The U-shaped relationship of traditional cardiovascular risk factors and adverse outcomes in later life

Aging and Disease

Volumn 3, Issue 4, 2012, Pages 339-351

  Abdelhafiz, Ahmed H ^a   Loo, Boon Eng ^a   Hensey, Nicola ^a   Bailey, Claire ^a   Sinclair, Alan ^b  

^a ROTHERHAM GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BEDFORDSHIRE   (United Kingdom)

Author keywords

Cardiovascular risk; Frailty; Malnutrition

Indexed keywords

EID: 84896064749     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review

References (59)

1. Vischer UM, Safar ME, Safar H, Iaria P, Le Dudal K, Henry O, Herrmann FR, Ducimetière P, Blacher J (2009). Cardiometabolic determinants of mortality in a geriatric population: Is there a "reverse metabolic syndrome"? Diabetes & Metabolism, 35: 108-114.
2. Bowden RG, Bounty Pl, Shelmadine B, Beaujean AA, Wilson RL, Hebert S (2011). Reverse Epidemiology of Lipid-Death Associations in a Cohort of End-Stage Renal Disease Patients. Nephron Clin Pract, 119: c214-c219.
3. Raphael CE, Whinnett ZI, Davies JE, Fontana M, Ferenczi EA, Manisty CH, Mayet J, Francis DP (2009). Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure. Heart, 95: 56-62.
4. Lee CK, Marschner IC, Simes RJ, Voysey M, Egleston B, Hudes G. de Souza P (2012). Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus. Clin Cancer Res, 18: 3188-3196.
5. Vapattanawong P, Aekplakorn W, Rakchanyaban U, Prasartkul P, Porapakkham Y (2010). Obesity and mortality among older Thais: a four year follow up study. BMC Public Health, 10: 604.
6. Kovacica JC, Leea P, Babera U, Karajgikara R, Evrarda SM, Morenoa P, Mehrana R, Fustera V, Dangasa G, Sharmaa SK, Kinia AS (2012). Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions. Atherosclerosis, 221: 176-182.
7. Gulsvik AK, Thelle DS, Mowe M, Wyller TB (2009). Increased mortality in the slim elderly: a 42 years follow-up study in a general population. Eur J Epidemiol, 24: 683-690.
8. Kvamme JM, Holmen J. Wilsgaard T, Florholmen J. Midthjell K, Jacobsen BK (2012). Body mass index and mortality in elderly men and women: the Tromsø and HUNT studies. J Epidemiol Community Health, 66: 611-617.
9. Zunzunegui MV, Sanchez MT, Garcia A, Casado JMR, Otero A (2012). Body Mass Index and Long-Term Mortality in an Elderly Mediterranean Population. J Aging Health, 24: 29-47.
10. Auyeung TW, Lee JSW, Leung J, Kwok T, Leung PC, Woo J (2010). Survival in Older Men May Benefi t From Being Slightly Overweight and Centrally Obese-A 5-Year Follow-up Study in 4,000 Older Adults Using DXA. J Gerontol A Biol Sci Med Sci, 65A: 99-104.
11. Bigaard J, Frederiksen K, Tjønneland A (2004). Body fat and fat-free mass and all cause mortality. Obes Res, 12: 2-9.
12. Bouillanne O, Dupont-Belmont C, Hay P, Hamon-Vilcot B, Cynober L, Aussel C (2009). Fat mass protects hospitalized elderly persons against morbidity and mortality. Am J Clin Nutr, 90: 505-510.
13. Schatz IJ, Masaki K, Yano K, Chen R, Rodriguez BL, Curb JD (2001). Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study. Lancet, 358: 351-355.
14. Newson RS, Felix JF, Heeringa J, Hofman A, Witteman JCM, Tiemeier H (2011). Association between serum cholesterol and noncardiovascular mortality in older age. J Am Geriatr Soc, 59: 1779-1785.
15. Landi F, Russo A, Pahor M, Capoluongo E, Liperoti R, Cesari M, Bernabei R, Onder G (2008). Serum high-density lipoprotein cholesterol levels and mortality in frail, community-living elderly. Gerontology, 54: 71-78.
16. Tuikkala P, Hartikainen S, Korhonen MJ, Lavikainen P, Kettunen R, Sulkava R, Enlund H (2010). Serum total cholesterol levels and all-cause mortality in a home-dwelling elderly population: a six-year follow-up. Scand J Prim Health Care, 28: 121-127.
17. Petersen LK, Christensen K, Kragstrup J (2010). Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds. Age Ageing, 39: 674-680.
18. Mielke MM, Zandi PP, Sjögren M, Gustafson D, Östling S, Steen B, Skoog I (2005). High total cholesterol levels in late life associated with a reduced risk of dementia. Neurology, 64: 1689-1695.
19. Solomon A, Kareholt I, Ngandu BM, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M (2007). Serum cholesterol changes after midlife and late-life cognition. Twenty-one-year follow-up study. Neurology, 68: 751-756.
