Effects of 3β-double salicyloyl diosgenin on infarct volume and PI3K/Akt signal path in rats with focal cerebral ischemia/reperfusion injury

Chinese Pharmacological Bulletin

Volumn 29, Issue 12, 2013, Pages 1672-1675

  Wang, Chun Yan ^a   Huang, Ping ^b   Zhang, Zhen Hua ^c  

^a Shanghai Antu Hospital   (China)

^b Dept of Internal Medicine Yanji Community Health Service Centre of Yangpu District   (China)

^c Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Apoptosis; Diosgenin; Infarct volume; MCAO model; Tocal cerebral ischemia reperfusion injury

Indexed keywords

3BETA DOUBLE SALICYLOYL DIOSGENIN; CASPASE 3; DIOSGENIN; EOSIN; HEMATOXYLIN; NIMODIPINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN SIZE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; FOCAL CEREBRAL ISCHEMIA; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NISSL STAINING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SHAM PROCEDURE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84895799092     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1001-1978.2013.12.011     Document Type: Article

References (12)

1. Xing B, Chen H, Zhang M, et al. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in therat[J]. Stroke, 2008,39(8):2362-9.
2. Chaitanya G V, Schwaninger M, Alexander J S, Babu P P. Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemiain rat model.[J]. Neuroscience, 2010,17,165(4):1203-16.
3. Wang G J, Zhang B, Zhang X S, et al. The effect of Dioscin and borneol in treatment with cerebral ischemic of rats induced by MCAO[J]. Pharmacol Clin Chin Mater Med, 201,24(4):224-8.
4. Balogun E, Hoque M, Gong P F, et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant responsive element[J]. Biochem J, 2003,371:887-95. (Pubitemid 36578887)
5. Velmurugan K, Alam J, McCord J M, et al. Synergistic induction of hemeoxygenase-1 by the components of the antioxidant supplement protandim[J]. Free Radic Biol Med, 2009,46(3):430-40.
6. Nishinaka T, Ichijo Y, Ito M, et al. Curcumin activates human glutathione S-transferase PI expression through antioxidant response element[J]. Toxicol Let, 2007,170:238-47 (Pubitemid 46710275)
7. Visavadiya N P, Narasimhacharya A V. Asparagus root regulates cholesterol metabolism and improves antioxidant status inhypercholesteremic rats[J]. Evid Based Complement Alternat Med, 2009,6(2):219-26.
8. Tu X K, Yang W Z, Shi S S, et al. Baicalin inhibits TLR2 /4 signaling pathway in rat brain following permanent cerebral ischemia[J]. Inflammation, 2011,34(5)463-74.
9. Latanich C A, Toledo-Pereyra L H. Searching for NF-κB-based treatments of ischemia reperfusion injury[J]. J Invest Surg, 2009,22(4):301-15.
10. 3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats[J]. J Cereb Blood Flow Met, 2007,27:521-33.
11. Song X Y, Hu J F, Chen N H. The apoptosis of nerve cells and ischemic cerebrovascular disease[J]. Chin Pharmacol Bull, 2012,28(3):307-10.
12. Yang C, Zhang X, Fan H, Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains againstfocal ischemia[J]. Brain Res, 2009,28,1282:133-41.