Increasing incidence of pyogenic spondylodiscitis: A 14-year population-based study

Journal of Infection

Volumn 68, Issue 4, 2014, Pages 313-320

  Kehrer, Michala ^a,b   Pedersen, Court ^a,b   Jensen, Thøger G ^b   Lassen, Annmarie T ^a,b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Epidemiology; Incidence; Patient characteristics; Population based; Pyogenic spondylodiscitis; Vertebral osteomyelitis

Indexed keywords

ADULT; AGED; ALCOHOL ABUSE; ARTICLE; BACKACHE; BIOPSY; BONE SCINTISCANNING; CAUDA EQUINA SYNDROME; COAGULASE NEGATIVE STAPHYLOCOCCUS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENMARK; DIABETES MELLITUS; ENDOCARDITIS; ESCHERICHIA COLI; FEMALE; FEVER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INCIDENCE; INFECTIOUS COMPLICATION; INTERVERTEBRAL DISK DEGENERATION; INTRASPINAL ABSCESS; LEUCOCYTE SCINTIGRAPHY; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC DISEASE; PARAVERTEBRAL ABSCESS; POPULATION RESEARCH; PSOAS ABSCESS; PYOGENIC SPONDYLODISCITIS; SCIATICA; SCINTIGRAPHY; SPINAL CORD INJURY; STAPHYLOCOCCUS AUREUS; WEIGHT REDUCTION;

EPIDEMIOLOGY; INCIDENCE; PATIENT CHARACTERISTICS; POPULATION-BASED; PYOGENIC SPONDYLODISCITIS; VERTEBRAL OSTEOMYELITIS;

ADULT; AGE FACTORS; AGED; BACTERIAL INFECTIONS; DENMARK; DISCITIS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84895918942     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2013.11.011     Document Type: Article

References (34)