20. Molander L, Lovheim H, Norman T, Nordstrom P, Gustafson Y (2008). Lower Systolic Blood Pressure Is Associated with greater mortality in people aged 85 and older. J Am Geriatr Soc, 56: 1853-1859.
21. Bangalore S, Qin J, Sloan S (2010). What is the optimal blood pressure in patients after acute coronary syndromes? Relationship of blood pressure and cardiovascular events in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction (PROVE IT-TIMI) 22 trial. Circulation, 122: 2142-2151.
22. Protogerou AD, Safar ME, Iaria P, Safar H, Le Dudal K, Filipovsky J, Henry O, Ducimetiere P, Blacher J (2007). Diastolic blood pressure and mortality in the elderly with cardiovascular disease. Hypertension, 50: 172-180.
23. Ungar A, Pepe G, Lambertucci L, Fedeli A, Monami M, Mannucci E, Gabbani L, Masotti G, Marchionni N, Di Bari M (2009). Low diastolic ambulatory blood pressure is associated with greater all-cause mortality in older patients with hypertension. J Am Geriatr Soc, 57: 291-296.
24. Werle1 MH, Moriguchi E, Fuchs SC, Bruscato NM, de Carli W, Fuchs FD (2011). Risk factors for cardiovascular disease in the very elderly: results of a cohort study in a city in southern Brazil. Eur J Cardiovasc Prev Rehabil, 18: 369-377.
25. Van Hateren KJJ, Landman GWD, Kleefstra N, Groenier KH, Kamper AM, Houweling ST, Bilo HJG (2010). Lower blood pressure associated with higher mortality in elderly diabetic patients (ZODIAC-12). Age Ageing, 39: 603-609.
26. Redon J, Mancia G, Sleight P, Schumacher H, Gao P (2012). Safety and efficacy of low blood pressures among patients with diabetes. Subgroup analyses from the ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial). J am Coll cardiol, 59: 74-83.
27. Pignone M (2010). Very intensive blood pressure control does not clearly reduce combined incidence of cardiovascular events. Clinical Diabetes, 28: 163-165.
28. Banach M, Bhatia V, Feller MA, Mujib M, Desai RV (2011). Relation of baseline systolic blood pressure and long-term outcomes in ambulatory patients with chronic mild to moderate heart failure. Am J Cardiol, 107: 1208-1214.
29. Guichard JL, Desai RV, Ahmed MI, Mujib M, Feller MA (2011). Isolated diastolic hypotension and incident heart failure in older adults. Hypertension, 58: 895-901.
30. Kovesdy CP, Trivedi BK, Kalantar-Zadeh K, Anderson JE (2006). Association of low blood pressure with increased mortality in patients with moderate to severe chronic kidney disease. Nephrol Dial Transplant, 21: 1257-1262.
31. Currie CJ, Peters JR, Tynan A, Evans M, Heine RJ, Bracco OL, Zagar T, Poole CD (2010). Survival as a function of HbA (1c) in people with type 2 diabetes: a retrospective cohort study. Lancet, 375: 481-489.
32. Huang ES, Liu JY, Moffet HH, John PM, Karter AJ (2011). Glycemic control, complications, and death in older diabetic patients. Diabetes Care, 34: 1329-1336.
33. Aguilar D, Bozkurt B, Ramasubbu K, Deswal A (2009). Relationship of hemoglobin A1C and mortality in heart failure patients with diabetes. J Am Coll Cardiol, 54: 422-428.
34. Eshaghian S, Horwich TB, Fonarow GC (2006). An unexpected inverse relationship between HbA1c levels and mortality in patients with diabetes and advanced systolic heart failure. Am Heart J, 151: 91.e1-91.e6.
35. Ukena C, Dobre D, Mahfoud F, Kindermann I, Lamiral Z, TALA S, Rossignol P, Turgonyi E, Pitt B, Bohm M, Zannad F (2012). Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: Data from EPHESUS. J Cardiac Fail, 18: 439-445.
36. Yang SW, Zhou YJ, Nie XM, Liu YY, Du J, Hu DY, Jia DA, Gao F, Hu B, Fang Z, Han HY, Liu XL, Yan ZX, Wang JL, Hua Q, Shi YJ, Li HW (2011). The BEAMIS Study Group. Effect of abnormal fasting plasma glucose level on all-cause mortality in older patients with acute myocardial infarction: results from the Beijing elderly acute myocardial infarction study (BEAMIS). Mayo Clin Proc, 86: 94-104.
37. Dungan KM, Binkley P, Nagaraja HN, Schuster D, Osei K (2011). The impact of glycemic control and glycemic variability on mortality in patients hospitalized with congestive heart failure. Diabetes Metab Res Rev, 27: 85-93.
38. Tomova GS, Nimbal V, Horwich TB (2012). Relation between hemoglobin A1c and outcomes in heart failure patients with and without diabetes mellitus. Am J Cardiol, 109: 1767-1773.
