Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets

European Journal of Immunology

Volumn 44, Issue 3, 2014, Pages 905-914

  Armour, Kathryn L ^a   Smith, Cheryl S ^a   Turner, Craig P ^b   Kirton, Christopher M ^a   Wilkes, Anthony M ^b   Hadley, Andrew G ^b   Ghevaert, Cedric ^a,b   Williamson, Lorna M ^b   Clark, Michael R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Blocking antibody; Fc engineering; IgG effector function; Low affinity Fc receptors

Indexed keywords

CD16 ANTIGEN; FC RECEPTOR IIB; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G4; PADGEM PROTEIN; RHESUS D ANTIBODY; THROMBOCYTE ANTIGEN;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CELL ADHESION; ERYTHROCYTE; MACROPHAGE; MOLECULAR INTERACTION; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; RADIOACTIVITY; THROMBOCYTE; THROMBOCYTE LIFESPAN;

BLOCKING ANTIBODY; FC ENGINEERING; IGG EFFECTOR FUNCTION; LOW-AFFINITY FC RECEPTORS;

ANTIGENS, HUMAN PLATELET; BLOOD PLATELETS; CELL SURVIVAL; ERYTHROCYTES; HUMANS; IMMUNOGLOBULIN G; MONOCYTES; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, IGG; RH-HR BLOOD-GROUP SYSTEM; TRANSCRIPTION FACTORS;

EID: 84896048567     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343825     Document Type: Article

References (19)

1. Armour, K. L., Clark, M. R., Hadley, A. G. and Williamson, L. M., Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities. Eur. J. Immunol. 1999. 29: 2613-2624.
2. Bye, J. M., Carter, C., Cui, Y., Gorick, B. D., Songsivilai, S., Winter, G., Hughes-Jones, N. C. et al., Germline variable region gene segment derivation of human monoclonal anti-RhD antibodies. J. Clin. Invest. 1992. 90: 2481-2490.
3. Armour, K. L., Williamson, L. M., Kumpel, B. M., Bux, J. and Clark, M. R., Mutant IgG lacking FcγRIII binding and ADCC activities [abstract]. Hematol. J. 2000. 1(Suppl.1): 27.
4. Armour, K. L., van de Winkel, J. G. J., Williamson, L. M. and Clark, M. R., Differential binding to human FcγRIIa and FcγRIIb receptors by human IgG wildtype and mutant antibodies. Mol. Immunol. 2003. 40: 585-593.
5. Armour, K. L., Parry-Jones, D. R., Beharry, N., Ballinger, J. R., Mushens, R., Williams, R. K., Beatty, C. et al., Intravascular survival of red cells coated with a mutated human anti-D antibody engineered to lack destructive activity. Blood. 2006. 107: 2619-2626.
6. Williamson, L. M., Hackett, G., Rennie, J., Palmer, C. R., Maciver, C., Hadfield, R., Hughes, D. et al., The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood. 1998. 92: 2280-2287.
7. Griffin, H. M. and Ouwehand, W. H., A human monoclonal antibody specific for the leucine-33 (P1A1, HPA-1a) form of platelet glycoprotein IIIa from a V gene phage display library. Blood. 1995. 86: 4430-4436.
8. Garner, S. F., Smethurst, P. A., Merieux, Y., Aeby, C., Smith, G., Armour, K. L., Scott, M. L. et al., A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a. Br. J. Haematol. 2000. 108: 440-447.
9. Ghevaert, C., Wilcox, D. A., Fang, J., Armour, K. L., Clark, M. R., Ouwehand, W. H. and Williamson, L. M., Developing recombinant HPA-1a-specific antibodies with abrogated Fcγ receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. J. Clin. Invest. 2008. 118: 2929-2938.
10. Ghevaert, C., Herbert, N., Hawkins, L., Grehan, N., Cookson, P., Garner, S., Lloyd-Evans, P. et al., A recombinant HPA-1a antibody with abrogated Fcγ receptor binding for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human studies. Blood. 2013. 122: 313-320.
11. Turner, C. P. and Hadley, A. G., The role of P-selectin in the immune destruction of platelets. Br. J. Haematol. 2003. 121: 623-631.
12. van Sorge, N. M., van der Pol, W. L. and van de Winkel, J. G., FcγR polymorphisms: implications for function, disease susceptibility and immunotherapy. Tissue Antigens. 2003. 61: 189-202.
13. Sondermann, P., Huber, R., Oosthuizen, V. and Jacob, U., The 3.2-Å crystal structure of the human IgG1 Fc fragment-FcγRIII complex. Nature. 2000. 406: 267-273.
14. Bratosin, D., Mazurier, J., Tissier, J. P., Estaquier, J., Huart, J. J., Ameisen, J. C., Aminoff, D. et al., Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie. 1998. 80: 173-195.
15. Brubaker, D. B., Marcus, C. and Holmes, E., Intravascular and total body platelet equilibrium in healthy volunteers and in thrombocytopenic patients transfused with single donor platelets. Am. J. Hematol. 1998. 58: 165-176.
16. Kirton, C. M., Laukkanen, M. L., Nieminen, A., Merinen, M., Stolen, C. M., Armour, K., Smith, D. J. et al., Function-blocking antibodies to human vascular adhesion protein-1: a potential anti-inflammatory therapy. Eur. J. Immunol. 2005. 35: 3119-3130.
17. Bux, J., Kissel, K., Hofmann, C. and Santoso, S., The use of allele-specific recombinant FcγRIIIb antigens for the detection of granulocyte antibodies. Blood. 1999. 93: 357-362.
18. Armour, K. L., Smith, C. S. and Clark, M. R., Expression of human FcγRIIIa as a GPI-linked molecule on CHO cells to enable measurement of human IgG binding. J. Immunol. Methods. 2010. 354: 20-33
19. Cavanagh, G., Dunn, A. N., Chapman, C. E. and Metcalfe, P., HPA genotyping by PCR sequence-specific priming (PCR-SSP): a streamlined method for rapid routine investigations. Transfus. Med. 1997. 7: 41-45.