Immunohistochemical actinin-4 expression in infiltrating gliomas: Association with WHO grade and differentiation

Brain Tumor Pathology

Volumn 31, Issue 1, 2014, Pages 11-16

  Fukushima, Shintaro ^a,b   Yoshida, Akihiko ^a   Honda, Kazufumi ^b   Maeshima, Akiko Miyagi ^a   Narita, Yoshitaka ^a   Yamada, Tesshi ^b   Shibui, Soichiro ^a   Tsuda, Hitoshi ^a  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Actinin 4; Differentiation; Immunohistochemistry; Infiltrating glioma; WHO grade

Indexed keywords

ACTININ 4; KI 67 ANTIGEN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTROCYTOMA; CANCER GRADING; CANCER GROWTH; CANCER INFILTRATION; CLINICAL ARTICLE; CLINICAL EVALUATION; DISEASE ASSOCIATION; FEMALE; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OLIGODENDROGLIOMA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION;

ACTININ; ADULT; AGED; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM STAGING; STAINING AND LABELING; TUMOR CELLS, CULTURED; WORLD HEALTH ORGANIZATION;

EID: 84895861976     PISSN: 14337398     EISSN: 1861387X     Source Type: Journal    
DOI: 10.1007/s10014-013-0139-z     Document Type: Article

References (20)

1. The Committee of Brain Tumor Registry of Japan (2009) Report of brain tumor registry of Japan (1984-2000), 12th edn. Neurol Med Chir (Tokyo) 49:1-101
2. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) WHO classification of tumours of the central nervous system. 4th edn. International Agency for Research on Cancer (IARC), Lyon
3. Partin AW, Schoeniger JS, Mohler JL, Coffey DS (1989) Fourier analysis of cell motility: correlation of motility with metastatic potential. Proc Natl Acad Sci 86:1254-1258 (Pubitemid 19061525)
4. Gonzalez AM, Otey C, Edlund M, Jones JC (2001) Interactions of a hemidesmosome component and actinin family members. J Cell Sci 114:4197-4206 (Pubitemid 33138657)
5. Honda K, Yamada T, Endo R, Ino Y, Gotoh M, Tsuda H, Yamada Y, Chiba H, Hirohashi S (1998) Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol 140:1383-1393 (Pubitemid 28152987)
6. Honda K, Yamada T, Hayashida Y, Idogawa M, Sato S, Hasegawa F, Ino Y, Ono M, Hirohashi S (2005) Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology 128:51-62 (Pubitemid 40039958)
7. Honda K, Yamada T, Seike M, Hayashida Y, Idogawa M, Kondo T, Ino Y, Hirohashi S (2004) Alternative splice variant of actinin-4 in small cell lung cancer. Oncogene 23:5257-5262 (Pubitemid 38980358)
8. Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J, Hirohashi S, Yamada T (2008) Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res 14:5348-5356
9. Welsch T, Keleg S, Bergmann F, Bauer S, Hinz U, Schmidt J (2009) Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma. Pancreas 38:968-976
10. Yamamoto S, Tsuda H, Honda K, Kita T, Takano M, Tamai S, Inazawa J, Yamada T, Matsubara O (2007) Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod Pathol 20:1278-1285 (Pubitemid 350126853)
11. Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O (2009) Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol 22:499-507
12. Henry WI, Dubois J, Quick QA (2011) The microtubule inhibiting agent epothilone B antagonizes glioma cell motility associated with reorganization of the actin-binding protein alphaactinin 4. Oncol Rep 25:887-893
13. Quick Q, Skalli O (2010) Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. Exp Cell Res 316:1137-1147
14. Sen S, Dong M, Kumar S (2009) Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS ONE 4:e8427
15. Eigenbrod S, Roeber S, Thon N, Giese A, Krieger A, Grasbon-Frodl E, Egensperger R, Tonn JC, Kreth FW, Kretzschmar HA (2011) Alpha-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status. J Neuropathol Exp Neurol 70:970-978
16. Ducray F, Criniere E, Idbaih A, Mokhtari K, Marie Y, Paris S, Navarro S, Laigle-Donadey F, Dehais C, Thillet J, Hoang-Xuan K, Delattre JY, Sanson M (2009) a-Internexin expression identifies 1p19q codeleted gliomas. Neurology 72:156-161
17. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, Rodriguez-Perez JC, Allen PG, Beggs AH, Pollak MR (2000) Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24:251-256 (Pubitemid 30132192)
18. Griffin CA, Burger P, Morsberger L, Yonescu R, Swierczynski S, Weingart JD, Murphy KM (2006) Identification of der(1;19) (q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. J Neuropathol Exp Neurol 65:988-994 (Pubitemid 44521799)
19. Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP (1994) Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol 145:1175-1190 (Pubitemid 24345665)
20. Rong Y, Durden DL, Van Meir EG, Brat DJ (2006) 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65:529-539 (Pubitemid 44288937)