39. Manjunath G, Tighiouart H, Coresh J, Macleod B, Salem DN, Griffith JL, Levey AS, Sarnak MJ (2003). Level of kidney function as a risk factor for cardiovascular outcomes in the elderly. Kid Intern, 63: 1121-1129.
40. Cox HJ, Bhandari S, Rigby AS, Kilpatrick ES (2008). Mortality at Low and High Estimated Glomerular Filtration Rate Values: A 'U' Shaped Curve. Nephron Clin Pract, 110: c67-c72.
41. Shastri S, Katz R, Rifkin DE, Fried LF, Odden MC, Peralta CA, Chonchol M, Siscovick D, Shlipak MG, Newman AB, Sarnak MJ (2012). Kidney function and mortality in octogenarians: cardiovascular health study all stars. J Am Geriatr Soc, 60: 1201-1207.
42. Seliger SL, Longstreth Jr WT, Katz R, Manolio T, Fried LF, Shlipak M, Stehman-Breen CO, Newman A, Sarnak M, Gillen DL, Bleyer A, Siscovick DS (2005). Cystatin C and subclinical brain infarction. J Am Soc Nephrol, 16: 3721-3727.
43. de Ruijter W, Westendorp RGJ, Assendelft WJJ, den Elzen WPJ, de Craen AJM, le Cessie S, Gussekloo J (2008). Use of Framinghamrisk score andnewbiomarkers to predict cardiovascular mortality in older people: population based observational cohort study. BMJ, 337: a3083 doi:10.1136/bmj.a3083.
44. Mozaffarian D, Kamineni A, Prineas RJ, Siscovick DS (2008). Metabolic syndrome and mortality in older adults. the cardiovascular health study. Arch Intern Med, 168: 969-978.
45. Frystyk J, Berne C, Berglund L, Jensevik K, Flyvbjerg A and Zethelius B (2007). Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men. J Clin Endocrinol Metab, 92: 571-576.
46. Koenig W, Khuseyinova N, Baumert J, Meisinger C and Lowel H (2006). Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany. J Am Coll Cardiol, 48: 1369-1377.
47. Wannamethee1 SG, Welsh P, Whincup PH, Sawar N, Thomas MC, Gudnarsson V, Sattar N (2011). High adiponectin and increased risk of cardiovascular disease and mortality in asymptomatic older men: does NT-proBNP help to explain this association? Eur J Cardiovasc Prev Rehabil, 18: 65-71.
48. Poehls J, Wassel CL, Harris TB, Havel PJ, Swarbrick MM, Cummings SR, Newman AB, Satterfield S, Kanaya AM (2009). Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia, 52: 591-595
49. Singer JR, Palmas W, Teresi J, Weinstock R, Shea S, Luchsinger JA (2012). Adiponectin and all-cause mortality in elderly people with type 2 diabetes. Diabetes Care, 35: 1858-1863.
50. Shlipak MG, Katz R, Cushman M, Sarnak MJ, Stehman-Breen C, Psaty BM, Siscovick D, Tracy RP, Newman A, Fried L (2005). Cystatin-C and inflammatory markers in the ambulatory elderly. Am J Med, 118: 1416.e25-1416.e31.
51. Clarke R, Emberson JR, Breeze E, Casas JP, Parish S, Hingorani Ad, Fletcher A, Collins R, Smeeth L (2008). Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. Eur Heart J, 29: 800-809.
52. Strandberg TE, Strandberg AY, Salomaa VV, Pitkala KH, Tilvis PS, Sirola J, and Miettinen TA (2009). Explaining the obesity paradox: cardiovascular risk, weight change, and mortality during long-term follow-up in men. Eur Heart J, 30: 1720-1727.
53. Toss F, Wiklund P, Nordstrom P, Nordstrom A (2012). Body composition and mortality risk in later life. Age Ageing, 41: 677-681.
54. Tilvis RS, Valvanne JN, Strandberg TE, Miettinen TA (2011). Prognostic significance of serum cholesterol, lathosterol, and sitosterol in old age; a 17-year population study. Ann Med, 43: 292-301.
55. Dekker JM, Funahashi T, Nijpels G, Pilz S, Stehouwer CDA, Snijder MB, Bouter LM, Matsuzawa Y, Shimomura I, Heine RJ (2008). Prognostic value of adiponectin for cardiovascular disease and mortality. J Clin Endocrinol Metab, 93: 1489-1496.
56. Selvin E, SteffesMW, Zhu H (2010). Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med, 362: 800-811.
57. Carson AP, Fox CS, McGuire DK, Levitan EB, Laclaustra M, Mann DM, Muntner P (2010). Low hemoglobin A1c and risk of all-cause mortality among US adults without diabetes. Circ Cardiovasc Qual Outcomes, 3: 661-667.
58. Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Opler MG, Pickering TG, Rundle AG, Zammit GK, Malaspina D (2008). Sleep duration associated with mortality in elderly, but not middle-aged, adults in a large US sample. Sleep, 8: 1087-1096.
59. Tsou MT (2011). Association between sleep duration and health outcome in elderly Taiwanese. Intern J Gerontol, 5: 200-205.