Multiparametric PET/CT-perfusion does not add significant additional information for initial staging in lung cancer compared with standard PET/CT

EJNMMI Research

Volumn 4, Issue 1, 2014, Pages 1-13

  Huellner, Martin W ^a,d   Collen, Timothy D ^a   Gut, Philipp ^a   Winterhalder, Ralph ^a   Pauli, Chantal ^b,d   Diebold, Joachim ^b   Seifert, Burkhardt ^c   Strobel, Klaus ^a   Veit Haibach, Patrick ^a,d  

^a LUZERNER KANTONSSPITAL   (Switzerland)

^b Pathologische Institut am Kantonsspital Luzern   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

CT perfusion; FDG PET CT; Functional imaging; Lung cancer; Multimodality imaging

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADENOCARCINOMA; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BLOOD FLOW; BLOOD VOLUME; BODY WEIGHT; CANCER STAGING; CAPILLARY DENSITY; CHEMORADIOTHERAPY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED EMISSION TOMOGRAPHY PERFUSION; DIAGNOSTIC TEST ACCURACY STUDY; DRUG UPTAKE; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; LARGE CELL CARCINOMA; LUNG CANCER; LUNG NON SMALL CELL CANCER; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIODIAGNOSIS; SQUAMOUS CELL CARCINOMA; TUMOR VOLUME;

EID: 84895798828     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/2191-219X-4-6     Document Type: Article

References (46)

