Management of hypotension in preterm infants (The HIP Trial): A randomised controlled trial of hypotension management in extremely low gestational age newborns

Neonatology

Volumn 105, Issue 4, 2014, Pages 275-281

  Dempsey, E M ^a   Barrington, K J ^e   Marlow, N ^g   O'Donnell, C P ^b   Miletin, J ^c   Naulaers, G ^h   Cheung, P Y ^f   Corcoran, D ^d   Pons, G ^j   Stranak, Z ^k   Van Laere, D ⁱ  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b NATIONAL MATERNITY HOSPITAL   (Ireland)

^c Tallaght and Coombe Women's and Infant's University Hospital   (Ireland)

^d ROTUNDA HOSPITAL   (Ireland)

^e UNIVERSITY OF MONTREAL   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF LEUVEN   (Belgium)

ⁱ ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^j Institut Cochin   (France)

^k CHARLES UNIVERSITY   (Czech Republic)

more..

Author keywords

Diagnosis; Extremely low gestational age; Hypotension; Newborn; Survey; Treatment

Indexed keywords

DOPAMINE; PLACEBO; SODIUM CHLORIDE; VASOCONSTRICTOR AGENT;

ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; EXTREMELY LOW BIRTH WEIGHT; FEMALE; GESTATIONAL AGE; HUMAN; HYPOTENSION; INFANT; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEWBORN; NEWBORN CARE; NEWBORN MORTALITY; ORGAN PERFUSION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ARTERIAL PRESSURE; BRAIN INJURIES; CHILD DEVELOPMENT; CLINICAL PROTOCOL; CLINICAL TRIAL; DRUG EFFECTS; EUROPE; FLUID THERAPY; METHODOLOGY; MULTIMODALITY CANCER THERAPY; PATHOPHYSIOLOGY; PREMATURITY; PRESCHOOL CHILD; TIME; TREATMENT OUTCOME; EXTREMELY LOW GESTATIONAL AGE; MEAN ARTERIAL PRESSURE; PATIENT SELECTION; RESEARCH ETHICS; SMALL FOR DATE INFANT; STUDY DESIGN; SURVIVAL;

ARTERIAL PRESSURE; BRAIN INJURIES; CHILD DEVELOPMENT; CHILD, PRESCHOOL; CLINICAL PROTOCOLS; COMBINED MODALITY THERAPY; DOPAMINE; EUROPE; FLUID THERAPY; GESTATIONAL AGE; HUMANS; HYPOTENSION; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 84895700662     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000357553     Document Type: Article

References (48)

