Sarcopenic obesity in aging population: Current status and future directions for research

Endocrine

Volumn 45, Issue 1, 2014, Pages 15-25

  Kohara, Katsuhiko ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bioimpedance; CT; Dual energy X ray absorptiometry (DXA); Obesity; Sarcopenia

Indexed keywords

AGING; ARTERIAL STIFFNESS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FUNCTIONAL DISEASE; HIGH RISK POPULATION; HUMAN; KINESIOTHERAPY; METABOLIC SYNDROME X; MORTALITY; NUTRIENT MANAGEMENT; NUTRITIONAL HEALTH; OBESITY; PATHOPHYSIOLOGY; POPULATION RESEARCH; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SARCOPENIA; SARCOPENIC OBESITY;

AGING; BIOMEDICAL RESEARCH; EXERCISE; HUMANS; OBESITY; RISK FACTORS; SARCOPENIA; WEIGHT REDUCTION PROGRAMS;

EID: 84895910111     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-013-9992-0     Document Type: Review

References (69)

1. C. Dutta, Significance of sarcopenia in the elderly. J. Nutr. 127(5 Suppl), 992S-993S (1997)
2. J.G. Ryall, J.D. Schertzer, G.S. Lynch, Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology 9, 213-228 (2008)
3. J.M. Kinney, Nutritional frailty, sarcopenia and falls in the elderly. Curr. Opin. Clin. Nutr. Metab. Care. 7, 15-20 (2004)
4. A.J. Cruz-Jentoft, J.P. Baeyens, J.M. Bauer, Y. Boirie, T. Cederholm, F. Landi, F.C. Martin, J.P. Michel, Y. Rolland, S.M. Schneider, E. Topinková, M. Vandewoude, M. Zamboni, European working group on sarcopenia in older people. sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older people. Age. Ageing. 39, 412-423 (2010)
5. R.A. Fielding, B. Vellas, W.J. Evans, S. Bhasin, J.E. Morley, A.B. Newman, G. Abellan van Kan, S. Andrieu, J. Bauer, D. Breuille, T. Cederholm, J. Chandler, C. De Meynard, L. Donini, T. Harris, A. Kannt, F. Keime Guibert, G. Onder, D. Papanicolaou, Y. Rolland, D. Rooks, C. Sieber, E. Souhami, S. Verlaan, M. Zamboni, Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J. Am. Med. Dir. Assoc. 12, 249-256 (2011)
6. C.M. Prado, J.C. Wells, S.R. Smith, B.C. Stephan, M. Siervo, Sarcopenic obesity: a critical appraisal of the current evidence. Clin. Nutr. 31, 583-601 (2012)
7. M. Zamboni, G. Mazzali, F. Fantin, A. Rossi, V. Di Francesco, Sarcopenic obesity: a new category of obesity in the elderly. Nutr. Metab. Cardiovasc. Dis. 18, 388-395 (2008)
8. L.J. Dominguez, M. Barbagallo, The cardiometabolic syndrome and sarcopenic obesity in older persons. J. Cardiometab. Syndr. 2, 183-189 (2007)
9. S. Stenholm, T.B. Harris, T. Rantanen, M. Visser, S.B. Kritchevsky, L. Ferrucci, Sarcopenic obesity: definition, cause and consequences. Curr. Opin. Clin. Nutr. Metab. Care. 11, 693-700 (2008)
10. J.P. Gumucio, C.L. Mendias, Atrogin-1, MuRF-1, and sarcopenia. Endocrine 43, 12-21 (2013)
11. N. Mangner, Y. Matsuo, G. Schuler, V. Adams, Cachexia in chronic heart failure: endocrine determinants and treatment perspectives. Endocrine 43, 253-265 (2013)
12. A.J. Cruz-Jentoft, F. Landi, E. Topinková, J.P. Michel, Understanding sarcopenia as a geriatric syndrome. Curr. Opin. Clin. Nutr. Met. Care. 13, 1-7 (2010)
13. S.W. Park, B.H. Goodpaster, E.S. Strotmeyer, L.H. Kuller, R. Broudeau, C. Kammerer, N. de Rekeneire, T.B. Harris, A.V. Schwartz, F.A. Tylavsky, Y.W. Cho, A.B. Newman, Health, Aging, and body composition study. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care. 30, 1507-1512 (2007)
14. S.W. Park, B.H. Goodpaster, J.S. Lee, L.H. Kuller, R. Boudreau, N. de Rekeneire, T.B. Harris, S. Kritchevsky, F.A. Tylavsky, M. Nevitt, Y.W. Cho, A.B. Newman, Health, aging, and body composition study. Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care. 32, 1993-1997 (2009)
15. C.G. Lee, E.J. Boyko, E.S. Strotmeyer, C.E. Lewis, P.M. Cawthon, A.R. Hoffman, S.A. Everson-Rose, E. Barrett-Connor, E.S. Orwoll, Osteoporotic fractures in men study research group. Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. J. Am. Geriatr. Soc. 59, 1217-1224 (2011)
