-
1
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Saltz LB, Cox JV, Blanke C, Rosen LS, Fehrenbacher L, Moore MJ, Maroun JA, Ackland SP, Locker PK, Pirotta N (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343(13):905-914
-
(2000)
N Engl J Med
, vol.343
, Issue.13
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
Rosen, L.S.4
Fehrenbacher, L.5
Moore, M.J.6
Maroun, J.A.7
Ackland, S.P.8
Locker, P.K.9
Pirotta, N.10
-
2
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
DOI 10.1200/JCO.2004.05.113
-
Tournigand C, André T, Achille E, Lledo G, Flesh M, Mery-Mignard D, Quinaux E, Couteau C, Buyse M, Ganem G (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22(2):229-237 (Pubitemid 41095086)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.2
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
Lledo, G.4
Flesh, M.5
Mery-Mignard, D.6
Quinaux, E.7
Couteau, C.8
Buyse, M.9
Ganem, G.10
Landi, B.11
Colin, P.12
Louvet, C.13
De Gramont, A.14
-
3
-
-
24644457747
-
Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: A Multicenter Study of the Gruppo Oncologico Dell'Italia Meridionale
-
DOI 10.1200/JCO.2005.07.113
-
Colucci G, Gebbia V, Paoletti G, Giuliani F, Caruso M, Gebbia N, Cartenì G, Agostara B, Pezzella G, Manzione L (2005) Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 23(22):4866-4875 (Pubitemid 46223991)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.22
, pp. 4866-4875
-
-
Colucci, G.1
Gebbia, V.2
Paoletti, G.3
Giuliani, F.4
Caruso, M.5
Gebbia, N.6
Carteni, G.7
Agostara, B.8
Pezzella, G.9
Manzione, L.10
Borsellino, N.11
Misino, A.12
Romito, S.13
Durini, E.14
Cordio, S.15
Di, S.M.16
Lopez, M.17
Maiello, E.18
-
4
-
-
33644834827
-
Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: Individual patient data from 20,898 patients on 18 randomized trials
-
DOI 10.1200/JCO.2005.01.6071
-
Sargent DJ, Wieand HS, Haller DG, Gray R, Benedetti JK, Buyse M, Labianca R, Seitz JF, O'Callaghan CJ, Francini G (2005) Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 23(34):8664-8670 (Pubitemid 46211509)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.34
, pp. 8664-8670
-
-
Sargent, D.J.1
Wieand, H.S.2
Haller, D.G.3
Gray, R.4
Benedetti, J.K.5
Buyse, M.6
Labianca, R.7
Seitz, J.F.8
O'Callaghan, C.J.9
Francini, G.10
Grothey, A.11
O'Connell, M.12
Catalano, P.J.13
Blanke, C.D.14
Kerr, D.15
Green, E.16
Wolmark, N.17
Andre, T.18
Goldberg, R.M.19
De Gramont, A.20
more..
