Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo

Journal of Steroid Biochemistry and Molecular Biology

Volumn 143, Issue , 2014, Pages 19-28

  Ming, Dong Sheng ^a   Pham, Steven ^a   Deb, Subrata ^a   Chin, Mei Yieng ^a   Kharmate, Geetanjali ^a   Adomat, Hans ^a   Beheshti, Elham Hosseini ^a   Locke, Jennifer ^a   Guns, Emma Tomlinson ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Androgen biosynthesis; Dihydrotestosterone; Pomegranate extracts; Prostate cancer; Testosterone; UPLC MS MS analysis

Indexed keywords

ACETIC ACID ETHYL ESTER; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANEDIONE; ANDROSTANOLONE; ANDROSTENEDIONE; ANDROSTERONE; HYDROXYPROGESTERONE; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POMEGRANATE EXTRACT; PRASTERONE; PREGNANEDIONE; PREGNENOLONE; PROGESTERONE; PROSTATE SPECIFIC ANTIGEN; STEROID; TESTOSTERONE; AR PROTEIN, HUMAN; PLANT EXTRACT; PTEN PROTEIN, MOUSE;

ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL LYSATE; CELL STRAIN LNCAP; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROSTATE CANCER; SOLID PHASE EXTRACTION; STEROID BLOOD LEVEL; STEROIDOGENESIS; TANDEM MASS SPECTROMETRY; TREATMENT DURATION; TREATMENT RESPONSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; LYTHRACEAE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATIC NEOPLASMS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; TUMOR CELL CULTURE;

ANDROGENS; ANDROSTENEDIONE; ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; DIHYDROTESTOSTERONE; HUMANS; IN VITRO TECHNIQUES; MALE; MICE; MICE, KNOCKOUT; PLANT EXTRACTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PTEN PHOSPHOHYDROLASE; PUNICACEAE; RECEPTORS, ANDROGEN; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 84896108090     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.02.006     Document Type: Article

References (32)

