Efficacy and safety of weight-adjusted heparin prophylaxis for the prevention of acute venous thromboembolism among obese patients undergoing bariatric surgery: A systematic review and meta-analysis

Thrombosis Research

Volumn 133, Issue 4, 2014, Pages 682-687

  Ikesaka, Rick ^a   Delluc, Aurélien ^c   Le Gal, Grégoire ^a,b   Carrier, Marc ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

Author keywords

Bariatric surgery; Hemorrhage; Heparin; Low molecular weight; Mortality; Venous thromboembolism

Indexed keywords

ENOXAPARIN; FONDAPARINUX; HEPARIN; HEPARIN DERIVATIVE; NADROPARIN; PLACEBO;

ACUTE DISEASE; ARTICLE; BARIATRIC SURGERY; BLEEDING; DRUG EFFICACY; DRUG SAFETY; HUMAN; META ANALYSIS; OBESITY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM; BLOOD; CHEMICALLY INDUCED; COHORT ANALYSIS; PREVALENCE;

ACUTE DISEASE; BARIATRIC SURGERY; COHORT STUDIES; HEMORRHAGE; HEPARIN; HUMANS; OBESITY; PREVALENCE; VENOUS THROMBOEMBOLISM;

EID: 84896122370     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.01.021     Document Type: Article

References (17)

1. K.M. Flegal, M.D. Carroll, C.L. Ogden, and L.R. Curtin Prevalence and trends in obesity among US adults, 1999-2008 JAMA 303 3 2010 235 241
2. P.D. Stein Obesity as a risk factor in venous thromboembolism Am J Med 118 9 2005 978 980
3. W.H. Geerts, D. Bergqvist, G.F. Pineo, J.A. Heit, C.M. Samama, and M.R. Lassen et al. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th ed.) 6 Suppl. 6 2008 American College of Chest Physicians United States 381S 453S [cited 133 (Geerts) Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE= reference&D=emed8&NEWS=N&AN=2008310003 ]
4. J.A. Heit, M.D. Silverstein, D.N. Mohr, T.M. Petterson, W.M. O'Fallon, and L.J. Melton III Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study Arch Intern Med 160 6 Mar 27 2000 809 815
5. P.D. Stein, and F. Matta Pulmonary embolism and deep venous thrombosis following bariatric surgery Obes Surg 23 5 May 2013 663 668
6. M.K. Gould, D.A. Garcia, S.M. Wren, P.J. Karanicolas, J.I. Arcelus, and J.A. Heit et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 141 2 Suppl. Feb 2012 e227S e277S
7. R. Jain, S.M. Chung, L. Jain, M. Khurana, S.W. Lau, and J.E. Lee et al. Implications of obesity for drug therapy: limitations and challenges Clin Pharmacol Ther 90 1 Jul 2011 77 89
8. S.G. Frederiksen, J.L. Hedenbro, and L. Norgren Enoxaparin effect depends on body-weight and current doses may be inadequate in obese patients 5 2003 John Wiley and Sons Ltd. United Kingdom 547 548 [cited 90 (Frederiksen, Hedenbro) Department of Surgery, Lund University Hospital, Lund, Sweden, Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE= reference&D=emed6&NEWS=N&AN=2003200136 ]
9. J. Fareed, D. Hoppensteadt, J. Walenga, O. Iqbal, Q. Ma, and W. Jeske et al. Pharmacodynamic and pharmacokinetic properties of enoxaparin: implications for clinical practice Clin Pharmacokinet 42 12 2003 1043 1057
10. S. Schulman, and C. Kearon Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients J Thromb Haemost 3 4 Apr 2005 692 694
11. J.P. Higgins, D.G. Altman, P.C. Gotzsche, P. Juni, D. Moher, and A.D. Oxman et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials BMJ 343 2011 d5928
12. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 11 Jun 15 2002 1539 1558
13. M.F. Shepherd, T.K. Rosborough, and M.L. Schwartz Heparin thromboprophylaxis in gastric bypass surgery 2 2003 FD Communications Inc. United States 249 253 [cited 13 (Shepherd, Rosborough) Medical Education Department, Abbott Northwestern Hospital, Minneapolis, MN, United States, Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE= reference&D=emed6&NEWS=N&AN=2003210895 ]
14. N. Kucher, A. Leizorovicz, P.T. Vaitkus, A.T. Cohen, A.G.G. Turpie, and C.G. Olsson et al. Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or elderly hospitalized patients: A subgroup analysis of the PREVENT trial 3 2005 American Medical Association United States 341 345 [cited 165 (Vaitkus) Pharmacia Corp., Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed7&NEWS= N&AN=2005072188 ]
15. H.D. Woo, and Y.J. Kim Prevention of venous thromboembolism with enoxaparin in bariatirc surgery J Korean Surg Soc 84 5 May 2013 298 303
16. N.J. Birkmeyer, J.F. Finks, A.M. Carlin, D.L. Chengelis, K.R. Krause, and A.A. Hawasli et al. Comparative effectiveness of unfractionated and low-molecular-weight heparin for prevention of venous thromboembolism following bariatric surgery Arch Surg 147 11 Nov 1 2012 994 998
17. P.E. Nilsson, D. Bergqvist, G. Benoni, O. Bjorgell, H. Fredin, and U. Hedlund et al. The post-discharge prophylactic management of the orthopedic patient with low-molecular-weight heparin: enoxaparin Orthopedics 20 Suppl. Feb 1997 22 25