-
5
-
-
78149239651
-
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
-
Peeters M, Price TJ, Cervantes A, Sobrero AF, Ducreux M, Hotko Y, André T, Chan E, Lordick F, Punt CJA (2010) Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol 28(31):4706-4713
-
(2010)
J Clin Oncol
, vol.28
, Issue.31
, pp. 4706-4713
-
-
Peeters, M.1
Price, T.J.2
Cervantes, A.3
Sobrero, A.F.4
Ducreux, M.5
Hotko, Y.6
André, T.7
Chan, E.8
Lordick, F.9
Punt, C.J.A.10
-
6
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, D'Haens G, Pinté r T, Lim R, Bodoky G (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360(14):1408-1417
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
D'Haens, G.7
Pinté R, T.8
Lim, R.9
Bodoky, G.10
-
7
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
-
DOI 10.1038/sj.bjc.6603685, PII 6603685
-
Di Fiore F, Blanchard F, Charbonnier F, Le Pessot F, Lamy A, Galais M, Bastit L, Killian A, Sesboüé R, Tuech J (2007) Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 96(8):1166-1169 (Pubitemid 46625066)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.8
, pp. 1166-1169
-
-
Di, F.F.1
Blanchard, F.2
Charbonnier, F.3
Le, P.F.4
Lamy, A.5
Galais, M.P.6
Bastit, L.7
Killian, A.8
Sesboue, R.9
Tuech, J.J.10
Queuniet, A.M.11
Paillot, B.12
Sabourin, J.C.13
Michot, F.14
Michel, P.15
Frebourg, T.16
-
8
-
-
42649145667
-
Wildtype KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R (2008) Wildtype KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26(10):1626-1634
-
(2008)
J Clin Oncol
, vol.26
, Issue.10
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
Juan, T.7
Sikorski, R.8
Suggs, S.9
Radinsky, R.10
-
9
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A (2008) Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26(35):5705-5712
-
(2008)
J Clin Oncol
, vol.26
, Issue.35
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
De Dosso, S.7
Mazzucchelli, L.8
Frattini, M.9
Siena, S.10
Bardelli, A.11
-
10
-
-
68749119351
-
KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
-
Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, Masi G, Stasi I, Canestrari E, Rulli E, Floriani I, Bencardino K, Galluccio N, Catalano V, Tonini G, Magnani M, Fontanini G, Basolo F, Falcone A, Graziano F (2009) KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 101(4):715-721
-
(2009)
Br J Cancer
, vol.101
, Issue.4
, pp. 715-721
-
-
Loupakis, F.1
Ruzzo, A.2
Cremolini, C.3
Vincenzi, B.4
Salvatore, L.5
Santini, D.6
Masi, G.7
Stasi, I.8
Canestrari, E.9
Rulli, E.10
Floriani, I.11
Bencardino, K.12
Galluccio, N.13
Catalano, V.14
Tonini, G.15
Magnani, M.16
Fontanini, G.17
Basolo, F.18
Falcone, A.19
Graziano, F.20
more..
-
11
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, Schlichting M, Zubel A, Celik I, Rougier P, Ciardiello F (2011) Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 29(15):2011-2019
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
Folprecht, G.4
Nowacki, M.P.5
Cascinu, S.6
Shchepotin, I.7
Maurel, J.8
Cunningham, D.9
Tejpar, S.10
Schlichting, M.11
Zubel, A.12
Celik, I.13
Rougier, P.14
Ciardiello, F.15
-
12
-
-
79956310674
-
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
-
Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P (2011) Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 22(7):1535-1546
-
(2011)
Ann Oncol
, vol.22
, Issue.7
, pp. 1535-1546
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.T.3
De Braud, F.4
Schuch, G.5
Zubel, A.6
Celik, I.7
Schlichting, M.8
Koralewski, P.9
-
13
-
-
81755161614
-
Efficacy of first-line systemic treatment in correlation with BRAF V600E and different KRAS mutations in metastatic colorectal cancer-a single institution retrospective analysis
-
