Expression of HMGA2 in bladder cancer and its association with epithelial-to-mesenchymal transition

Cell Proliferation

Volumn 47, Issue 2, 2014, Pages 146-151

  Ding, X ^a   Wang, Y ^a   Ma, X ^a   Guo, H ^a   Yan, X ^a   Chi, Q ^a   Li, J ^a   Hou, Y ^a   Wang, C ^a  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; UVOMORULIN; VIMENTIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUES; TRANSITIONAL CELL CARCINOMA; UPREGULATION; VERY ELDERLY; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, TRANSITIONAL CELL; CELL LINE, TUMOR; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HMGA2 PROTEIN; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; RNA, MESSENGER; RNA, NEOPLASM; URINARY BLADDER NEOPLASMS; VIMENTIN;

EID: 84895923709     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12096     Document Type: Article

References (22)

1. Gao D, Vahdat LT, Wong S, Chang JC, Mittal V (2012) Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res. 72, 4883-4889.
2. Sánchez-Tilló E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M et al. (2012) EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell. Mol. Life Sci. 69, 3429-3456.
3. Bates RC, Mercurio AM (2005) The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol. Ther. 4, 365-370.
4. Cleynen I, Van de Ven WJ (2008) The HMGA proteins: a myriad of functions (Review). Int. J. Oncol. 32, 289-305.
5. Di Cello F, Hillion J, Hristov A, Wood LJ, Mukherjee M, Schuldenfrei A et al. (2008) HMGA2 participates in transformation in human lung cancer. Mol. Cancer Res. 6, 743-750.
6. Wend P, Runke S, Wend K, Anchondo B, Yesayan M, Jardon M et al. (2013) WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol. Med. 5, 264-279.
7. Jin L, Lloyd RV, Nassar A, Lappinga PJ, Sebo TJ, Swartz K et al. (2011) HMGA2 expression analysis in cytological and paraffin-embedded tissue specimens of thyroid tumors by relative quantitative RT-PCR. Diagn. Mol. Pathol. 20, 71-80.
8. Zha L, Zhang J, Tang W, Zhang N, He M, Guo Y et al. (2013) HMGA2 elicits EMT by activating the Wnt/β-catenin pathway in gastric cancer. Dig. Dis. Sci. 58, 724-733.
9. Hetland TE, Holth A, Kærn J, Flørenes VA, Tropé CG, Davidson B (2012) HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases. Virchows Arch. 460, 505-513.
10. Venkatesan N, Krishnakumar S, Deepa PR, Deepa M, Khetan V, Reddy MA (2012) Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells. Mol. Vis. 18, 2420-2437.
11. Morishita A, Zaidi MR, Mitoro A, Sankarasharma D, Szabolcs M, Okada Y et al. (2013) HMGA2 is a driver of tumor metastasis. Cancer Res. 73, 4289-4299.
12. Yang GL, Zhang LH, Bo JJ, Hou KL, Cai X, Chen YY et al. (2011) Overexpression of HMGA2 in bladder cancer and its association with clinicopathologic features and prognosis HMGA2 as a prognostic marker of bladder cancer. Eur. J. Surg. Oncol. 37, 265-271.
13. Tian W, Wang G, Yang J, Pan Y, Ma Y (2013) Prognostic role of E-cadherin and vimentin expression in various subtypes of soft tissue leiomyosarcomas. Med. Oncol. 30, 401.
14. Fedele M, Palmieri D, Fusco A (2010) HMGA2: a pituitary tumour subtype-specific oncogene? Mol. Cell. Endocrinol. 15, 19-24.
15. Katsuno Y, Lamouille S, Derynck R (2013) TGF-β signaling and epithelial-mesenchymal transition in cancer progression. Curr. Opin. Oncol. 25, 76-84.
16. Nurwidya F, Takahashi F, Murakami A, Takahashi K (2012) Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer. Cancer Res. Treat. 44, 151-156.
17. van der Horst G, Bos L, van der Pluijm G (2012) Epithelial plasticity, cancer stem cells, and the tumor-supportive stroma in bladder carcinoma. Mol. Cancer Res. 10, 995-1009.
18. Majid S, Dar AA, Saini S, Deng G, Chang I, Greene K et al. (2013) MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer. PLoS One 8, e67686.
19. Fujii T, Shimada K, Anai S, Fujimoto K, Konishi N (2013) ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression. Cancer Sci. 104, 321-327.
20. Ying L, Chen Q, Wang Y, Zhou Z, Huang Y, Qiu F (2012) Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol. BioSyst. 8, 2289-2294.
21. Hu H, Wang YL, Wang GW, Wong YC, Wang XF, Wang Y et al. (2013) A novel role of Id-1 in regulation of epithelial-to-mesenchymal transition in bladder cancer. Urol. Oncol. 31, 1242-1253.
22. Wu J, Liu Z, Shao C, Gong Y, Hernando E, Lee P et al. (2011) HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res. 15, 349-359.