1. Dempsey EM, Barrington KJ: Diagnostic criteria and therapeutic interventions for the hypotensive very low birth weight infant. J Perinatol 2006; 26: 677-681.
2. Laughon M, et al: Factors associated with treatment for hypotension in extremely low gestational age newborns during the first postnatal week. Pediatrics 2007; 119: 273-280.
3. Dempsey EM, Barrington KJ: Treating hypotension in the preterm infant: when and with what: a critical and systematic review. J Perinatol 2007; 27: 469-478.
4. Osborn DA, Evans N: Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database Syst Rev 2004; 2:CD002055.
5. Subhedar NV, Shaw NJ: Dopamine versus dobutamine for hypotensive preterm infants. Cochrane Database Syst Rev 2003; 3:CD001242.
6. Ibrahim H, Sinha IP, Subhedar NV: Corticosteroids for treating hypotension in preterm infants. Cochrane Database Syst Rev 2011; 12:CD003662.
7. Kluckow M, Evans N: Relationship between blood pressure and cardiac output in preterm infants requiring mechanical ventilation. J Pediatr 1996; 129: 506-512.
8. Pladys P, et al: Left ventricle output and mean arterial blood pressure in preterm infants during the 1st day of life. Eur J Pediatr 1999; 158: 817-824.
9. Groves AM, et al: Relationship between blood pressure and blood flow in newborn preterm infants. Arch Dis Child Fetal Neonatal Ed 2008; 93:F29-F32.
10. Victor S, et al: The relationship between cardiac output, cerebral electrical activity, cerebral fractional oxygen extraction and peripheral blood flow in premature newborn infants. Pediatr Res 2006; 60: 456-460.
11. Dempsey EM, Al Hazzani F, Barrington KJ: Permissive hypotension in the extremely low birthweight infant with signs of good perfusion. Arch Dis Child Fetal Neonatal Ed 2009; 94:F241-F244.
12. Synnes AR, et al: Variations in intraventricular hemorrhage incidence rates among Canadian neonatal intensive care units. J Pediatr 2001; 138: 525-531.
13. Goldberg RN, et al: The association of rapid volume expansion and intraventricular hemorrhage in the preterm infant. J Pediatr 1980; 96: 1060-1063.
14. Filippi L, et al: Dopamine versus dobutamine in very low birthweight infants: endocrine effects. Arch Dis Child Fetal Neonatal Ed 2007; 92:F367-F371.
15. Zhang J, et al: Mechanisms of blood pressure increase induced by dopamine in hypotensive preterm neonates. Arch Dis Child Fetal Neonatal Ed 1999; 81:F99-F104.
16. Osborn D, Evans N, Kluckow M: Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. J Pediatr 2002; 140: 183-191.
17. Lee J, Rajadurai VS, Tan KW: Blood pressure standards for very low birthweight infants during the first day of life. Arch Dis Child Fetal Neonatal Ed 1999; 81:F168-F170.
18. Spinazzola RM, Harper RG: Blood pressure values in 500-to 750-gram birthweight infants in the first week of life. J Perinatol 1991; 11: 147.
19. Watkins AM, West CR, Cooke RW: Blood pressure and cerebral haemorrhage and ischaemia in very low birthweight infants. Early Hum Dev 1989; 19: 103.
20. Versmold HT, et al: Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4,220 grams. Pediatrics 1981; 67: 607-613.
21. Hegyi T, et al: Blood pressure ranges in premature infants. I. The first hours of life. J Pediatr 1994; 124: 627-633.
22. Hegyi T, et al: Blood pressure ranges in premature infants: II. The first week of life. Pediatrics 1996; 97: 336-342.
23. Bada H, et al: Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage. J Pediatr 1990; 117: 607-614.
24. Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit of the Royal College of Physicians. Arch Dis Child 1992; 67: 1221-1227.
25. Pellicer A, et al: Cardiovascular support for low birth weight infants and cerebral hemodynamics: a randomized, blinded, clinical trial. Pediatrics 2005; 115: 1501-1512.
26. Cunningham S, et al: Intra-arterial blood pressure reference ranges, death and morbidity in very low birthweight infants during the first seven days of life. Early Hum Dev 1999; 56: 151-165.
27. Barrington K, Lee S, Stewart S: Differing blood pressure thresholds in preterm infants, effects on frequency of diagnosis of hypotension and intraventricular hemorrhage. PAS Meeting Abstracts 2002; 2648.
28. Miall-Allen VM, De Vries LS, Whitelaw AL: Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child 1987; 62: 1068-1069.
29. Martens SE, et al: Is hypotension a major risk factor for neurological morbidity at term age in very preterm infants Early Hum Dev 2003; 75: 79-89.
30. Murphy D, et al: Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies. Lancet 1995; 346: 1449-1454.
31. OShea T, et al: Survival and developmental disability in infants with birth weights of 501 to 800 grams, born between 1979 and 1994. Pediatrics 1997; 100: 982-986.
32. Raju NV, et al: Capillary refill time in the hands and feet of normal newborn infants. Clin Pediatr (Phila) 1999; 38: 139-144.
33. Wodey E, et al: Capillary refilling time and hemodynamics in neonates: a Doppler echocardiographic evaluation. Crit Care Med 1998; 26: 1437-1440.
34. Osborn DA, Evans N, Kluckow M: Clinical detection of low upper body blood flow in very premature infants using blood pressure, capillary refill time, and central-peripheral temperature difference. Arch Dis Child Fetal Neonatal Ed 2004; 89:F168-F173.
35. Miletin J, Pichova K, Dempsey E: Bedside detection of low systemic flow in the very low birth weight infant on day 1 of life. Eur J Pediatr 2009; 168: 809-813.
36. Fitzgerald MJ, Goto M: Early metabolic effects of sepsis in the preterm infant: lactic acidosis and increased glucose requirement. J Pediatr 1992; 121: 951.
37. Abubacker M, Yoxall CW, Lamont G: Perioperative blood lactate concentrations in preterm babies with necrotising enterocolitis. Eur J Pediatr Surg 2003; 13: 35-39.
38. Groenendaal F, et al: Early arterial lactate and prediction of outcome in preterm neonates admitted to a neonatal intensive care unit. Biol Neonate 2003; 83: 171-176.
39. Deshpande SA, Platt MP: Association between blood lactate and acid-base status and mortality in ventilated babies. Arch Dis Child Fetal Neonatal Ed 1997; 76:F15-F20.
40. Nadeem M, Clarke A, Dempsey E: Day 1 serum lactate values in preterm infants less than 32 weeks gestation. Eur J Pediatr 2010; 169: 667-670.
41. Wardle SP, Yoxall CW, Weindling AM: Peripheral oxygenation in hypotensive preterm babies. Pediatr Res 1999; 45: 343-349.
42. Miletin J, Dempsey EM: Low superior vena cava flow on day 1 and adverse outcome in the very low birthweight infant. Arch Dis Child Fetal Neonatal Ed 2008; 93:F368-F371.
43. Evans N, Iyer P: Incompetence of the foramen ovale in preterm infants supported by mechanical ventilation. J Pediatr 1994; 125: 786-792.
44. Evans N, Iyer P: Assessment of ductus arteriosus shunt in preterm infants supported by mechanical ventilation: effect of interatrial shunting. J Pediatr 1994; 125: 778-785.
45. Naulaers G, et al: Cerebral tissue oxygenation index in very premature infants. Arch Dis Child Fetal Neonatal Ed 2002; 87:F189-F192.
46. Nicklin SE, et al: The light still shines, but not that brightly The current status of perinatal near infrared spectroscopy. Arch Dis Child Fetal Neonatal Ed 2003; 88:F263.
47. West CR, et al: Early low cardiac output is associated with compromised electroencephalographic activity in very preterm infants. Pediatr Res 2006; 59: 610-615.
48. Dempsey EM, Connolly K: Who are the PDCO Eur J Pediatr 2013, Epub ahead of print.