Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in sprague-dawley rats

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  He, Yudong D ^a   Karbowski, Christine M ^b   Werner, Jon ^b   Everds, Nancy ^a   Di Palma, Chris ^a   Chen, Yuan ^b   Higgins Garn, Marnie ^b   Tran, Sandra ^b   Afshari, Cynthia A ^b   Hamadeh, Hisham K ^b  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CALPAIN 1; COMPLEMENT COMPONENT C4 BINDING PROTEIN; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C9; CORTICOSTERONE; CYCLIN D3; CYCLIN G1; CYCLINE; GLUTAMATE DEHYDROGENASE; GLUTATHIONE SYNTHASE; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; JUNCTIONAL ADHESION MOLECULE; PROTEIN BAX; SERINE PROTEINASE OMI; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BAG1 GENE; BAX GENE; C4BPA GENE; C5 GENE; C9 GENE; CAPNS1 GENE; CCND3 GENE; CCNG1 GENE; CCRL1 GENE; CD7 GENE; CFB GENE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CUL1 GENE; CXCL12 GENE; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC IDENTIFICATION; GSS GENE; GSTM4 GENE; GSTP1 GENE; HLA C GENE; HMOX1 GENE; HTRA2 GENE; ICAM1 GENE; IL1A GENE; IN VIVO STUDY; JAM2 GENE; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PCNA GENE; PERP GENE; PSMD9 GENE; RAT; SPRAGUE DAWLEY RAT; TGFBR1 GENE; THROMBOCYTE COUNT; UBE2V1 GENE; UCHL3 GENE;

ANIMAL EXPERIMENTATION; ANIMALS; ARTIFACTS; BLOOD SPECIMEN COLLECTION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MODELS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; SIGNAL TRANSDUCTION;

EID: 84895804225     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088750     Document Type: Article

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