The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development

Journal of the Formosan Medical Association

Volumn 113, Issue 3, 2014, Pages 143-147

  Zhou, Nan ^a   Zhang, Yun ^a   Zhang, Jin Chun ^a   Feng, Ling ^a   Bao, Jin Ku ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Coronavirus; Drug design; Middle east; Vaccines

Indexed keywords

VACCINE;

CORONAVIRUS; CORONAVIRUS INFECTION; CRYSTAL STRUCTURE; GLUCOSE METABOLISM; HUMAN; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MORTALITY; NONHUMAN; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SARS CORONAVIRUS;

CORONAVIRUS; DRUG DESIGN; MIDDLE EAST; VACCINES;

ANTIVIRAL AGENTS; CORONAVIRUS; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; DRUG DESIGN; HUMANS; RECEPTORS, VIRUS; VIRAL VACCINES;

EID: 84895861186     PISSN: None     EISSN: 09296646     Source Type: Journal    
DOI: 10.1016/j.jfma.2013.11.006     Document Type: Review

References (34)

1. Khan G. A novel coronavirus capable of lethal human infections: an emerging picture. Virol J 2013, 10:66. [Abstract].
2. Lu L., Liu Q., Du L., Jiang S. Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread. Microbes Infect 2013, 15:625-629.
3. Middle East respiratory syndrome coronavirus (MERS-CoV)-update 2013, World Health Organization, WHO, Geneva, [accessed 15.09.13]. http://www.who.int/csr/don/2013_09_07/en/index.html.
4. Chan J.F.-W., Lau S.K.-P., Woo P.C.-Y. The emerging novel Middle East respiratory syndrome coronavirus: the "knowns" and "unknowns". J Formosan Med Assoc 2013, 112:372-381.
5. Summary table of SARS cases by country, 1 November 2002-7 August 2003 2003, World Health Organization, WHO, Geneva, [accessed 15.09.13]. http://www.who.int/csr/sars/country/2003_08_15/en/.
6. Guery B., Poissy J., el Mansouf L., Séjourné C., Ettahar N., Lemaire X., et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet 2013, 381:2265-2272.
7. Memish Z.A., Zumla A.I., Al-Hakeem R.F., Al-Rabeeah A.A., Stephens G.M. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 2013, 368:2487-2494.
8. Assiri A., McGeer A., Perl T.M., Price C.S., Al Rabeeah A.A., Cummings D.A.T., et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013, 369:407-416.
9. Woo P.C., Lau S.K., Lam C.S., Lau C.C., Tsang A.K., Lau J.H., et al. Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J Virol 2012, 86:3995-4008.
10. Virus taxonomy: 2012 release 2012, International Committee on Taxonomy of Viruses, ICTV, Leuven, [accessed 15.09.13]. http://ictvonline.org/virusTaxonomy.asp?versionZ2012.
11. Woo P.C., Lau S.K., Huang Y., Yuen K.-Y. Coronavirus diversity, phylogeny and interspecies jumping. Exp Biol Med 2009, 234:1117-1127.
12. Lu G., Liu D. SARS-like virus in the Middle East: a truly bat-related coronavirus causing human diseases. Protein Cell 2012, 3:803-805.
13. Raj V.S., Mou H., Smits S.L., Dekkers D.H., Müller M.A., Dijkman R., et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013, 495:251-254.
14. Jiang S., Lu L., Du L., Debnath A.K. A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC. J Infect 2013, 66:464-466.
15. Lu G., Hu Y., Wang Q., Qi J., Gao F., Li Y., et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 2013, 500:227-231.
16. Du L., He Y., Zhou Y., Liu S., Zheng B.-J., Jiang S. The spike protein of SARS-CoV-a target for vaccine and therapeutic development. Nat Rev Microbiol 2009, 7:226-236.
17. Chen Y., Rajashankar K.R., Yang Y., Agnihothram S.S., Liu C., Lin Y.-L., et al. Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. J Virol 2013, 87:10777-10783.
18. Mou H., Raj V.S., van Kuppeveld F.J., Rottier P.J., Haagmans B.L., Bosch B.J. The receptor binding domain of the new MERS coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies. J Virol 2013, 87:9379-9383.
19. Du L., Zhao G., Kou Z., Ma C., Sun S., Poon V.K., et al. Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development. J Virol 2013, 87:9939-9942.
20. Wang N., Shi X., Jiang L., Zhang S., Wang D., Tong P., et al. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res 2013, 23:986-993.
21. Stivala A., Wybrow M., Wirth A., Whisstock J.C., Stuckey P.J. Automatic generation of protein structure cartoons with Pro-origami. Bioinformatics 2011, 27:3315-3316.
22. Gorrell M., Gysbers V., McCaughan G. CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol 2001, 54:249-264.
23. Boonacker E., Van Noorden C.J. The multifunctional or moonlighting protein CD26/DPPIV. Eur J Cell Biol 2003, 82:53-73.
24. Lambeir A.-M., Durinx C., Scharpé S., De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 2003, 40:209-294.
25. Engel M., Hoffmann T., Wagner L., Wermann M., Heiser U., Kiefersauer R., et al. The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A 2003, 100:5063-5068.
26. Rasmussen H.B., Branner S., Wiberg F.C., Wagtmann N. Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog. Nat Struct Mol Biol 2002, 10:19-25.
27. Bosch B.J., Raj V.S., Haagmans B.L. Spiking the MERS-coronavirus receptor. Cell Res 2013, 23:1069-1070.
28. He Y., Zhu Q., Liu S., Zhou Y., Yang B., Li J., et al. Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines. Virology 2005, 334:74-82.
29. Zhu X., Liu Q., Du L., Lu L., Jiang S. Receptor-binding domain as a target for developing SARS vaccines. J Thorac Dis 2013, 5(Suppl. 2):S142-S148.
30. Irwin J.J., Sterling T., Mysinger M.M., Bolstad E.S., Coleman R.G. ZINC: A free tool to discover chemistry for biology. J Chem Inf Model 2012, 52:1757-1768.
31. Wang Y., Xiao J., Suzek T.O., Zhang J., Wang J., Bryant S.H. PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res 2009, 37(Suppl. 2):W623-W633.
32. Knox C., Law V., Jewison T., Liu P., Ly S., Frolkis A., et al. DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs. Nucleic Acids Res 2011, 39:D1035-D1041.
33. Weisel M., Proschak E., Schneider G. PocketPicker: analysis of ligand binding-sites with shape descriptors. Chem Cent J 2007, 1:1-17.
34. Bennet N. Alarm bells over MERS coronavirus. Lancet Infect Dis 2013, 13:573-574.