Exposure to diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes

Molecular Biology Reports

Volumn 41, Issue 3, 2014, Pages 1227-1235

  Li, Lan ^a,b   Zhang, Teng ^a   Qin, Xun Si ^a   Ge, Wei ^a   Ma, Hua Gang ^c   Sun, Li Lan ^c   Hou, Zhu Mei ^a   Chen, Hong ^b   Chen, Ping ^d   Qin, Guo Qing ^e   Shen, Wei ^a   Zhang, Xi Feng ^d  

^a QINGDAO AGRICULTURAL UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

^c WEIFANG PEOPLE'S HOSPITAL   (China)

^d WUHAN POLYTECHNIC UNIVERSITY   (China)

^e InnoTech Nutrition Solutions   (Canada)

Author keywords

DEHP; DNA methylation; Imprint genes; Oocytes; Primordial germ cells

Indexed keywords

PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; FEMALE; FETUS; GENE; GENOME IMPRINTING; IGF2R GENE; MALE; METHYLATION; MOUSE; NONHUMAN; OOCYTE; PEG3 GENE; PRIMORDIAL GERM CELL; PROGENY;

ANIMALIA; MUS;

ANIMALS; DIETHYLHEXYL PHTHALATE; DNA METHYLATION; FEMALE; GENOMIC IMPRINTING; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; OOCYTES; OOGENESIS; PREGNANCY; RECEPTOR, IGF TYPE 2;

EID: 84896028970     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2967-7     Document Type: Article

References (27)

1. Singh S, Li SS (2012) Epigenetic effects of environmental chemicals bisphenol a and phthalates. Int J Mol Sci 13(8):10143-10153
2. Zhang T, Li L, Qin XS, Zhou Y, Zhang XF, Wang LQ, De Felici M, Chen H, Qin GQ, Shen W (2013b). Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro. Environ Mol Mutagen
3. Zhang XF, Zhang LJ, Li L, Feng YN, Chen B, Ma JM, Huynh E, Shi QH, De Felici M, Shen W (2013) Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse. Environ Mol Mutagen 54(5):354-361
4. Zhang XF, Zhang T, Wang L, Zhang HY, Chen YD, Qin XS, Feng YM, Feng YN, Shen W, Li L (2013) Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Mol Biol Rep 40:6509-6517
5. Ambruosi B, Uranio MF, Sardanelli AM, Pocar P, Martino NA, Paternoster MS, Amati F, Dell'Aquila ME (2009) In vitro acute exposure to DEHP affects oocyte meiotic maturation, energy and oxidative stress parameters in a large animal model. PLoS One 6(11):e27452
6. Braun JM, Smith KW, Williams PL, Calafat AM, Berry K, Ehrlich S, Hauser R (2012) Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy. Environ Health Perspect 120(5):739-745
7. Carnevali O, Tosti L, Speciale C, Peng C, Zhu Y, Maradonna F (2010) DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis. PLoS One 5(4):e10201
8. Dalman A, Eimani H, Sepehri H, Ashtiani SK, Valojerdi MR, Eftekhari-Yazdi P, Shahverdi A (2008) Effect of mono-(2-ethylhexyl) phthalate (MEHP) on resumption of meiosis, in vitro maturation and embryo development of immature mouse oocytes. BioFactors 33(2):149-155
9. Lovekamp TN, Davis BJ (2001) Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol 172(3):217-224 (Pubitemid 32406029)
10. Zhang GL, Zhang XF, Feng YM, Li L, Sun XF, Sun ZY, Shen W (2013) Exposure to bisphenol A results in a decline in mouse spermatogenesis. Reprod Fertil Dev 25(6):847-859
11. Song ZH, Min LJ, Pan QJ, Shi QH, Shen W (2009) Maternal imprinting during mouse oocyte growth in vivo and in vitro. Biochem Biophys Res Commun 387:800-805
12. Chao HH, Zhang XF, Chen B, Pan B, Zhang LJ, Li L, Sun XF, Shi QH, Shen W (2012) Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway. Histochem Cell Biol 137(2):249-259
13. Eichenlaub-Ritter U, Vogt E, Cukurcam S, Sun F, Pacchierotti F, Parry J (2008) Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy. Mutat Res 651(1-2):82-92
14. Hunt PA, Lawson C, Gieske M, Murdoch B, Smith H, Marre A, Hassold T, VandeVoort CA (2012) Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc Natl Acad Sci USA 109(43):17525-17530
15. Anderson OS, Nahar MS, Faulk C, Jones TR, Liao C, Kannan K, Weinhouse C, Rozek LS, Dolinoy DC (2012) Epigenetic responses following maternal dietary exposure to physiologically relevant levels of bisphenol A. Environ Mol Mutagen 53(5):334-342
16. Susiarjo M, Sasson I, Mesaros C, Bartolomei MS (2013) Bisphenol A exposure disrupts genomic imprinting in the mouse. PLoS Genet 9(4):e1003401
17. Zhang HQ, Zhang XF, Zhang LJ, Chao HH, Pan B, Feng YM, Li L, Sun XF, Shen W (2012) Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Mol Biol Rep 39(5):5651-5657
18. Zhang XF, Zhang LJ, Feng YN, Chen B, Feng YM, Liang GJ, Li L, Shen W (2012) Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells. Mol Biol Rep 39(9):8621-8628
19. Pesce M, De Felici M (1995) Purification of mouse primordial germ cells by MiniMACS magnetic separation system. Dev Biol 170:722-725
20. Bromer JG, Zhou Y, Taylor MB, Doherty L, Taylor HS (2010) Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. FASEB J 24(7):2273-2280
21. Kundakovic M, Gudsnuk K, Franks B, Madrid J, Miller RL, Perera FP, Champagne FA (2013) Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure. Proc Natl Acad Sci USA 110(24):9956-9961
22. Kundakovic M, Champagne FA (2011) Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav Immun 25:1084-1093
23. Dolinoy DC, Huang D, Jirtle RL (2007) Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci USA 104(32):13056-13061 (Pubitemid 351737592)
24. Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S (2008) Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun 376:563-567
25. Pathak S, D'Souza R, Ankolkar M, Gaonkar R, Balasinor NH (2010) Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Mol Cell Endocrinol 15:110-117
26. Pathak S, Kedia-Mokashi N, Saxena M, D'Souza R, Maitra A, Parte P, Gill-Sharma M, Balasinor N (2009) Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Fertil Steril 91:2253-2263
27. Doshi T, D'souza C, Vanage G (2013) Aberrant DNA methylation at Igf2-H19 imprinting control region in spermatozoa upon neonatal exposure to bisphenol A and its association with post implantation loss. Mol Biol Rep 40(8):4747-4757