1. Ezzati M, Henley SJ, Lopez AD, Thun MJ: Role of smoking in global and regional cancer epidemiology: current patterns and data needs. Int J Cancer 2005, 116:963-971.
2. Ezzati M, Lopez AD: Estimates of global mortality attributable to smoking in 2000. Lancet 2003, 362:847-852.
3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
4. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, Gareen IF, Gatsonis C, Marcus PM, Sicks JD: Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011, 365:395-409.
5. Sone S, Li F, Yang ZG, Honda T, Maruyama Y, Takashima S, Hasegawa M, Kawakami S, Kubo K, Haniuda M, Yamanda T: Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer 2001, 84:25-32.
6. Swensen SJ, Jett JR, Hartman TE, Midthun DE, Sloan JA, Sykes AM, Aughenbaugh GL, Clemens MA: Lung cancer screening with CT: Mayo Clinic experience. Radiology 2003, 226:756-761.
7. Weidner N: Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995, 36:169-180.
8. Aggarwal C, Somaiah N, Simon G: Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed? Cancer Biol Ther 2012, 13:247-263.
9. Saijo N: Present status and problems on molecular targeted therapy of cancer. Cancer Res Treat 2012, 44:1-10.
10. Stevenson JP, Rosen M, Sun W, Gallagher M, Haller DG, Vaughn D, Giantonio B, Zimmer R, Petros WP, Stratford M, Chaplin D, Young SL, Schnall M, O'Dwyer PJ: Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 2003, 21:4428-4438.
11. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004, 10:145-147.
12. Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R: Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience. Radiology 2011, 259:574-582.
13. Wang J, Wu N, Cham MD, Song Y: Tumor response in patients with advanced non-small cell lung cancer: perfusion CT evaluation of chemotherapy and radiation therapy. AJR Am J Roentgenol 2009, 193:1090-1096.
14. Yabuuchi H, Hatakenaka M, Takayama K, Matsuo Y, Sunami S, Kamitani T, Jinnouchi M, Sakai S, Nakanishi Y, Honda H: Non-small cell lung cancer: detection of early response to chemotherapy by using contrastenhanced dynamic and diffusion-weighted MR imaging. Radiology 2011, 261:598-604.
15. 18F-FDG PET/CT and volume perfusion CT in primary tumours and mediastinal lymph nodes of non-small-cell lung cancer. Eur J Nucl Med Mol Imaging 2013, 40:677-684.
16. Sauter AW, Winterstein S, Spira D, Hetzel J, Schulze M, Mueller M, Pfannenberg C, Claussen CD, Klotz E, Hann von Weyhern C, Horger MS: Multifunctional profiling of non-small cell lung cancer using 18F-FDG PET/CT and volume perfusion CT. J Nucl Med 2012, 53:521-529.
17. Ng CS, Chandler AG, Wei W, Anderson EF, Herron DH, Charnsangavej C, Kurzrock R: Reproducibility of perfusion parameters obtained from perfusion CT in lung tumors. AJR Am J Roentgenol 2011, 197:113-121.
18. Goh V, Halligan S, Gharpuray A, Wellsted D, Sundin J, Bartram CI: Quantitative assessment of colorectal cancer tumor vascular parameters by using perfusion CT: influence of tumor region of interest. Radiology 2008, 247:726-732.
19. Rodgers J, Nicewander W: Thirteen ways to look at the correlation coefficient. JSTOR 1988, 41:59-66.
20. Goh V, Halligan S, Wellsted DM, Bartram CI: Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study. Eur Radiol 2009, 19:79-89.
21. Li SP, Makris A, Gogbashian A, Simcock IC, Stirling JJ, Goh V: Predicting response to neoadjuvant chemotherapy in primary breast cancer using volumetric helical perfusion computed tomography: a preliminary study. Eur Radiol 2012, 22:1871-1880.
22. Park MS, Klotz E, Kim MJ, Song SY, Park SW, Cha SW, Lim JS, Seong J, Chung JB, Kim KW: Perfusion CT: noninvasive surrogate marker for stratification of pancreatic cancer response to concurrent chemo-and radiation therapy. Radiology 2009, 250:110-117.
23. Dunnwald LK, Gralow JR, Ellis GK, Livingston RB, Linden HM, Specht JM, Doot RK, Lawton TJ, Barlow WE, Kurland BF, Schubert EK, Mankoff DA: Tumor metabolism and blood flow changes by positron emission tomography: relation to survival in patients treated with neoadjuvant chemotherapy for locally advanced breast cancer. J Clin Oncol 2008, 26:4449-4457.
24. Specht JM, Kurland BF, Montgomery SK, Dunnwald LK, Doot RK, Gralow JR, Ellis GK, Linden HM, Livingston RB, Allison KH, Schubert EK, Mankoff DA: Tumor metabolism and blood flow as assessed by positron emission tomography varies by tumor subtype in locally advanced breast cancer. Clin Cancer Res 2010, 16:2803-2810.
25. Tseng J, Dunnwald LK, Schubert EK, Link JM, Minoshima S, Muzi M, Mankoff DA: 18F-FDG kinetics in locally advanced breast cancer: correlation with tumor blood flow and changes in response to neoadjuvant chemotherapy. J Nucl Med 2004, 45:1829-1837.