1. L. Wang, J. Ho, M. Glackin, and C. Matins-Green Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis Translational Oncology 5 2012 344 355
2. F. Staridi, E.M. Karapanagiotou, and K.N. Syrigos Targeted therapeutic approaches for hormone-refractory prostate cancer Cancer Treatment Reviews 36 2010 122 130
3. D.S. Correy, and K.J. Pienta New concepts in studying the control of normal cancer growth of the prostate Progress in Clinical and Biological Research 239 1987 1 73
4. J.R. Cheng, Y. Wu, J.J. Mohler, and C. Ip The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction Cancer Biology & Therapy 9 2010 1033 1042
5. N. Sharifi Minireview: androgen metabolism in castration resistant prostate cancer Molecular Endocrinology 27 2013 708 714
6. K.L. Noonan, S. North, R.L. Bitting, A.J. Armstrong, S.L. Ellard, and K.N. Chi Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide Annals of Oncology 24 2013 1802 1807
7. J. Richards, A.C. Lim, C.W. Hay, A.E. Taylor, A. Wingate, K.N. Owakowska, C. Pezaro, S. Carreira, J. Goodall, W. Arlt, I. McEwan, J.S. De Bono, and G. Attard Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100 Cancer Research 72 2012 2176 2182
8. A. Faria, and C. Galhau The bioactivity of pomegranate: impact on health and disease Critical Reviews in Food Sciences and Nutrition 51 2011 626 634
9. J. He, and M.M. Giusti Anthocyanins: natural colorants with health-promoting properties Annual Review Food Science Technology 1 2010 163 187
10. S.A. Naqvi, M.S. Khan, and S.B. Vohora Antibacterial, antifungal, and antihelminthic investigations on Indian medicinal plants Fitotherapia 62 1991 221 228
11. V.M. Adhami, N. Khan, and H. Mukhtar Cancer chemoprevention by pomegranate: laboratory and clinical evidence Nutrition and Cancer 61 2009 811 815
12. A.J. Pantuck, J.T. Leppert, N. Zomorodian, W. Aronson, J. Hong, R.J. Barnard, and A. Belldegrun Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer Clinical Cancer Research 12 2006 4018 4026 (Pubitemid 44078089)
13. N. Kroeger, A.S. Belldegrun, and A.J. Pantuck Pomegranate extracts in the management of men's urologic health: scientific rationale and preclinical and clinical data Evidence-Based Complementary and Alternative Medicine 2013 2013 1 9
14. S. Liu, J. Sjovall, and W.J. Griffiths Analysis of oxosteroids by nano-electospray mass spectrometry of their oximes Rapid Communications in Mass Spectrometry 14 2000 390 400 (Pubitemid 30152986)
15. T.F. Kalhorn, S.T. Page, W.N. Howald, E.A. Mostaghel, and P.S. Nelson Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry Rapid Communications in Mass Spectrometry 21 2007 3200 3206 (Pubitemid 47441781)
16. M. Moussavi, L. Fazli, H. Tearle, Y. Guo, M. Cox, J. Bell, C. Ong, W. Jia, and P.S. Rennie Oncolysis of prostate cancers induced by vesicular stomatitis virus in PTEN knockout mice Cancer Research 70 2010 1367 1376
17. S. Wang, J. Gao, Q. Lei, N. Rozengurt, C. Pritchard, J. Jiao, G. Thomas, G. Li, P. Roy-Burman, P. Nelson, X. Lin, and H. Wu Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer Cancer Cell 4 2003 209 221 (Pubitemid 37163835)
18. J. Gasmi, and T. Sanderson Growth inhibitory, antiandrogenic, and pro-apoptonic effects of punicic acid in LNCaP Human Prostate Cancer cells Journal of Agricultural and Food Chemistry 58 2010 12149 12156
19. S.G. Kasimsetty, D. Bialonska, M.K. Reddy, C. Thornton, K.L. Willett, and D. Ferreira Effects of Pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22RV1 prostate cancer cells Journal of Agricultural and Food Chemistry 57 2009 10636 10644
20. E.A. Mostaghel Intracrine androgen metabolisms in prostate cancer proression: Mechanisms of castration resistance and therapeutic implications Best Practice & Research Clinical Endocrinology & Metabolism 22 2008 243 258 (Pubitemid 351611949)
21. R. Auchus The backdoor pathway to dihydrotestosterone Trends in Endocrinology and Metabolism 15 2004 432 438 (Pubitemid 39440726)
22. M. Stanbrough, G.J. Bubley, K. Ross, T.R. Golub, M.A. Rubin, T.M. Penning, P.G. Febbo, and S.P. Balk Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer Cancer Research 66 2006 2815 2825
23. T.M. Penning, M.E. Burczynski, J.M. Jez, C. Hung, H. Lin, H. Ma, M. Moore, N. Palackal, and k. Ratnam Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: function plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex homones Biochemical Journal 351 2000 67 77
24. E. Koh, T. Noda, J. Kanaya, and M. Namiki Differential expression of 17beta-hydroxysteroid dehydrogenase isozyme genes in prostate cancer and noncancer tissues The Prostate 53 2002 154 159
25. K. Chang, R. Li, M. Papari-zareei, L. Watumull, Y. Daniel, R.J. Auchus, and N. Sharifi Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer Proceedings of the National Academy of Sciences of the United States of America 108 2010 13728 13733
26. K. Senthil, V. Manoj, K. Vuday, M. Errolla, K. Lakshmi, S. Soma, and P. Lakshmi Industrially Produced enzymes and their applications - an overview International Journal of Pharmaceutical and Chemical Sciences 1 2012 1069 1072
27. M.C. Byrns, R. Mindnich, L. Duan, and T.M. Penning Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology 130 2012 7 15
28. C. Cai, S. Chen, P. Ng, G.J. Bubley, P.S. Nelson, E. Mostaghel, and S.P. Balk Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors Cancer Research 71 2011 6503 6513
29. B. Harrow, and A. Mazur Textbook of Biochemistry 1958 Saunders Philadelphia, PA 109
30. R. Matrinek Practical clinical enzymology Journal of the American Medicine Technology 31 1969 162
31. J. Pfeiffer Enzymes, the Physics and Chemistry of Life 1954 Simon and Schuster New York, NY 171 173
32. J. Kim, and G.A. Coetzee Prostate specific antigen gene regulation by androgen receptor Journal of Cellular Biochemistry 93 2004 233 241 (Pubitemid 44264201)