16. H.K. Vincent, S.N. Raiser, K.R. Vincent, The aging musculoskeletal system and obesity-related considerations with exercise. Ageing. Res. Rev. 11,361-373 (2012)
17. C.G. Lee, E.J. Boyko, E. Barrett-Connor, I. Miljkovic, A.R. Hoffman, S.A. Everson-Rose, C.E. Lewis, P.M. Cawthon, E.S. Strotmeyer, E.S. Orwoll, Osteoporotic Fractures in Men (MrOS) Study Research Group. Insulin sensitizers may attenuate lean mass loss in older men with diabetes. Diabetes Care. 34, 2381-2386 (2011)
18. P. Srikanthan, A.L. Hevener, A.S. Karlamangla, Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the national health and nutrition examination survey III. PLoS ONE 5, e10805 (2010)
19. T.N. Kim, M.S. Park, K.I. Lim, S.J. Yang, H.J. Yoo, H.J. Kang, W. Song, J.A. Seo, S.G. Kim, N.H. Kim, S.H. Baik, D.S. Choi, K.M. Choi, Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: the Korean sarcopenic obesity study (KSOS). Diabetes Res. Clin. Pract. 93, 285-291 (2011)
20. R. Oliveira, M. Bottaro, J. Junior, P. Farinatti, L. Bezerra, R. Lima, Identification of sarcopenic obesity in postmenopausal women: a cut off proposal. Braz. J. Med. Biol. Res. 44, 1171-1176 (2011)
21. T.W. Auyeung, J.S. Lee, J. Leung, T. Kwok, J. Woo, Adiposity to muscle ratio predicts incident physical limitation in a cohort of 3,153 older adults-an alternative measurement of sarcopenia and sarcopenic obesity. Age (2013) (in press)
22. R.N. Baumgartner, K.M. Koehler, D. Gallagher, L. Romero, S.B. Heymsfield, R.R. Ross, P.J. Garry, R.D. Lindeman, Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 147, 755-763 (1998)
23. R.N. Baumgartner, Body composition in healthy aging. Ann. N. Y. Acad. Sci. 904, 437-448 (2000)
24. A.B. Newman, V. Kupelian, M. Visser, E. Simonsick, B. Goodpaster, M. Nevitt, S.B. Kritchevsky, F.A. Tylavsky, S.M. Rubin, T.B. Harris, Health ABC study investigators. Sarcopenia: alternative definitions and associations with lower extremity function. J. Am. Geriatr. Soc. 51, 1602-1609 (2003)
25. R.N. Baumgartner, S.J. Wayne, D.L. Waters, I. Janssen, D. Gallagher, J.E. Morley, Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes. Res. 12, 1995-2004 (2004)
26. C.M. Prado, J.R. Lieffers, L.J. McCargar, T. Reiman, M.B. Sawyer, L. Martin, V.E. Baracos, Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 9, 629-635 (2008)
27. D.R. Bouchard, I. Janssen, Dynapenic-obesity and physical function in older adults. J. Gerontol. A Biol. Sci. Med. Sci. 65, 71-77 (2010)
28. M.E. Levine, E.M. Crimmins, The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning. Obesity 20, 2101-2106 (2012)
29. K.K. Davison, E.S. Ford, M.E. Cogswell, W.H. Dietz, Percentage of body fat and body mass index are associated with mobility limitations in people aged 70 and older from NHANES III. J. Am. Geriatr. Soc. 50, 1802-1809 (2002)
30. D.R. Bouchard, I.J. Dionne, M. Brochu, Sarcopenic/obesity and physical capacity in older men and women: data from the nutrition as a determinant of successful aging (NuAge)-the Quebec longitudinal study. Obesity 17, 2082-2088 (2009)
31. B. Sternfeld, L. Ngo, W.A. Satariano, I.B. Tager, Associations of body composition with physical performance and self-reported functional limitation in elderly men and women. Am. J. Epidemiol. 156, 110-121 (2002)
32. S. Stenholm, T. Rantanen, M. Heliovaara, S. Koskinen, The mediating role of C reactive protein and handgrip strength between obesity and walking limitation. J. Am. Geriatr. Soc. 56, 462-469 (2008)
33. Y. Rolland, V. Lauwers-Cances, C. Cristini, G. Abellan van Kan, I. Janssen, J.E. Morley, B. Vellas, Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) study. Am. J. Clin. Nutr. 89, 1895-1900 (2009)
