New metabolite profiles of Danshensu in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 955-956, Issue 1, 2014, Pages 20-25

  Gu, Jun fei ^a,b   Feng, Liang ^a,b   Zhang, Ming hua ^b   Qin, Dong ^b   Jiang, Jun ^a,b   Cheng, Xu dong ^a,b   Ding, Shu min ^a,b   Yang, Shi lin ^c   Jia, Xiao bin ^a,b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^c Jiangxi Herbal Heavenly Science and Technology Co Ltd (NPEC)   (China)

Author keywords

Danshensu; Metabolic pathways; Metabolites; U HPLC Q TOF MS

Indexed keywords

ALKYLATION; BODY FLUIDS; INDUCTIVELY COUPLED PLASMA; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHYLATION; ORGANIC SOLVENTS; RATS;

BIOLOGICAL SAMPLES; DANSHENSU; LINEAR GRADIENT ELUTION; METABOLIC PATHWAYS; METABOLITE PROFILES; PROTEIN PRECIPITATION; U-HPLC/Q-TOF-MS; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY;

BIOMOLECULES;

3 (3 HYDROXYPHENYL 4 O SULPHATE) 2 HYDROXYPROPANOIC ACID; 3 (3 O GLUCURONYL 4 HYDROXYPHENYL) 2 PROPENOIC ACID; 3 (3 O METHYL 4 HYDROXYPHENYL) 2 HYDROXYPROPANOIC ACID; 3 (3 O SULPHATE 4 O METHYL) 2 PROPENOIC ACID; 3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; ACETONITRILE; DRUG METABOLITE; FORMIC ACID; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEHYDROGENATION; DEOXYGENATION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG STRUCTURE; DRUG URINE LEVEL; ELUTION; GLUCURONIDATION; IN VIVO STUDY; MALE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SENSITIVITY ANALYSIS; SULFATION; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS;

DANSHENSU; METABOLIC PATHWAYS; METABOLITES; U-HPLC/Q-TOF-MS;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; LACTATES; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84896048033     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.02.010     Document Type: Article

References (15)

1. Zhou L., Zuo Z., Chow M.S. J. Clin. Pharmacol. 2005, 45:1345.
2. Jiang M., Zhou M., Han Y.Q., Xing L., Zhao H.Z., Dong L.Y., Bai G., Luo G.A. J. Ethnopharmacol. 2013, 147:426.
3. Guan Y., Yin Y., Zhu Y.R., Guo C., Wei G., Duan J.L., Wang Y.H., Zhou D., Quan W., Weng Y., Xi M.M., Wen A.D. Evidence-Based Complementary Altern. Med. 2013, 10.1155/2013/972370.
4. Yin D., Yin J., Yang Y., Chen S., Gao X. J. Ethnopharmacol. 2013, 667.
5. Guan S., Ma J., Zhang Y., Gao Y., Zhang Y., Zhang X., Wang N., Xie Y., Wang J., Zhang J., Chu L. PLoS One 2013, e74318.
6. Du L.B., Miao X.X., Jiang Y.G., Jia H.Y., Tian Q., Shen J.G., Liu Y. Nanotoxicology 2013, 3:294.
7. Tian X.M., Wang R., Zhang B.K., Wang C.L., Guo H., Zhang S.J. Int. J. Ophthalmol. 2013, 6:59.
8. Wang F., Liu Y.Y., Liu L.Y., Zeng Q.J., Wang C.S., Sun K., Yang J.Y., Guo J., Fan J.Y., Han J.Y. Clin. Hemorheol. Microcirc. 2009, 42:7.
9. Han J.Y., Horie Y., Fan J.Y., Sun K., Guo J., Miura S., Hibi T. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G3.
10. Yang G.D., Zhang H., Lin R., Wang W.R., Shi X.L., Liu Y., Ji Q.L. Basic Clin. Pharmacol. Toxicol. 2009, 104:87.
11. Yin Y., Guan Y., Duan J.L., Wei G., Zhu Y.R., Quan W., Guo C., Zhou D., Wang Y.H., Xi M.M., Wen A.D. Eur. J. Pharmacol. 2013, 699:219.
12. Wang J., Ma Z., Hong Z., Song J. Zhongguo Zhong Yao Za Zhi 2011, 11:1516.
13. Zhang Z.C., Xu M., Sun S.F., Qiao X., Wang B.R., Han J., Guo D.A. J. Chromatogr. B 2008, 871:7.
14. Cui L., Sun E., Zhang Z.H., Qian Q., Tan X.B., Xu F.J., Jia X.B. J. Agric. Food Chem. 2013, 3589.
15. Zhao F.Q., Zheng N.X., Sato H., Adachi I., Horikoshi I. Biol. Pharm. Bull. 1997, 3:285.