Serum immunoglobulin M concentration is positively related to metabolic syndrome in an adult population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Song, Kun ^a   Du, Huanmin ^a   Zhang, Qing ^a   Wang, Chongjin ^a   Guo, Yinting ^a   Wu, Hongmei ^a   Liu, Li ^a   Jia, Qiyu ^a   Wang, Xing ^a   Shi, Hongbin ^a   Sun, Shaomei ^a   Niu, Kaijun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHINA; CHOLESTEROL BLOOD LEVEL; CHRONIC INFLAMMATION; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; FAMILY HISTORY; FEMALE; HIGH RISK POPULATION; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNONEPHELOMETRY; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; METABOLIC SYNDROME X; PREDICTIVE VALUE; PREVALENCE; PROTEIN FUNCTION; RISK ASSESSMENT; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; UNIVERSITY HOSPITAL; WAIST CIRCUMFERENCE; ANTHROPOMETRY; AUTOIMMUNITY; BLOOD; BLOOD PRESSURE; INFLAMMATION; MASS SPECTROMETRY; MIDDLE AGED; RISK; RISK FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTHROPOMETRY; AUTOIMMUNITY; BLOOD PRESSURE; BODY MASS INDEX; CHINA; CHOLESTEROL, HDL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN M; INFLAMMATION; MALE; MASS SPECTROMETRY; METABOLIC SYNDROME X; MIDDLE AGED; ODDS RATIO; PREVALENCE; RISK FACTORS; TRIGLYCERIDES;

EID: 84895734253     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088701     Document Type: Article

References (35)

1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, et al. (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 2095-2128.
2. Grundy SM (2008) Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28: 629-636.
3. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, et al. (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107: 499-511. (Pubitemid 36158056)
4. Jenny NS (2012) Inflammation in aging: cause, effect, or both? Discov Med 13: 451-460.
5. Kamp DW, Shacter E, Weitzman SA (2011) Chronic inflammation and cancer: the role of the mitochondria. Oncology (Williston Park) 25: 400-410, 413.
6. Romeo GR, Lee J, Shoelson SE (2012) Metabolic syndrome, insulin resistance, and roles of inflammation - mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32: 1771-1776.
7. Nathan C (2008) Epidemic inflammation: pondering obesity. Mol Med 14: 485-492.
8. Calabro P, Golia E, Maddaloni V, Malvezzi M, Casillo B, et al. (2009) Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease? Intern Emerg Med 4: 25-34.
9. Nikolopoulou A, Kadoglou NP (2012) Obesity and metabolic syndrome as related to cardiovascular disease. Expert Rev Cardiovasc Ther 10: 933-939.
10. Sun S, Ji Y, Kersten S, Qi L (2012) Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr 32: 261-286.
11. Marti A, Marcos A, Martinez JA (2001) Obesity and immune function relationships. Obes Rev 2: 131-140. (Pubitemid 33755922)
12. Sell H, Eckel J (2010) Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care 13: 366-370.
13. Winer DA, Winer S, Shen L, Wadia PP, Yantha J, et al. (2011) B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17: 610-617.
14. Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, et al. (2013) Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep 3: 1187-1198.
15. Ehrenstein MR, Notley CA (2010) The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol 10: 778-786.
16. Vollmers HP, Brandlein S (2006) Natural IgM antibodies: the orphaned molecules in immune surveillance. Adv Drug Deliv Rev 58: 755-765. (Pubitemid 44247229)
17. Duarte-Rey C, Bogdanos DP, Leung PS, Anaya JM, Gershwin ME (2012) IgM predominance in autoimmune disease: genetics and gender. Autoimmun Rev 11: A404-412.
18. Marchalonis JJ, Schluter SF, Wilson L, Yocum DE, Boyer JT, et al. (1993) Natural human antibodies to synthetic peptide autoantigens: correlations with age and autoimmune disease. Gerontology 39: 65-79. (Pubitemid 23145789)
19. Licata G, Argano C, Di Chiara T, Parrinello G, Scaglione R (2006) Obesity: a main factor of metabolic syndrome? Panminerva Med 48: 77-85. (Pubitemid 44671263)
20. Shirai K (2004) Obesity as the core of the metabolic syndrome and the management of coronary heart disease. Curr Med Res Opin 20: 295-304.
21. Gonzalez-Quintela A, Alende R, Gude F, Campos J, Rey J, et al. (2008) Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities. Clin Exp Immunol 151: 42-50. (Pubitemid 350230994)
22. Tianjin Municipal Government (2007) About Tianjin. Available: http://www.tj.gov.cn/english/About-tianjin/Visiting-Tianjin/. Accessed 2013 Aug 5.
23. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
24. Marzullo P, Minocci A, Giarda P, Marconi C, Tagliaferri A, et al. (2013) Lymphocytes and immunoglobulin patterns across the threshold of severe obesity. Endocrine.
25. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830. (Pubitemid 38063705)
26. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025. (Pubitemid 44684486)
27. Kovanen PT, Manttari M, Palosuo T, Manninen V, Aho K (1998) Prediction of myocardial infarction in dyslipidemic men by elevated levels of immunoglobulin classes A, E, and G, but not M. Arch Intern Med 158: 1434-1439. (Pubitemid 28317759)
28. Bouman A, Heineman MJ, Faas MM (2005) Sex hormones and the immune response in humans. Hum Reprod Update 11: 411-423. (Pubitemid 40895468)
29. Kolovou GD, Anagnostopoulou KK, Salpea KD, Mikhailidis DP (2007) The prevalence of metabolic syndrome in various populations. Am J Med Sci 333: 362-371. (Pubitemid 46945477)
30. Gleicher N, Barad DH (2007) Gender as risk factor for autoimmune diseases. J Autoimmun 28: 1-6. (Pubitemid 46274179)
31. Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W (2008) Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev 7: 579-584.
32. Knudsen GP (2009) Gender bias in autoimmune diseases: X chromosome inactivation in women with multiple sclerosis. J Neurol Sci 286: 43-46.
33. Maury E, Brichard SM (2010) Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 314: 1-16.
34. Elks CM, Francis J (2010) Central adiposity, systemic inflammation, and the metabolic syndrome. Curr Hypertens Rep 12: 99-104.
35. Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, et al. (2007) Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27: 84-91. (Pubitemid 46370478)