7 , pp. 731-736
    • Kim, G.M.1    Kim, Y.S.2    Ae Kang, Y.3
  • 90
    • 33845991547 scopus 로고    scopus 로고
    • Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients
    • Schmittel A, Knödler M, Hortig P, et al. Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients. Lung Cancer 2007;55:109-13.
    • (2007) Lung Cancer , vol.55 , pp. 109-113
    • Schmittel, A.1    Knödler, M.2    Hortig, P.3
  • 91
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 92
    • 34247116890 scopus 로고    scopus 로고
    • Amrubicin for the treatment of small cell lung cancer: does effectiveness cross the Pacific?
    • Ettinger DS. Amrubicin for the treatment of small cell lung cancer: does effectiveness cross the Pacific? J Thorac Oncol 2007;2:160-5.
    • (2007) J Thorac Oncol , vol.2 , pp. 160-165
    • Ettinger, D.S.1
  • 93
    • 33745594550 scopus 로고    scopus 로고
    • A phase I and pharmacological study of amrubicin and topotecan in patients of small-cell lung cancer with relapsed or extensive-disease small-cell lung cancer
    • Shibayama T, Hotta K, Takigawa N, et al. A phase I and pharmacological study of amrubicin and topotecan in patients of small-cell lung cancer with relapsed or extensive-disease small-cell lung cancer. Lung Cancer 2006;53:189-95.
    • (2006) Lung Cancer , vol.53 , pp. 189-195
    • Shibayama, T.1    Hotta, K.2    Takigawa, N.3
  • 94
    • 80052577998 scopus 로고    scopus 로고
    • A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensivedisease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401
    • Nogami N, Hotta K, Kuyama S, et al. A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensivedisease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401. Lung Cancer 2011;74:80-4.
    • (2011) Lung Cancer , vol.74 , pp. 80-84
    • Nogami, N.1    Hotta, K.2    Kuyama, S.3
  • 95
    • 0031962973 scopus 로고    scopus 로고
    • In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473
    • Holford J, Sharp SY, Murrer BA, et al. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br J Cancer 1998;77:366-73.
    • (1998) Br J Cancer , vol.77 , pp. 366-373
    • Holford, J.1    Sharp, S.Y.2    Murrer, B.A.3
  • 96
    • 80053562740 scopus 로고    scopus 로고
    • Novel strategies for the treatment of small-cell lung carcinoma
    • William WN Jr, Glisson BS. Novel strategies for the treatment of small-cell lung carcinoma. Nat Rev Clin Oncol 2011;8:611-9.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 611-619
    • William Jr., W.N.1    Glisson, B.S.2
  • 97
    • 0025816320 scopus 로고
    • The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines
    • Mistry P, Kelland LR, Abel G, et al. The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer 1991;64:215-20.
    • (1991) Br J Cancer , vol.64 , pp. 215-220
    • Mistry, P.1    Kelland, L.R.2    Abel, G.3
  • 98
    • 79959605918 scopus 로고    scopus 로고
    • Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin
    • Tang CH, Parham C, Shocron E, et al. Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin. Cancer Chemother Pharmacol 2011;67:1389-400.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 1389-1400
    • Tang, C.H.1    Parham, C.2    Shocron, E.3
  • 99
    • 34247863880 scopus 로고    scopus 로고
    • Phase II trial with carboplatin and bendamustine in patients with extensive stage small-cell lung cancer
    • Köster W, Heider A, Niederle N, et al. Phase II trial with carboplatin and bendamustine in patients with extensive stage small-cell lung cancer. J Thorac Oncol 2007;2:312-6.
    • (2007) J Thorac Oncol , vol.2 , pp. 312-316
    • Köster, W.1    Heider, A.2    Niederle, N.3
  • 100
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapynaive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapynaive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-51.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    von Pawel, J.3
  • 101
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636-44.
    • (2003) J Clin Oncol , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 102
    • 58949083363 scopus 로고    scopus 로고
    • Pemetrexed in relapsed smallcell lung cancer and the impact of shortened vitamin supplementation leadin time: results of a phase II trial
    • Socinski MA, Raju RN, Neubauer M, et al. Pemetrexed in relapsed smallcell lung cancer and the impact of shortened vitamin supplementation leadin time: results of a phase II trial. J Thorac Oncol 2008;3:1308-16.
    • (2008) J Thorac Oncol , vol.3 , pp. 1308-1316
    • Socinski, M.A.1    Raju, R.N.2    Neubauer, M.3
  • 103
    • 61549083739 scopus 로고    scopus 로고
    • Pemetrexed in second line and beyond small cell lung cancer: a Hoosier Oncology Group phase II study
    • Jalal S, Ansari R, Govindan R, et al. Pemetrexed in second line and beyond small cell lung cancer: a Hoosier Oncology Group phase II study. J Thorac Oncol 2009;4:93-6.
    • (2009) J Thorac Oncol , vol.4 , pp. 93-96
    • Jalal, S.1    Ansari, R.2    Govindan, R.3
  • 104
    • 33749587054 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    • Ceppi P, Volante M, Saviozzi S, et al. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006;107:1589-96.
    • (2006) Cancer , vol.107 , pp. 1589-1596
    • Ceppi, P.1    Volante, M.2    Saviozzi, S.3
  • 105
    • 84880916275 scopus 로고    scopus 로고
    • Thymidylate Synthase Expression and Outcome of Patients Receiving Pemetrexed for Advanced Nonsquamous Non-Small-Cell Lung Cancer in a Prospective Blinded Assessment Phase II Clinical Trial
    • Nicolson MC, Fennell DA, Ferry D, et al. Thymidylate Synthase Expression and Outcome of Patients Receiving Pemetrexed for Advanced Nonsquamous Non-Small-Cell Lung Cancer in a Prospective Blinded Assessment Phase II Clinical Trial. J Thorac Oncol 2013;8:930-939.
    • (2013) J Thorac Oncol , vol.8 , pp. 930-939
    • Nicolson, M.C.1    Fennell, D.A.2    Ferry, D.3
  • 106
    • 77954117079 scopus 로고    scopus 로고
    • High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes
    • Ibe T, Shimizu K, Nakano T, et al. High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes. J Surg Oncol 2010;102:11-7.
    • (2010) J Surg Oncol , vol.102 , pp. 11-17
    • Ibe, T.1    Shimizu, K.2    Nakano, T.3
  • 107
    • 73349084270 scopus 로고    scopus 로고
    • Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung
    • Monica V, Scagliotti GV, Ceppi P, et al. Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung. Clin Cancer Res 2009;15:7547-7552.
    • (2009) Clin Cancer Res , vol.15 , pp. 7547-7552
    • Monica, V.1    Scagliotti, G.V.2    Ceppi, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.