34. M.A. Monteiro, R.C. Gabriel, M.F. Sousa, M.N. Castro, M.H. Moreira, Temporal parameters of the foot roll-over during walking: influence of obesity and sarcopenic obesity on postmenopausal women. Maturitas 67, 178-185 (2010)
35. M. Ochi, Y. Tabara, T. Kido, E. Uetani, N. Ochi, M. Igase, T. Miki, K. Kohara, Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population. Geriatr. Gerontol. Int. 10, 233-243 (2010)
36. M. Ochi, K. Kohara, Y. Tabara, T. Kido, E. Uetani, N. Ochi, M. Igase, T. Miki, Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis 212, 327-332 (2010)
37. H. Honda, A.R. Qureshi, J. Axelsson, O. Heimburger, M.E. Suliman, P. Barany, P. Stenvinkel, B. Lindholm, Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am. J. Clin. Nutr. 86, 633-638 (2007)
38. M. Cesari, S.B. Kritchevsky, R.N. Baumgartner, H.H. Atkinson, B.W. Penninx, L. Lenchik, S.L. Palla, W.T. Ambrosius, R.P. Tracy, M. Pahor, Sarcopenia, obesity, and inflammation - results from the trial of angiotensin converting enzyme inhibition and novel cardiovascular risk factors study. Am. J. Clin. Nutr. 82, 428-434 (2005)
39. A.M. Abbatecola, P. Chiodini, C. Gallo, E. Lakatta, K. Sutton-Tyrrell, F.A. Tylavsky, B. Goodpaster, N. de Rekeneire, A.V. Schwartz, G. Paolisso, T. Harris, Health ABC study. Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age 34, 469-478 (2012)
40. A. Kato, J. Ishida, Y. Endo, T. Takita, M. Furuhashi, Y. Maruyama, M. Odamaki, Association of abdominal visceral adiposity and thigh sarcopenia with changes of arteriosclerosis in haemodialysis patients. Nephrol. Dial. Transplant. 26, 1967-1976 (2011)
41. K. Kohara, M. Ochi, Y. Tabara, T. Nagai, M. Igase, T. Mik, Arterial stiffness in sarcopenic visceral obesity in the elderly: J-SHIPP study. Int. J. Cardiol. 158, 146-148 (2012)
42. H. Enoki, M. Kuzuya, Y. Masuda, Y. Hirakawa, M. Iwata, J. Hasegawa, S. Izawa, A. Iguchi, Anthropometric measurements of mid-upper arm as a mortality predictor for community-dwelling Japanese elderly: the Nagoya longitudinal study of frail elderly (NLS-FE). Clin. Nutr. 26, 597-604 (2007)
43. H. Sasaki, F. Kasagi, M. Yamada, S. Fujita, Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am. J. Med. 120, 337-342 (2007)
44. A.B. Newman, V. Kupelian, M. Visser, E.M. Simonsick, B.H. Goodpaster, S.B. Kritchevsky, F.A. Tylavsky, S.M. Rubin, T.B. Harris, Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J. Gerontol. A Biol. Sci. Med. Sci. 61, 72-77 (2006)
45. M. Cesari, M. Pahor, F. Lauretani, V. Zamboni, S. Bandinelli, R. Bernabei, J.M. Guralnik, L. Ferrucci, Skeletal muscle and mortality results from the InCHIANTI Study. J. Gerontol. A Biol. Sci. Med. Sci. 64, 377-384 (2009)
46. S. Lim, J.H. Kim, J.W. Yoon, S.M. Kang, S.H. Choi, Y.J. Park, K.W. Kim, J.Y. Lim, K.S. Park, H.C. Jang, Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean longitudinal study on health and aging (KLoSHA). Diabetes Care 33, 1652-1654 (2010)
47. K.I. Lim, S.J. Yang, T.N. Kim, H.J. Yoo, H.J. Kang, W. Song, S.H. Baik, D.S. Choi, K.M. Choi, The association between the ratio of visceral fat to thigh muscle area and metabolic syndrome: the Korean sarcopenic obesity study (KSOS). Clin. Endocrinol. 73, 588-594 (2010)
48. C.W. Lu, K.C. Yang, H.H. Chang, L.T. Lee, C.Y. Chen, K.C. Huang, Sarcopenic obesity is closely associated with metabolic syndrome. Obes. Res. Clin. Pract. (2013) (in press)
49. V. Messier, A.D. Karelis, M.E. Lavoie, M. Brochu, M. Faraj, I. Strychar, R. Rabasa-Lhoret, Metabolic profile and quality of life in class I sarcopenic overweight and obese postmenopausal women: a MONET study. Appl. Physiol. Nutr. Metabol. 34, 18-24 (2009)
50. G. Sweeney, Cardiovascular effects of leptin. Nat. Rev. Cardiol. 7, 22-29 (2010)
51. D.L. Waters, C.R. Qualls, R.I. Dorin, J.D. Veldhuis, R.N. Baumgartner, Altered growth hormone, cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes. J. Gerontol. A Biol. Sci. Med. Sci. 63, 536-541 (2008)