Rebersek M, Boc M, Cerkovnik P, Benedik J, Hlebanja Z, Volk N, Novakovic S, Ocvirk J (2011) Efficacy of first-line systemic treatment in correlation with BRAF V600E and different KRAS mutations in metastatic colorectal cancer-a single institution retrospective analysis. Radiol Oncol 45(4):285-291
-
(2011)
Radiol Oncol
, vol.45
, Issue.4
, pp. 285-291
-
-
Rebersek, M.1
Boc, M.2
Cerkovnik, P.3
Benedik, J.4
Hlebanja, Z.5
Volk, N.6
Novakovic, S.7
Ocvirk, J.8
-
14
-
-
75649119933
-
BRAF mutation is associated with a decreased outcome in patients (pts) with advanced colorectal cancer (ACC) treated with chemotherapy and bevacizumab with or without cetuximab
-
Tol J, Dijkstra JR, Vink-Borger ME, Koopman M, Vincent AD, Van Krieken JHJM, Ligtenberg MJL, Nagtegaal ID, Punt CJA (2009) BRAF mutation is associated with a decreased outcome in patients (pts) with advanced colorectal cancer (ACC) treated with chemotherapy and bevacizumab with or without cetuximab. Eur J Cancer Suppl 7(2-3):321
-
(2009)
Eur J Cancer Suppl
, vol.7
, Issue.2-3
, pp. 321
-
-
Tol, J.1
Dijkstra, J.R.2
Vink-Borger, M.E.3
Koopman, M.4
Vincent, A.D.5
Van Krieken, J.H.J.M.6
Ligtenberg, M.J.L.7
Nagtegaal, I.D.8
Punt, C.J.A.9
-
15
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJM, Schrama JG, Erdkamp FLG, Vos AH, van Groeningen CJ, Sinnige HAM (2009) Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 360(6):563-572
-
(2009)
N Engl J Med
, vol.360
, Issue.6
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.M.5
Schrama, J.G.6
Erdkamp, F.L.G.7
Vos, A.H.8
Van Groeningen, C.J.9
Sinnige, H.A.M.10
-
16
-
-
77954215850
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
-
Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Borger ME, van Cleef PH, van Krieken JH, Punt CJA, Nagtegaal ID (2010) Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 46(11):1997-2009
-
(2010)
Eur J Cancer
, vol.46
, Issue.11
, pp. 1997-2009
-
-
Tol, J.1
Dijkstra, J.R.2
Klomp, M.3
Teerenstra, S.4
Dommerholt, M.5
Vink-Borger, M.E.6
Van Cleef, P.H.7
Van Krieken, J.H.8
Punt, C.J.A.9
Nagtegaal, I.D.10
-
17
-
-
84896036142
-
Prognostic and predictive significance of BRAF mutation in patients with metastatic colorectal cancer treated with 5-fluorouracil-based 1st line chemotherapy
-
Saridaki Z, Tzardi M, Papadatos-Patsos D, Kampouraki E, Zois E, Stathopoulos E, Georgoulias V, Mavroudis D, Souglakos J (2009) Prognostic and predictive significance of BRAF mutation in patients with metastatic colorectal cancer treated with 5-fluorouracil-based 1st line chemotherapy. Eur J Cancer Suppl 7(2-3):91-92
-
(2009)
Eur J Cancer Suppl
, vol.7
, Issue.2-3
, pp. 91-92
-
-
Saridaki, Z.1
Tzardi, M.2
Papadatos-Patsos, D.3
Kampouraki, E.4
Zois, E.5
Stathopoulos, E.6
Georgoulias, V.7
Mavroudis, D.8
Souglakos, J.9
-
18
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
Bokemeyer C, Cutsem EV, Rougier P, Ciardiello F, Heeger S, Schlichting M, Celik I, Kohne CH (2012) Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer 48(10):1466-1475
-
(2012)
Eur J Cancer
, vol.48
, Issue.10
, pp. 1466-1475
-
-
Bokemeyer, C.1
Cutsem, E.V.2
Rougier, P.3
Ciardiello, F.4
Heeger, S.5
Schlichting, M.6
Celik, I.7
Kohne, C.H.8
-
19
-
-
79959337678
-
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
-
Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, Wilson RH, Idziaszczyk S, Harris R, Fisher D, Kenny SL, Kay E, Mitchell JK, Madi A, Jasani B, James MD, Bridgewater J, Kennedy MJ, Claes B, Lambrechts D, Kaplan R, Cheadle JP (2011) Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 377(9783):2103-2114
-
(2011)
Lancet
, vol.377
, Issue.9783
, pp. 2103-2114
-
-
Maughan, T.S.1
Adams, R.A.2
Smith, C.G.3
Meade, A.M.4
Seymour, M.T.5
Wilson, R.H.6
Idziaszczyk, S.7
Harris, R.8
Fisher, D.9
Kenny, S.L.10
Kay, E.11
Mitchell, J.K.12
Madi, A.13
Jasani, B.14
James, M.D.15
Bridgewater, J.16
Kennedy, M.J.17
Claes, B.18
Lambrechts, D.19
Kaplan, R.20
Cheadle, J.P.21
more..