26. Komar G, Kauhanen S, Liukko K, Seppanen M, Kajander S, Ovaska J, Nuutila P, Minn H: Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res 2009, 15:5511-5517.
27. Miles KA, Griffiths MR, Keith CJ: Blood flow-metabolic relationships are dependent on tumour size in non-small cell lung cancer: a study using quantitative contrast-enhanced computer tomography and positron emission tomography. Eur J Nucl Med Mol Imaging 2006, 33:22-28.
28. Schmid-Bindert G, Henzler T, Chu TQ, Meyer M, Nance JW Jr, Schoepf UJ, Dinter DJ, Apfaltrer P, Krissak R, Manegold C, Schoenberg SO, Fink C: Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PET-CT? Eur Radiol 2012, 22:93-103.
29. Ippolito D, Capraro C, Guerra L, De Ponti E, Messa C, Sironi S: Feasibility of perfusion CT technique integrated into conventional 18FDG/PET-CT studies in lung cancer patients: clinical staging and functional information in a single study. Eur J Nucl Med Mol Imaging 2012, 40(2):156-165.
30. Rajendran JG, Mankoff DA, O'Sullivan F, Peterson LM, Schwartz DL, Conrad EU, Spence AM, Muzi M, Farwell DG, Krohn KA: Hypoxia and glucose metabolism in malignant tumors: evaluation by [18 F]fluoromisonidazole and [18 F]fluorodeoxyglucose positron emission tomography imaging. Clin Cancer Res 2004, 10:2245-2252.
31. Padhani AR, Miles KA: Multiparametric imaging of tumor response to therapy. Radiology 2010, 256:348-364.
32. Hockel M, Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001, 93:266-276.
33. Li M, Wu N, Zheng R, Liang Y, Liu Y, Zhang W, Li N, Zhao P: Primary tumor PET/CT [(1)(8)F]FDG uptake is an independent predictive factor for regional lymph node metastasis in patients with non-small cell lung cancer. Cancer Imaging 2013, 12:566-572.
34. Kiessling F, Boese J, Corvinus C, Ederle JR, Zuna I, Schoenberg SO, Brix G, Schmahl A, Tuengerthal S, Herth F, Kauczor HU, Essig M: Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring? Eur Radiol 2004, 14:1226-1233.
35. Cappabianca S, Porto A, Petrillo M, Greco B, Reginelli A, Ronza F, Setola F, Rossi G, Di Matteo A, Muto R, De Rimini ML, Piccolo S, Catalano M, Muto P, De Rosa N, Barra E, De Rosa I, Antinolfi F, Antinolfi G, Caputi M, Brunese L, Grassi R, Rotondo A: Preliminary study on the correlation between grading and histology of solitary pulmonary nodules and contrast enhancement and [18 F]fluorodeoxyglucose standardised uptake value after evaluation by dynamic multiphase CT and PET/CT. J Clin Pathol 2011, 64:114-119.
36. Li Y, Yang ZG, Chen TW, Chen HJ, Sun JY, Lu YR: Peripheral lung carcinoma: correlation of angiogenesis and first-pass perfusion parameters of 64-detector row CT. Lung Cancer 2008, 61:44-53.
37. Mineo TC, Ambrogi V, Baldi A, Rabitti C, Bollero P, Vincenzi B, Tonini G: Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer. J Clin Pathol 2004, 57:591-597.
38. Kohler HH, Barth PJ, Siebel A, Gerharz EW, Bittinger A: Quantitative assessment of vascular surface density in renal cell carcinomas. Br J Urol 1996, 77:650-654.
39. Swensen SJ, Brown LR, Colby TV, Weaver AL, Midthun DE: Lung nodule enhancement at CT: prospective findings. Radiology 1996, 201:447-455.
40. Tateishi U, Nishihara H, Watanabe S, Morikawa T, Abe K, Miyasaka K: Tumor angiogenesis and dynamic CT in lung adenocarcinoma: radiologicpathologic correlation. J Comput Assist Tomogr 2001, 25:23-27.
41. Goh V, Rodriguez-Justo M, Engledow A, Shastry M, Endozo R, Peck J, Meagher M, Taylor SA, Halligan S, Groves AM: Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method. Eur Radiol 2012, 22:1687-1692.
42. Weidner N: Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 1995, 147:9-19.
43. Hansen S, Grabau DA, Rose C, Bak M, Sorensen FB: Angiogenesis in breast cancer: a comparative study of the observer variability of methods for determining microvessel density. Lab Invest 1998, 78:1563-1573.
44. Vermeulen PB, Libura M, Libura J, O'Neill PJ, van Dam P, Van Marck E, Van Oosterom AT, Dirix LY: Influence of investigator experience and microscopic field size on microvessel density in node-negative breast carcinoma. Breast Cancer Res Treat 1997, 42:165-172.
45. Ng QS, Goh V, Fichte H, Klotz E, Fernie P, Saunders MI, Hoskin PJ, Padhani AR: Lung cancer perfusion at multi-detector row CT: reproducibility of whole tumor quantitative measurements. Radiology 2006, 239:547-553.
46. Ng QS, Goh V, Klotz E, Fichte H, Saunders MI, Hoskin PJ, Padhani AR: Quantitative assessment of lung cancer perfusion using MDCT: does measurement reproducibility improve with greater tumor volume coverage? AJR Am J Roentgenol 2006, 187:1079-1084.