1. McHenry M.C., Easley K.A., Locker G.A. Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 2002, 34(10):1342-1350.
2. Solis Garcia del P.J., Vives S.M., Solera J. Vertebral osteomyelitis: long-term disability assessment and prognostic factors. J Infect 2007, 54(2):129-134.
3. Luzzati R., Giacomazzi D., Danzi M.C., Tacconi L., Concia E., Vento S. Diagnosis, management and outcome of clinically- suspected spinal infection. J Infect 2009, 58(4):259-265.
4. Zimmerli W. Clinical practice. Vertebral osteomyelitis. N Engl J Med 2010, 362(11):1022-1029.
5. Treatment duration of vertebral osteomyelitis, a clinical trial comparing 6 versus 12 weeks of antibiotic therapy. Interscience conference on antimicrobial agents and chemotherapy 2013, [Denver, CO]. A. Dinh, D. Mulleman, I. Ghout, B. Marchou, B. Issartel, V. Zeller (Eds.).
6. Beronius M., Bergman B., Andersson R. Vertebral osteomyelitis in Goteborg, Sweden: a retrospective study of patients during 1990-95. ScandJ InfectDis 2001, 33(7):527-532.
7. Grammatico L., Baron S., Rusch E., Lepage B., Surer N., Desenclos J.C., et al. Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002-2003. Epidemiol Infect 2008, 136(5):653-660.
8. Lora-Tamayo J., Euba G., Narvaez J.A., Murillo O., Verdaguer R., Sobrino B., et al. Changing trends in the epidemiology of pyogenic vertebral osteomyelitis: the impact of cases with no microbiologic diagnosis. SeminArthritis Rheum 2011, 41(2):247-255.
9. Jensen A.G., Espersen F., Skinhoj P., Rosdahl V.T., Frimodt-Moller N. Increasing frequency of vertebral osteomyelitis following Staphylococcus aureus bacteraemia in Denmark 1980-1990. J Infect 1997, 34(2):113-118.
10. Hutchinson C., Hanger C., Wilkinson T., Sainsbury R., Pithie A. Spontaneous spinal infections in older people. Intern Med J 2009, 39(12):845-848.
11. Gouliouris T., Aliyu S.H., Brown N.M. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 2010, 65(Suppl. 3):11-24. 10.1093/jac/dkq303.
12. Zimmerli W. Clinical practice. Vertebral osteomyelitis. N Engl J Med 2010, 362(11):1022-1029. 10.1056/NEJMcp0910753.
13. Modic M.T., Feiglin D.H., Piraino D.W., Boumphrey F., Weinstein M.A., Duchesneau P.M., et al. Vertebral osteomyelitis: assessment using MR. Radiology 1985, 157(1):157-166. 10.1148/radiology.157.1.3875878.
14. Bateman J.L., Pevzner M.M. Spinal osteomyelitis: a review of 10 years' experience. Orthopedics 1995, 18(6):561-565.
15. Nolla J.M., Ariza J., Gomez-Vaquero C., Fiter J., Bermejo J., Valverde J., et al. Spontaneous pyogenic vertebral osteomyelitis in nondrug users. Semin Arthritis Rheum 2002, 31(4):271-278.
16. Colmenero J.D., Jimenez-Mejias M.E., Sanchez-Lora F.J., Reguera J.M., Palomino-Nicas J., Martos F., et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis 1997, 56(12):709-715.
17. Bhavan K.P., Marschall J., Olsen M.A., Fraser V.J., Wright N.M., Warren D.K. The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital. BMCInfectDis 2010, 10:158,.
18. Statistics Denmark September 24, 2012, Available from:, and, and. http://www.statistikbanken.dk/BEF607.
19. Pedersen C.B. The Danish Civil Registration system. Scand J Public Health 2011, 39(7 Suppl.):22-25. 10.1177/1403494810387965.
20. Lynge E., Sandegaard J.L., Rebolj M. The Danish National patient register. Scand J Public Health 2011, 39(7 Suppl.):30-33. 10.1177/1403494811401482.
21. Micallef L. eulerAPE 2.0.3 school of computing 2012, University of KentCanterbury, Canterbury, UK, [updated 14 November 2012; cited 2013 28 october]. Available from:. http://www.eulerdiagrams.org/eulerAPE/.
22. Cameron A., Trivedi P.K. Microeconometrics sing stata 2009, 692. Stata Press.
23. Krogsgaard M.R., Wagn P., Bengtsson J. Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 1978-1982, compared to cases reported to the National Patient Register 1991-1993. Acta Orthop Scand 1998, 69(5):513-517.
24. Akiyama T., Chikuda H., Yasunaga H., Horiguchi H., Fushimi K., Saita K. Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database. BMJ Open 2013, 3(3). 10.1136/bmjopen-2012-002412.
25. Mejer N., Westh H., Schonheyder H.C., Jensen A.G., Larsen A.R., Skov R., et al. Stable incidence and continued improvement in short term mortality of Staphylococcus aureus bacteraemia between 1995 and 2008. BMC Infect Dis 2012, 12:260. 10.1186/1471-2334-12-260.
26. Sobottke R., Rollinghoff M., Zarghooni K., Schluter-Brust K., Delank K.S., Seifert H., et al. Spondylodiscitis in the elderly patient: clinical mid-term results and quality of life. Arch Orthop Trauma Surg 2010, 130(9):1083-1091.
27. Cebrian Parra J.L., Saez-Arenillas Martin A., Urda Martinez-Aedo A.L., Soler Ivanez I., Agreda E., Lopez-Duran Stern L. Management of infectious discitis. Outcome in one hundred and eight patients in a university hospital. Int Orthop 2012, 36(2):239-244. 10.1007/s00264-011-1445-x.
28. D'Agostino C., Scorzolini L., Massetti A.P., Carnevalini M., d'Ettorre G., Venditti M., et al. A seven-year prospective study on spondylodiscitis: epidemiological and microbiological features. Infection 2010, 38(2):102-107.
29. Pigrau C., Almirante B., Flores X., Falco V., Rodriguez D., Gasser I., et al. Spontaneous pyogenic vertebral osteomyelitis and endocarditis: incidence, risk factors, and outcome. AmJ Med 2005, 118(11):1287,.
30. Aagaard T., Roed C., Dragsted C., Skinhoj P. Microbiological andtherapeutic challenges in infectious spondylodiscitis: a cohort study of 100 cases, 2006-2011. Scand J Infect Dis 2013, 45(6):417-424. 10.3109/00365548.2012.753160.
31. Citak M., Backhaus M., Kalicke T., Hilal Z., Muhr G., Frangen T.M. Myths and facts of spondylodiscitis: an analysis of 183 cases. Acta Orthop Belg 2011, 77(4):535-538.
32. Karadimas E.J., Bunger C., Lindblad B.E., Hansen E.S., Hoy K., Helmig P., et al. Spondylodiscitis. A retrospective study of 163 patients. Acta Orthop 2008, 79(5):650-659.
33. Frank L. Epidemiology. When an entire country is a cohort. Science 2000, 287(5462):2398-2399.
34. Pedersen E.G., Hallas J., Hansen K., Jensen P.E., Gaist D. Late-onset myasthenia not on the increase: a nationwide registerstudy in Denmark, 1996-2009. Eur J Neurol 2013, 20(2):309-314. 10.1111/j.1468-1331.2012.03850.x.