Microbiological and therapeutic challenges in infectious spondylodiscitis: A cohort study of 100 cases, 2006-2011

Scandinavian Journal of Infectious Diseases

Volumn 45, Issue 6, 2013, Pages 417-424

  Aagaard, Theis ^a   Roed, Casper ^a   Dragsted, Casper ^a   Skinhøj, Peter ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Epidural abscess; Spinal infection; Spondylodiscitis; Staphylococcus aureus; Vertebral osteomyelitis

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; FUSIDIC ACID; RIFAMPICIN; RNA 16S;

ABSCESS; ADULT; AGED; ALLERGIC RASH; ANEMIA; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BLOOD CULTURE; CASE STUDY; COHORT ANALYSIS; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC VALUE; DISKITIS; DRUG HYPERSENSITIVITY; DRUG TREATMENT FAILURE; EOSINOPHILIA; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; INFECTIOUS SPONDYLODISCITIS; INTERVERTEBRAL DISK DEGENERATION; KIDNEY DISEASE; LEUKOCYTE COUNT; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; RELAPSE; RETROSPECTIVE STUDY; STAPHYLOCOCCUS INFECTION; TREATMENT DURATION;

AGED; ANTI-BACTERIAL AGENTS; DENMARK; DISCITIS; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STATISTICS, NONPARAMETRIC;

EID: 84877881853     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2012.753160     Document Type: Article

References (22)

1. Gouliouris T, A liyu SH, B rown NM. S pondylodiscitis: Update on diagnosis and management. J Antimicrob Chemother 2010; 65: Iii11-24.
2. Jensen AG, E spersen F, S kinh øj P, F rimodt-Mø l ler N. Bacteremic Staphylococcus aureus spondylitis. Arch Intern Med 1998; 158: 509-17.
3. Cottle L, R iordan T. I nfectious spondylodiscitis. J Infect 2008; 56: 401-12.
4. Zimmerli W. Clinical practice. Vertebral osteomyelitis. N Engl J Med 2010; 362: 1022-9.
5. Skaf GS, D omloj NT, F ehlings MG, B ouclaous CH, S abbagh AS, Kanafani ZA, et al. Pyogenic spondylodiscitis: An overview. J Infect Public Health 2010; 3: 5-16.
6. Bhavan K P, M arschall J, O lsen M A, F raser V J, W right N M, Warren DK. The epidemiology of hematogenous vertebral osteomyelitis: A cohort study in a tertiary care hospital. BMC Infect Dis 2010; 10: 158.
7. Mylona E, S amarkos M, K akalou E, F anourgiakis P, S koutelis A. Pyogenic vertebral osteomyelitis: A systematic review of clinical characteristics. Semin Arthritis Rheum 2009; 39: 10-7.
8. Grados F, L escure FX, S enneville E, F lipo RM, S chmit JL, Fardellone P. Suggestions for managing pyogenic (nontuberculous) discitis in adults. Joint Bone Spine 2007; 74: 133-9.
9. Bhagat S, M athieson C, J andhyala R, J ohnston R. S pondylodiscitis (disc space infection) associated with negative microbiological tests: Comparison of outcome of suspected disc space infections to documented non-tuberculous pyogenic discitis. Br J Neurosurg 2007; 21: 473-7.
10. Kourbeti IS, T siodras S, B oumpas DT. S pinal infections: Evolving concepts. Curr Opin Rheumatol 2008; 20: 471-9.
11. Roblot F, B esnier J M, J uhel L, V idal C, R agot S, B astides F, et al. Optimal duration of antibiotic therapy in vertebral osteomyelitis. Semin Arthritis Rheum 2007; 36: 269-77.
12. Colmenero J D, J imé nez-Mej í as M E, S án chez-Lora F J, Reguera JM, Palomino-Nic á s J, Martos F, et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: A descriptive and comparative study of 219 cases. Ann Rheum Dis 1997; 56: 709-15.
13. Quan H, L i B, C ouris C M, F ushimi K, G raham P, H ider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 2011; 173: 676-82.
14. Hadjipavlou A G, M ader JT, N ecessary JT, M uffoletto AJ. Hematogenous pyogenic spinal infections and their surgical management. Spine (Phila Pa 1976) 2000 ; 25: 1668-79.
15. Beronius M, B ergman B, A ndersson R. V ertebral osteomyelitis in G ö teborg, Sweden: A retrospective study of patients during 1990-95. Scand J Infect Dis 2001; 33: 527-32.
16. Lora-Tamayo J, E uba G, N arvá e z JA, M urillo O, V erdaguer R, Sobrino B, et al. Changing trends in the epidemiology of pyogenic vertebral osteomyelitis: The impact of cases with no microbiologic diagnosis. Semin Arthritis Rheum 2011; 41: 247-55.
17. Statens Statistik. Demographic evolution of the Danish population. (Only available in Danish) Denmark: Statens Statistik; 2010. Available at: http://www.dst.dk/pukora/epub/upload/ 16208/bef.pdf (accessed 5th December 2011
18. Skov R, G udlaugsson O, H ardardottir H, H arthug S, Jakobsen T, Kolmos HJ, et al. Proposal for common Nordic epidemiological terms and defi nitions for methicillin- resistant Staphylococcus aureus (MRSA). Scand J Infect Dis 2008; 40: 495-502.
19. Lecouvet F, I renge L, V andercam B, N zeusseu A, H amels S, Gala JL. The etiologic diagnosis of infectious discitis is improved by amplifi cation-based DNA analysis. Arthritis Rheum 2004; 50: 2985-94.
20. Nolla J M, A riza J, G óm ez-Vaquero C, F iter J, B ermejo J, Valverde J, et al. Spontaneous pyogenic vertebral osteomyelitis in nondrug users. Semin Arthritis Rheum 2002; 31: 271-8.
21. Pigrau C, A lmirante B, F lores X, F alco V, R odrí guez D, Gasser I, et al. Spontaneous pyogenic vertebral osteomyelitis and endocarditis: Incidence, risk factors, and outcome. Am J Med 2005; 118: 1287.
22. Premru MM, S pik VC, F urlan SL, Z upanc T L. Clinical appearance of Staphylococcus aureus spondylodiscitis and molecular characterization of the isolates. Scand J Infect Dis 2010; 42: 763-6.