52. K. Kohara, M. Ochi, Y. Tabara, T. Nagai, M. Igase, T. Miki, Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes. PLoS ONE 6, e24633 (2011)
53. S.C. Forbes, J.P. Little, D.G. Candow, Exercise and nutritional interventions for improving aging muscle health. Endocrine 42, 29-38 (2012)
54. Z. Li, D. Heber, Sarcopenic obesity in the elderly and strategies for weight management. Nutr. Rev. 70, 57-64 (2012)
55. M. Jacqmain, E. Doucet, J.P. Despres, C. Bouchard, A. Tremblay, Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am. J. Clin. Nutr. 77, 1448-1452 (2003)
56. H. Shi, D. Dirienzo, M.B. Zemel, Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J. 15, 291-293 (2001)
57. M.H. Seo, M.K. Kim, S.E. Park, E.J. Rhee, C.Y. Park, W.Y. Lee, K.H. Baek, K.H. Song, M.I. Kang, K.W. Oh, The association between daily calcium intake and sarcopenia in older, non-obese Korean adults: the fourth Korea national health and nutrition examination survey (KNHANES IV) 2009. Endocr. J. (2013) (in press)
58. M.K. Kim, K.H. Baek, K.H. Song, M. Il Kang, C.Y. Park, W.Y. Lee, K.W. Oh, Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the fourth Korea national health and nutrition examination surveys (KNHANES IV) 2009. J. Clin. Endocrinol. Metab. 96, 3250-3256 (2011)
59. J.A. Seo, H. Cho, C.R. Eun, H.J. Yoo, S.G. Kim, K.M. Choi, S.H. Baik, D.S. Choi, M.H. Park, C. Han, N.H. Kim, Association between visceral obesity and sarcopenia and vitamin D deficiency in older Koreans: the Ansan Geriatric study. J. Am. Geriatr. Soc. 60, 700-706 (2012)
60. D.G. Candow, S.C. Forbes, J.P. Little, S.M. Cornish, C. Pinkoski, P.D. Chilibeck, Effect of nutritional interventions and resistance exercise on aging muscle mass and strength. Biogerontology 13, 345-358 (2012)
61. M. Aubertin-Leheudre, C. Lord, E.D. Goulet, A. Khalil, I.J. Dionne, Effect of sarcopenia on cardiovascular disease risk factors in obese postmenopausal women. Obesity 14, 2277-2283 (2006)
62. P. Alexandersen, L.B. Tanko, Y.Z. Bagger, J. Jespersen, S.O. Skouby, C. Christiansen, Associations between aortic calcification and components of body composition in elderly men. Obesity 14, 1571-1578 (2006)
63. M.A. Schrager, E.J. Metter, E. Simonsick, A. Ble, S. Bandinelli, F. Lauretani, L. Ferrucci, Sarcopenic obesity and inflammation in the InCHIANTI study. J. Appl. Physiol. 102, 919-925 (2007)
64. Y.S. Kim, Y. Lee, Y.S. Chung, D.J. Lee, N.S. Joo, D. Hong, G.E. Song, H.J. Kim, Y.J. Choi, K.M. Kim, Prevalence of sarcopenia and sarcopenic obesity in the Korean population based on the fourth Korean national health and nutritional examination surveys. J. Gerontol. A Biol. Sci. Med. Sci. 67, 1013-1107 (2012)
65. M. Siervo, B.C.M. Stephan, G. Nasti, A. Colantuoni, Ageing adiposity indexes and low muscle mass in a clinical sample of overweight and obese women. Obes. Res. Clin. Pract. 6, e63-70 (2012)
66. M. Visser, L.M. van Venrooij, L. Vulperhorst, R. de Vos, W. Wisselink, P.A. van Leeuwen, B.A. de Mol, Sarcopenic obesity is associated with adverse clinical outcome after cardiac surgery. Nutr. Metab. Cardiovasc. Dis. (2013) (in press)
67. T. Schutz, H. Hudjetz, A.E. Roske, C. Katzorke, G. Kreymann, K. Budde, L. Fritsche, H.H. Neumayer, H. Lochs, M. Plauth, Weight gain in long-term survivors of kidney or liver transplantation - another paradigm of sarcopenic obesity? Nutrition 28, 378-383 (2012)
68. S. Barbat-Artigas, M.E. Filion, S. Plouffe, M. Aubertin-Leheudre, Muscle quality as a potential explanation of the metabolically healthy but obese and sarcopenic obese paradoxes. Metab. Syndr. Relat. Disord. 10, 117-122 (2010)
69. S. Stenholm, D. Alley, S. Bandinelli, M.E. Griswold, S. Koskinen, T. Rantanen, J.M. Guralnik, L. Ferrucci, The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. Int. J. Obes. 33, 635-644 (2009)