-
20
-
-
84861432557
-
Phase III Trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: The NORDIC-VII study
-
Tveit KM, Guren T, Glimelius B, Pfeiffer P, Sorbye H, Pyrhonen S, Sigurdsson F, Kure E, Ikdahl T, Skovlund E, Fokstuen T, Hansen F, Hofsli E, Birkemeyer E, Johnsson A, Starkhammar H, Yilmaz MK, Keldsen N, Erdal AB, Dajani O, Dahl O, Christoffersen T (2012) Phase III Trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol 30(15):1755-1762
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
, pp. 1755-1762
-
-
Tveit, K.M.1
Guren, T.2
Glimelius, B.3
Pfeiffer, P.4
Sorbye, H.5
Pyrhonen, S.6
Sigurdsson, F.7
Kure, E.8
Ikdahl, T.9
Skovlund, E.10
Fokstuen, T.11
Hansen, F.12
Hofsli, E.13
Birkemeyer, E.14
Johnsson, A.15
Starkhammar, H.16
Yilmaz, M.K.17
Keldsen, N.18
Erdal, A.B.19
Dajani, O.20
Dahl, O.21
Christoffersen, T.22
more..
-
21
-
-
84861796999
-
The influence of KRAS and BRAF mutations on the efficacy of cetuximab-based first-line therapy of metastatic colorectal cancer: An analysis of the AIO KRK-0104-trial
-
doi:10.1002/ijc.26467
-
Modest DP, Jung A, Moosmann N, Laubender RP, Giessen C, Schulz C, Haas M, Neumann J, Boeck S, Kirchner T, Heinemann V, Stintzing S (2012) The influence of KRAS and BRAF mutations on the efficacy of cetuximab-based first-line therapy of metastatic colorectal cancer: an analysis of the AIO KRK-0104-trial. Int J Cancer 131(4):980-986. doi:10.1002/ijc.26467
-
(2012)
Int J Cancer
, vol.131
, Issue.4
, pp. 980-986
-
-
Modest, D.P.1
Jung, A.2
Moosmann, N.3
Laubender, R.P.4
Giessen, C.5
Schulz, C.6
Haas, M.7
Neumann, J.8
Boeck, S.9
Kirchner, T.10
Heinemann, V.11
Stintzing, S.12
-
22
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
-
DOI 10.1056/NEJMoa033025
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351(4):337-345 (Pubitemid 38944402)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
23
-
-
84857993465
-
Clinical impact of antiepidermal growth factor receptor monoclonal antibodies in firstline treatment of metastatic colorectal cancer
-
doi:10.1002/cncr.26460
-
Loupakis F, Cremolini C, Salvatore L, Schirripa M, Lonardi S, Vaccaro V, Cuppone F, Giannarelli D, Zagonel V, Cognetti F, Tortora G, Falcone A, Bria E (2012) Clinical impact of antiepidermal growth factor receptor monoclonal antibodies in firstline treatment of metastatic colorectal cancer. Cancer 118(6):1523-1532. doi:10.1002/cncr.26460
-
(2012)
Cancer
, vol.118
, Issue.6
, pp. 1523-1532
-
-
Loupakis, F.1
Cremolini, C.2
Salvatore, L.3
Schirripa, M.4
Lonardi, S.5
Vaccaro, V.6
Cuppone, F.7
Giannarelli, D.8
Zagonel, V.9
Cognetti, F.10
Tortora, G.11
Falcone, A.12
Bria, E.13
-
24
-
-
79960932729
-
BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: A metaanalysis
-
Mao C, Liao R-Y, Qiu L-X, Wang X-W, Ding H, Chen Q (2011) BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a metaanalysis. Mol Biol Rep 38(4):2219-2223
-
(2011)
Mol Biol Rep
, vol.38
, Issue.4
, pp. 2219-2223
-
-
Mao, C.1
Liao, R.-Y.2
Qiu, L.-X.3
Wang, X.-W.4
Ding, H.5
Chen, Q.6
|